FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207718759> ?p ?o ?g. }

• W3207718759 endingPage "2998" @default.
• W3207718759 startingPage "2987" @default.
• W3207718759 abstract "The ESKAPE pathogens comprise a group of multidrug-resistant bacteria that are the leading cause of nosocomial infections worldwide. The prevalence of antibiotic resistant strains and the relative ease by which bacteria acquire resistance genes highlight the continual need for the development of novel antibiotics against new drug targets. The methylerythritol phosphate (MEP) pathway is an attractive target for the development of new antibiotics. The MEP pathway governs the synthesis of isoprenoids, which are key lipid precursors for vital cell components such as ubiquinone and bacterial hopanoids. Additionally, the MEP pathway is entirely distinct from the corresponding mammalian pathway, the mevalonic acid (MVA) pathway, making the first committed enzyme of the MEP pathway, 1-deoxy-d-xylulose 5-phosphate reductoisomerase (IspC), an attractive target for antibiotic development. To facilitate drug development against two of the ESKAPE pathogens, Acinetobacter baumannii and Klebsiella pneumoniae, we cloned, expressed, purified, and characterized IspC from these two Gram-negative bacteria. Enzyme inhibition assays using IspC from these two pathogens, and compounds fosmidomycin and FR900098, indicate IC50 values ranging from 19.5-45.5 nM. Antimicrobial susceptibility tests with these inhibitors reveal that A. baumannii is susceptible to FR900098, whereas K. pneumoniae is susceptible to both compounds. Finally, to facilitate structure-based drug design of inhibitors targeting A. baumannii IspC, we determined the 2.5 Å crystal structure of IspC from A. baumannii in complex with inhibitor FR900098, and cofactors NADPH and magnesium." @default.
• W3207718759 created "2021-10-25" @default.
• W3207718759 creator A5003120669 @default.
• W3207718759 creator A5004937787 @default.
• W3207718759 creator A5034475804 @default.
• W3207718759 creator A5054057007 @default.
• W3207718759 creator A5072895540 @default.
• W3207718759 creator A5090709441 @default.
• W3207718759 date "2021-10-21" @default.
• W3207718759 modified "2023-10-10" @default.
• W3207718759 title "Characterization and Inhibition of 1-Deoxy-<scp>d</scp>-Xylulose 5-Phosphate Reductoisomerase: A Promising Drug Target in <i>Acinetobacter baumannii</i> and <i>Klebsiella pneumoniae</i>" @default.
• W3207718759 cites W1539678687 @default.
• W3207718759 cites W1597959609 @default.
• W3207718759 cites W1656423917 @default.
• W3207718759 cites W1936440524 @default.
• W3207718759 cites W1965528325 @default.
• W3207718759 cites W1969325303 @default.
• W3207718759 cites W1971521079 @default.
• W3207718759 cites W1974833847 @default.
• W3207718759 cites W1977444198 @default.
• W3207718759 cites W1979973356 @default.
• W3207718759 cites W1986021215 @default.
• W3207718759 cites W1989226466 @default.
• W3207718759 cites W1998555588 @default.
• W3207718759 cites W2002921064 @default.
• W3207718759 cites W2003219159 @default.
• W3207718759 cites W2005942671 @default.
• W3207718759 cites W2008872195 @default.
• W3207718759 cites W2013883719 @default.
• W3207718759 cites W2014612798 @default.
• W3207718759 cites W2018586020 @default.
• W3207718759 cites W2020576710 @default.
• W3207718759 cites W2021997864 @default.
• W3207718759 cites W2023372492 @default.
• W3207718759 cites W2024568013 @default.
• W3207718759 cites W2028487827 @default.
• W3207718759 cites W2028539126 @default.
• W3207718759 cites W2038914330 @default.
• W3207718759 cites W2041792339 @default.
• W3207718759 cites W2042353065 @default.
• W3207718759 cites W2045718514 @default.
• W3207718759 cites W2047127147 @default.
• W3207718759 cites W2050085208 @default.
• W3207718759 cites W2053635523 @default.
• W3207718759 cites W2057720363 @default.
• W3207718759 cites W2068066782 @default.
• W3207718759 cites W2069030760 @default.
• W3207718759 cites W2070626264 @default.
• W3207718759 cites W2073872717 @default.
• W3207718759 cites W2077648184 @default.
• W3207718759 cites W2079989275 @default.
• W3207718759 cites W2080172904 @default.
• W3207718759 cites W2080616046 @default.
• W3207718759 cites W2080885576 @default.
• W3207718759 cites W2081290361 @default.
• W3207718759 cites W2101707609 @default.
• W3207718759 cites W2101843494 @default.
• W3207718759 cites W2102749349 @default.
• W3207718759 cites W2104403339 @default.
• W3207718759 cites W2105496367 @default.
• W3207718759 cites W2114276495 @default.
• W3207718759 cites W2117508830 @default.
• W3207718759 cites W2118244185 @default.
• W3207718759 cites W2126109293 @default.
• W3207718759 cites W2127157268 @default.
• W3207718759 cites W2131318944 @default.
• W3207718759 cites W2136554135 @default.
• W3207718759 cites W2142251083 @default.
• W3207718759 cites W2142801964 @default.
• W3207718759 cites W2143243315 @default.
• W3207718759 cites W2145018290 @default.
• W3207718759 cites W2149092807 @default.
• W3207718759 cites W2152274865 @default.
• W3207718759 cites W2155451022 @default.
• W3207718759 cites W2164267446 @default.
• W3207718759 cites W2347102183 @default.
• W3207718759 cites W2514306027 @default.
• W3207718759 cites W2527370312 @default.
• W3207718759 cites W2574997685 @default.
• W3207718759 cites W2579748466 @default.
• W3207718759 cites W2588060216 @default.
• W3207718759 cites W2742734343 @default.
• W3207718759 cites W2793582850 @default.
• W3207718759 cites W2945197482 @default.
• W3207718759 cites W4211056710 @default.
• W3207718759 cites W4243433041 @default.
• W3207718759 doi "https://doi.org/10.1021/acsinfecdis.1c00132" @default.
• W3207718759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34672535" @default.
• W3207718759 hasPublicationYear "2021" @default.
• W3207718759 type Work @default.
• W3207718759 sameAs 3207718759 @default.
• W3207718759 citedByCount "6" @default.
• W3207718759 countsByYear W32077187592022 @default.
• W3207718759 countsByYear W32077187592023 @default.
• W3207718759 crossrefType "journal-article" @default.
• W3207718759 hasAuthorship W3207718759A5003120669 @default.
• W3207718759 hasAuthorship W3207718759A5004937787 @default.
• W3207718759 hasAuthorship W3207718759A5034475804 @default.

• next