Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207664652> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3207664652 endingPage "7411" @default.
- W3207664652 startingPage "7402" @default.
- W3207664652 abstract "Interleukin (IL)-22 is a multifunctional cytokine with a very short half-life that activates STAT3 and can elicit strong anti-inflammatory effects in the intestine but can induce inflammation in other sites. Several long-circulating IL-22 fusion proteins have been manufactured to date; however, those were associated with adverse effects in other organs limiting their utility for treating intestinal inflammation. Targeted delivery of IL-22 to the intestine could utilize its anti-inflammatory properties and overcome systemic toxicity. Therefore, this study aimed to synthesise large pore mesoporous silica nanoparticles (LPMSN), load recombinant (r)IL-22 in the LPMSN and test its bioactivity in the STAT3 reporter LS174T, wild type LS174T, Caco-2 intestinal epithelial cells, and healthy human colonic organoids. Our data showed one hundred percent loading capacity (w/w) of the synthesised LPMSN, which prolonged IL-22 induced STAT3 luciferase activities in LS174T and p-STAT3 immunofluorescence in Caco-2 cells. LPMSN also stabilized and increased the permeability of rIL-22 across Caco-2 monolayers. Moreover, LPMSN-IL-22 retained the functionality of the cytokine in human colonic organoids. Taken together, these data demonstrate the protection and effective delivery of IL-22 using bio-nanomaterials (LPMSN) that could enable targeted oral delivery of this IL-22." @default.
- W3207664652 created "2021-10-25" @default.
- W3207664652 creator A5024363330 @default.
- W3207664652 creator A5027627095 @default.
- W3207664652 creator A5055486123 @default.
- W3207664652 creator A5062042129 @default.
- W3207664652 creator A5064165690 @default.
- W3207664652 creator A5084287784 @default.
- W3207664652 creator A5087737801 @default.
- W3207664652 date "2021-01-01" @default.
- W3207664652 modified "2023-10-03" @default.
- W3207664652 title "Facile synthesis of dendrimer like mesoporous silica nanoparticles to enhance targeted delivery of interleukin-22" @default.
- W3207664652 cites W1990255257 @default.
- W3207664652 cites W2002513358 @default.
- W3207664652 cites W2006347066 @default.
- W3207664652 cites W2006522099 @default.
- W3207664652 cites W2052891178 @default.
- W3207664652 cites W2070517548 @default.
- W3207664652 cites W2097649221 @default.
- W3207664652 cites W2108969731 @default.
- W3207664652 cites W2195777839 @default.
- W3207664652 cites W2517112160 @default.
- W3207664652 cites W2606079573 @default.
- W3207664652 cites W2795245284 @default.
- W3207664652 cites W2892663691 @default.
- W3207664652 cites W2912761389 @default.
- W3207664652 cites W2947979837 @default.
- W3207664652 cites W2949925359 @default.
- W3207664652 cites W2962647820 @default.
- W3207664652 cites W2967396404 @default.
- W3207664652 cites W2987932370 @default.
- W3207664652 cites W3042912767 @default.
- W3207664652 cites W3088888969 @default.
- W3207664652 cites W3093471577 @default.
- W3207664652 cites W3138947892 @default.
- W3207664652 cites W3168135255 @default.
- W3207664652 cites W3178278881 @default.
- W3207664652 cites W4230633180 @default.
- W3207664652 doi "https://doi.org/10.1039/d1bm01352a" @default.
- W3207664652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34709241" @default.
- W3207664652 hasPublicationYear "2021" @default.
- W3207664652 type Work @default.
- W3207664652 sameAs 3207664652 @default.
- W3207664652 citedByCount "4" @default.
- W3207664652 countsByYear W32076646522022 @default.
- W3207664652 countsByYear W32076646522023 @default.
- W3207664652 crossrefType "journal-article" @default.
- W3207664652 hasAuthorship W3207664652A5024363330 @default.
- W3207664652 hasAuthorship W3207664652A5027627095 @default.
- W3207664652 hasAuthorship W3207664652A5055486123 @default.
- W3207664652 hasAuthorship W3207664652A5062042129 @default.
- W3207664652 hasAuthorship W3207664652A5064165690 @default.
- W3207664652 hasAuthorship W3207664652A5084287784 @default.
- W3207664652 hasAuthorship W3207664652A5087737801 @default.
- W3207664652 hasConcept C185592680 @default.
- W3207664652 hasConcept C203014093 @default.
- W3207664652 hasConcept C2776914184 @default.
- W3207664652 hasConcept C2778690821 @default.
- W3207664652 hasConcept C71924100 @default.
- W3207664652 hasConcept C86803240 @default.
- W3207664652 hasConcept C95444343 @default.
- W3207664652 hasConceptScore W3207664652C185592680 @default.
- W3207664652 hasConceptScore W3207664652C203014093 @default.
- W3207664652 hasConceptScore W3207664652C2776914184 @default.
- W3207664652 hasConceptScore W3207664652C2778690821 @default.
- W3207664652 hasConceptScore W3207664652C71924100 @default.
- W3207664652 hasConceptScore W3207664652C86803240 @default.
- W3207664652 hasConceptScore W3207664652C95444343 @default.
- W3207664652 hasFunder F4320320984 @default.
- W3207664652 hasFunder F4320321723 @default.
- W3207664652 hasFunder F4320334705 @default.
- W3207664652 hasIssue "22" @default.
- W3207664652 hasLocation W32076646521 @default.
- W3207664652 hasLocation W32076646522 @default.
- W3207664652 hasOpenAccess W3207664652 @default.
- W3207664652 hasPrimaryLocation W32076646521 @default.
- W3207664652 hasRelatedWork W1969059469 @default.
- W3207664652 hasRelatedWork W1985185203 @default.
- W3207664652 hasRelatedWork W1997079849 @default.
- W3207664652 hasRelatedWork W2021444609 @default.
- W3207664652 hasRelatedWork W2039513919 @default.
- W3207664652 hasRelatedWork W2072701076 @default.
- W3207664652 hasRelatedWork W2305240766 @default.
- W3207664652 hasRelatedWork W2531441777 @default.
- W3207664652 hasRelatedWork W2914855167 @default.
- W3207664652 hasRelatedWork W4210541988 @default.
- W3207664652 hasVolume "9" @default.
- W3207664652 isParatext "false" @default.
- W3207664652 isRetracted "false" @default.
- W3207664652 magId "3207664652" @default.
- W3207664652 workType "article" @default.