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• W3207680614 abstract "Abstract Directed collective cell migration (dCCM) is essential for morphogenesis 1, 2 . Cell clusters migrate in inherently complex in vivo environments composed of chemical, electrical, mechanical as well as topological features. While these environmental factors have been shown to allow dCCM in vitro , our understanding of dCCM in vivo is mostly limited to chemical guidance 3 . Thus, despite its wide biological relevance, the mechanisms that guide dCCM in vivo remain unclear. To address this, we study endogenous electric fields in relation to the migratory environment of the Xenopus laevis cephalic neural crest, an embryonic cell population that collectively and directionally migrates in vivo 4 , and whose migratory mode has been linked to cancer invasion and metastasis 5 . Combining bioelectrical, biomechanical and molecular tools, we show that endogenous electric fields drive neural crest dCCM via electrotaxis in vivo . Moreover, we identify the voltage-sensitive phosphatase 1 (Vsp1) as a key component of the molecular mechanism used by neural crest cells to transduce electric fields into a directional cue in vivo . Furthermore, Vsp1 function is specifically required for electrotaxis, being dispensable for cell motility and chemotaxis. Finally, we reveal that endogenous electric fields are mechanoelectrically established. Mechanistically, convergent extension movements of the neural fold generate membrane tension, which in turn opens stretch-activated channels to mobilise the ions required to fuel electric fields. Overall, our results reveal a mechanism of cell guidance, where electrotaxis emerges from the mechanoelectrical and molecular interplay between neighbouring tissues. More broadly, our data contribute to validate the, otherwise understudied, functions of endogenous bioelectrical stimuli in morphogenetic processes 6 ." @default.
• W3207680614 created "2021-10-25" @default.
• W3207680614 creator A5031978763 @default.
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• W3207680614 date "2021-10-12" @default.
• W3207680614 modified "2023-10-11" @default.
• W3207680614 title "Stretch-induced endogenous electric fields drive neural crest directed collective cell migration <i>in vivo</i>" @default.
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• W3207680614 doi "https://doi.org/10.1101/2021.10.11.463916" @default.
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