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• W3207702167 endingPage "577745" @default.
• W3207702167 startingPage "577745" @default.
• W3207702167 abstract "The symptoms of Fragile X syndrome (FXS) are driven in part by abnormal glial-mediated function. FXS astrocytes release elevated levels of immune-related factors interleukin-6 (IL-6) and tenascin C (TNC), and also demonstrate increased purinergic signaling, a pathway linked to signaling factor release. Here, in cortical astrocytes from the Fmr1 knockout (KO) FXS mouse model, purinergic agonism enhanced TNC secretion and STAT3 phosphorylation, two processes linked to elevated IL-6 secretion in FXS, while STAT3 knockdown and TLR4 antagonism normalized Fmr1 KO IL-6 release. We therefore suggest that purinergic signaling and immune regulatory pathways converge to drive FXS cortical pro-inflammatory responses." @default.
• W3207702167 created "2021-10-25" @default.
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• W3207702167 date "2021-12-01" @default.
• W3207702167 modified "2023-09-30" @default.
• W3207702167 title "Converging purinergic and immune signaling pathways drive IL-6 secretion by Fragile X cortical astrocytes via STAT3" @default.
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• W3207702167 doi "https://doi.org/10.1016/j.jneuroim.2021.577745" @default.
• W3207702167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34695768" @default.
• W3207702167 hasPublicationYear "2021" @default.
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