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• W3207675861 abstract "Despite increasing evidence for an association between circulating uric acid (UA) and depression, the directionality of this association remains unclear and is potentially moderated by low-grade inflammation. Thus, the present study aimed to investigate the cross-sectional association between serum UA concentration and depressive symptoms in Korean individuals with and without low-grade inflammation, as measured using serum high-specific C-reactive protein (hs-CRP) levels. The final study sample comprised 4188 participants, aged 19-79 years, from the Korea National Health and Nutrition Examination Study 2016. Data on serum uric acid (UA) concentrations, serum hs-CRP levels, Patient Health Questionnaire-9 (PHQ-9) scores, and relative covariates were retrieved. Negative binomial regression with adjustment for the complex sample design was used to analyze the associations. After adjusting for covariates, log-transformed serum UA concentrations and total PHQ-9 scores were positively associated (incidence rate ratio [IRR] = 1.34 [95% confidence interval [CI] = 1.09-1.66]) for participants without low-grade inflammation and inversely associated (IRR = 0.64 [95% CI = 0.45-0.92]) for participants with low-grade inflammation. In conclusion, the direction of the association between serum UA and depressive symptoms was the opposite in participants with and without low-grade inflammation. The study has the limitation of potential uncontrolled confounders." @default.
• W3207675861 created "2021-10-25" @default.
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• W3207675861 date "2021-10-14" @default.
• W3207675861 modified "2023-10-13" @default.
• W3207675861 title "Association between serum uric acid and depressive symptoms stratified by low-grade inflammation status" @default.
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• W3207675861 doi "https://doi.org/10.1038/s41598-021-99312-x" @default.
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