FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207660520> ?p ?o ?g. }

• W3207660520 endingPage "e1009506" @default.
• W3207660520 startingPage "e1009506" @default.
• W3207660520 abstract "Mechanical forces, actin filament turnover, and adhesion to the extracellular environment regulate lamellipodial protrusions. Computational and mathematical models at the continuum level have been used to investigate the molecular clutch mechanism, calculating the stress profile through the lamellipodium and around focal adhesions. However, the forces and deformations of individual actin filaments have not been considered while interactions between actin networks and actin bundles is not easily accounted with such methods. We develop a filament-level model of a lamellipodial actin network undergoing retrograde flow using 3D Brownian dynamics. Retrograde flow is promoted in simulations by pushing forces from the leading edge (due to actin polymerization), pulling forces (due to molecular motors), and opposed by viscous drag in cytoplasm and focal adhesions. Simulated networks have densities similar to measurements in prior electron micrographs. Connectivity between individual actin segments is maintained by permanent and dynamic crosslinkers. Remodeling of the network occurs via the addition of single actin filaments near the leading edge and via filament bond severing. We investigated how several parameters affect the stress distribution, network deformation and retrograde flow speed. The model captures the decrease in retrograde flow upon increase of focal adhesion strength. The stress profile changes from compression to extension across the leading edge, with regions of filament bending around focal adhesions. The model reproduces the observed reduction in retrograde flow speed upon exposure to cytochalasin D, which halts actin polymerization. Changes in crosslinker concentration and dynamics, as well as in the orientation pattern of newly added filaments demonstrate the model's ability to generate bundles of filaments perpendicular (actin arcs) or parallel (microspikes) to the protruding direction." @default.
• W3207660520 created "2021-10-25" @default.
• W3207660520 creator A5036890832 @default.
• W3207660520 creator A5040430789 @default.
• W3207660520 date "2021-10-18" @default.
• W3207660520 modified "2023-09-27" @default.
• W3207660520 title "Discrete mechanical model of lamellipodial actin network implements molecular clutch mechanism and generates arcs and microspikes" @default.
• W3207660520 cites W1582586987 @default.
• W3207660520 cites W1963969404 @default.
• W3207660520 cites W1965277326 @default.
• W3207660520 cites W1967825045 @default.
• W3207660520 cites W1969011037 @default.
• W3207660520 cites W1969367867 @default.
• W3207660520 cites W1974086731 @default.
• W3207660520 cites W1974329525 @default.
• W3207660520 cites W1979544767 @default.
• W3207660520 cites W1980256109 @default.
• W3207660520 cites W1992045321 @default.
• W3207660520 cites W1993016783 @default.
• W3207660520 cites W1996680631 @default.
• W3207660520 cites W2000275460 @default.
• W3207660520 cites W2003238160 @default.
• W3207660520 cites W2005972339 @default.
• W3207660520 cites W2011412709 @default.
• W3207660520 cites W2019559746 @default.
• W3207660520 cites W2029459791 @default.
• W3207660520 cites W2029695466 @default.
• W3207660520 cites W2031952383 @default.
• W3207660520 cites W2033881548 @default.
• W3207660520 cites W2038760621 @default.
• W3207660520 cites W2038870603 @default.
• W3207660520 cites W2040169304 @default.
• W3207660520 cites W2041040218 @default.
• W3207660520 cites W2041772318 @default.
• W3207660520 cites W2050612706 @default.
• W3207660520 cites W2055601386 @default.
• W3207660520 cites W2070967303 @default.
• W3207660520 cites W2071102178 @default.
• W3207660520 cites W2074832680 @default.
• W3207660520 cites W2075738656 @default.
• W3207660520 cites W2083215599 @default.
• W3207660520 cites W2088479380 @default.
• W3207660520 cites W2089510772 @default.
• W3207660520 cites W2098495568 @default.
• W3207660520 cites W2098642556 @default.
• W3207660520 cites W2101191478 @default.
• W3207660520 cites W2105402224 @default.
• W3207660520 cites W2105789974 @default.
• W3207660520 cites W2108731616 @default.
• W3207660520 cites W2113300874 @default.
• W3207660520 cites W2115378800 @default.
• W3207660520 cites W2117395405 @default.
• W3207660520 cites W2119793335 @default.
• W3207660520 cites W2123735680 @default.
• W3207660520 cites W2125221503 @default.
• W3207660520 cites W2125644189 @default.
• W3207660520 cites W2125841358 @default.
• W3207660520 cites W2126496496 @default.
• W3207660520 cites W2131832714 @default.
• W3207660520 cites W2135977869 @default.
• W3207660520 cites W2145123926 @default.
• W3207660520 cites W2146667247 @default.
• W3207660520 cites W2146894615 @default.
• W3207660520 cites W2148454908 @default.
• W3207660520 cites W2149216170 @default.
• W3207660520 cites W2149374899 @default.
• W3207660520 cites W2151407115 @default.
• W3207660520 cites W2153626442 @default.
• W3207660520 cites W2154568995 @default.
• W3207660520 cites W2155418451 @default.
• W3207660520 cites W2164244652 @default.
• W3207660520 cites W2166601921 @default.
• W3207660520 cites W2166927847 @default.
• W3207660520 cites W2167146326 @default.
• W3207660520 cites W2168586729 @default.
• W3207660520 cites W2172269720 @default.
• W3207660520 cites W2203323190 @default.
• W3207660520 cites W2211191608 @default.
• W3207660520 cites W2233203177 @default.
• W3207660520 cites W2331811377 @default.
• W3207660520 cites W2513957680 @default.
• W3207660520 cites W2521600174 @default.
• W3207660520 cites W2581379811 @default.
• W3207660520 cites W2592965097 @default.
• W3207660520 cites W2728122910 @default.
• W3207660520 cites W2752133552 @default.
• W3207660520 cites W2804525950 @default.
• W3207660520 cites W2886383051 @default.
• W3207660520 cites W2894924203 @default.
• W3207660520 cites W2900927902 @default.
• W3207660520 cites W2952730233 @default.
• W3207660520 cites W2962965174 @default.
• W3207660520 cites W2973091351 @default.
• W3207660520 cites W2974148042 @default.
• W3207660520 cites W2985428808 @default.
• W3207660520 cites W2991064661 @default.
• W3207660520 cites W3022104547 @default.
• W3207660520 cites W3028048360 @default.

• next