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- W3207758248 abstract "Toxoplasma gondii (T. gondii) is a neurotropic protozoan parasite, which can cause mental and behavioural disorders. The present study aimed to elucidate the effects and underlying molecular mechanisms of sertraline (SERT) on T. gondii-induced depression-like behaviours. In the present study, a mouse model and a microglial cell line (BV2 cells) model were established by infecting with the T. gondii RH strain. In in vivo and in vitro experiments, the underlying molecular mechanisms of SERT in inhibiting depression-like behaviours and cellular perturbations caused by T. gondii infection were investigated in the mouse brain and BV2 cells. The administration of SERT significantly ameliorated depression-like behaviours in T. gondii-infected mice. Furthermore, SERT inhibited T. gondii proliferation. Treatment with SERT significantly inhibited the activation of microglia and decreased levels of pro-inflammatory cytokines such as tumour necrosis factor-alpha, and interferon-gamma, by down-regulating tumour necrosis factor receptor 1/nuclear factor-kappa B signalling pathway, thereby ameliorating the depression-like behaviours induced by T. gondii infection. Our study provides insight into the underlying molecular mechanisms of the newly discovered role of SERT against T. gondii-induced depression-like behaviours." @default.
- W3207758248 created "2021-10-25" @default.
- W3207758248 creator A5018516855 @default.
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- W3207758248 date "2021-10-20" @default.
- W3207758248 modified "2023-10-10" @default.
- W3207758248 title "New role of sertraline against <i>Toxoplasma gondii</i> ‐induced depression‐like behaviours in mice" @default.
- W3207758248 cites W1608181714 @default.
- W3207758248 cites W1898709646 @default.
- W3207758248 cites W1923774236 @default.
- W3207758248 cites W1965931837 @default.
- W3207758248 cites W1965942744 @default.
- W3207758248 cites W1968151012 @default.
- W3207758248 cites W1971132520 @default.
- W3207758248 cites W1973929801 @default.
- W3207758248 cites W1979258795 @default.
- W3207758248 cites W1990023697 @default.
- W3207758248 cites W1991462471 @default.
- W3207758248 cites W1995834364 @default.
- W3207758248 cites W1996454121 @default.
- W3207758248 cites W1997106678 @default.
- W3207758248 cites W2002250647 @default.
- W3207758248 cites W2026679068 @default.
- W3207758248 cites W2027435977 @default.
- W3207758248 cites W2027831037 @default.
- W3207758248 cites W2029791128 @default.
- W3207758248 cites W2033811826 @default.
- W3207758248 cites W2043310364 @default.
- W3207758248 cites W2058892414 @default.
- W3207758248 cites W2060042009 @default.
- W3207758248 cites W2067888376 @default.
- W3207758248 cites W2071642365 @default.
- W3207758248 cites W2071857583 @default.
- W3207758248 cites W2078660110 @default.
- W3207758248 cites W2082870547 @default.
- W3207758248 cites W2090409700 @default.
- W3207758248 cites W2098038342 @default.
- W3207758248 cites W2108163416 @default.
- W3207758248 cites W2110804164 @default.
- W3207758248 cites W2114231431 @default.
- W3207758248 cites W2123087183 @default.
- W3207758248 cites W2131685014 @default.
- W3207758248 cites W2131964197 @default.
- W3207758248 cites W2148898943 @default.
- W3207758248 cites W2152916509 @default.
- W3207758248 cites W2165969041 @default.
- W3207758248 cites W2171194568 @default.
- W3207758248 cites W2237598232 @default.
- W3207758248 cites W2259912978 @default.
- W3207758248 cites W2292571541 @default.
- W3207758248 cites W2294480362 @default.
- W3207758248 cites W2313048608 @default.
- W3207758248 cites W2317869077 @default.
- W3207758248 cites W2394581761 @default.
- W3207758248 cites W2442069060 @default.
- W3207758248 cites W2479000041 @default.
- W3207758248 cites W2491168016 @default.
- W3207758248 cites W2512654662 @default.
- W3207758248 cites W2574448106 @default.
- W3207758248 cites W2578653340 @default.
- W3207758248 cites W2582458998 @default.
- W3207758248 cites W2679057414 @default.
- W3207758248 cites W2737153363 @default.
- W3207758248 cites W2765867172 @default.
- W3207758248 cites W2766031876 @default.
- W3207758248 cites W2772765913 @default.
- W3207758248 cites W2773793497 @default.
- W3207758248 cites W2792369931 @default.
- W3207758248 cites W2793019350 @default.
- W3207758248 cites W2887924810 @default.
- W3207758248 cites W2889889361 @default.
- W3207758248 cites W2892544599 @default.
- W3207758248 cites W2893590951 @default.
- W3207758248 cites W2902518856 @default.
- W3207758248 cites W2904378965 @default.
- W3207758248 cites W2904593198 @default.
- W3207758248 cites W2912211276 @default.
- W3207758248 cites W2923280409 @default.
- W3207758248 cites W2949224014 @default.
- W3207758248 cites W2952691519 @default.
- W3207758248 cites W2953171892 @default.
- W3207758248 cites W2964096097 @default.
- W3207758248 cites W3008324615 @default.
- W3207758248 cites W3022434530 @default.
- W3207758248 cites W3039666756 @default.
- W3207758248 cites W3083948029 @default.
- W3207758248 cites W3104725836 @default.
- W3207758248 cites W3108168291 @default.
- W3207758248 cites W3159737027 @default.
- W3207758248 cites W3200229730 @default.
- W3207758248 cites W4211218717 @default.
- W3207758248 cites W4231698307 @default.