Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207777372> ?p ?o ?g. }
- W3207777372 abstract "Introduction: Transient receptor potential ankyrin-1 positive (TRPA1+ve) nociceptors, primarily present as peptidergic neuronal afferents in the colon are sensors of disturbance in lower gastrointestinal tract including pain induced by different pathologies. Their therapeutic role in the alleviation of chronic pain (receptor antagonism and receptor desensitization) associated with inflammatory bowel diseases (IBD) is reported. However, there is limited literature available about their role in formation and sustenance of the mucosal layer, and its interaction with host physiology as well as luminal microbial community. The aim of this study focuses on the effects of nociceptive TRPA1 channel desensitization on colonic mucus production and gut health. Methods: TRPA1+ve nociceptors were desensitized by rectal administration of capsazepine. Ileum, colon was harvested and cecum content was collected. We performed morphological/histological analysis, gut permeability alteration, gene expression changes, colon metabolite profiling, and gut microbial abundance in these animals. Results: We found that presence of TRPA1-positive nociceptors is required for mucus layer integrity, using an intra-rectal capsazepine-induced TRPA1 desensitization model. Desensitization of TRPA1 positive nociceptors resulted in damaged mucosal lining, resultant increase in gut permeability and altered transcriptional profile of genes for goblet cell markers, mucus regulation, immune response and tight junction proteins. The damage to mucosal lining prevented its role in enterosyne (short chain fatty acids) actions. Conclusion: These results suggest that caution may need to be exercised before employing TRPA1 desensitization as a therapeutic option to alleviate pain caused due to IBD." @default.
- W3207777372 created "2021-10-25" @default.
- W3207777372 creator A5021690758 @default.
- W3207777372 creator A5033503327 @default.
- W3207777372 creator A5034354976 @default.
- W3207777372 creator A5041030221 @default.
- W3207777372 creator A5045238033 @default.
- W3207777372 creator A5061706236 @default.
- W3207777372 creator A5061984861 @default.
- W3207777372 creator A5070643862 @default.
- W3207777372 creator A5078622214 @default.
- W3207777372 date "2021-10-18" @default.
- W3207777372 modified "2023-10-16" @default.
- W3207777372 title "Colon Innervating TRPA1 Positive Nociceptors Influence Mucosal Health In Mice" @default.
- W3207777372 cites W1604746211 @default.
- W3207777372 cites W1882231731 @default.
- W3207777372 cites W1988239239 @default.
- W3207777372 cites W2045213866 @default.
- W3207777372 cites W2062993520 @default.
- W3207777372 cites W2071657406 @default.
- W3207777372 cites W2078213602 @default.
- W3207777372 cites W2093348737 @default.
- W3207777372 cites W2107277218 @default.
- W3207777372 cites W2145876389 @default.
- W3207777372 cites W2253891902 @default.
- W3207777372 cites W2338467621 @default.
- W3207777372 cites W2416527804 @default.
- W3207777372 cites W2482094715 @default.
- W3207777372 cites W2523555630 @default.
- W3207777372 cites W27282067 @default.
- W3207777372 cites W2749498758 @default.
- W3207777372 cites W2788398310 @default.
- W3207777372 cites W2885834596 @default.
- W3207777372 cites W2891370960 @default.
- W3207777372 cites W2896721795 @default.
- W3207777372 cites W2904505935 @default.
- W3207777372 cites W2913564585 @default.
- W3207777372 cites W2948224329 @default.
- W3207777372 cites W3001402830 @default.
- W3207777372 cites W3008030891 @default.
- W3207777372 cites W3027118763 @default.
- W3207777372 cites W3027443126 @default.
- W3207777372 cites W3035704217 @default.
- W3207777372 cites W3041244286 @default.
- W3207777372 cites W3086607780 @default.
- W3207777372 cites W3098060537 @default.
- W3207777372 cites W3163462840 @default.
- W3207777372 doi "https://doi.org/10.1101/2021.10.17.464752" @default.
- W3207777372 hasPublicationYear "2021" @default.
- W3207777372 type Work @default.
- W3207777372 sameAs 3207777372 @default.
- W3207777372 citedByCount "0" @default.
- W3207777372 crossrefType "posted-content" @default.
- W3207777372 hasAuthorship W3207777372A5021690758 @default.
- W3207777372 hasAuthorship W3207777372A5033503327 @default.
- W3207777372 hasAuthorship W3207777372A5034354976 @default.
- W3207777372 hasAuthorship W3207777372A5041030221 @default.
- W3207777372 hasAuthorship W3207777372A5045238033 @default.
- W3207777372 hasAuthorship W3207777372A5061706236 @default.
- W3207777372 hasAuthorship W3207777372A5061984861 @default.
- W3207777372 hasAuthorship W3207777372A5070643862 @default.
- W3207777372 hasAuthorship W3207777372A5078622214 @default.
- W3207777372 hasBestOaLocation W32077773721 @default.
- W3207777372 hasConcept C118303440 @default.
- W3207777372 hasConcept C126322002 @default.
- W3207777372 hasConcept C15490471 @default.
- W3207777372 hasConcept C155164980 @default.
- W3207777372 hasConcept C160145004 @default.
- W3207777372 hasConcept C170493617 @default.
- W3207777372 hasConcept C172659308 @default.
- W3207777372 hasConcept C18903297 @default.
- W3207777372 hasConcept C203014093 @default.
- W3207777372 hasConcept C2776533618 @default.
- W3207777372 hasConcept C2777312293 @default.
- W3207777372 hasConcept C2778271842 @default.
- W3207777372 hasConcept C2779932011 @default.
- W3207777372 hasConcept C2780071552 @default.
- W3207777372 hasConcept C2780512811 @default.
- W3207777372 hasConcept C2781071285 @default.
- W3207777372 hasConcept C49039625 @default.
- W3207777372 hasConcept C539455810 @default.
- W3207777372 hasConcept C71924100 @default.
- W3207777372 hasConcept C86803240 @default.
- W3207777372 hasConceptScore W3207777372C118303440 @default.
- W3207777372 hasConceptScore W3207777372C126322002 @default.
- W3207777372 hasConceptScore W3207777372C15490471 @default.
- W3207777372 hasConceptScore W3207777372C155164980 @default.
- W3207777372 hasConceptScore W3207777372C160145004 @default.
- W3207777372 hasConceptScore W3207777372C170493617 @default.
- W3207777372 hasConceptScore W3207777372C172659308 @default.
- W3207777372 hasConceptScore W3207777372C18903297 @default.
- W3207777372 hasConceptScore W3207777372C203014093 @default.
- W3207777372 hasConceptScore W3207777372C2776533618 @default.
- W3207777372 hasConceptScore W3207777372C2777312293 @default.
- W3207777372 hasConceptScore W3207777372C2778271842 @default.
- W3207777372 hasConceptScore W3207777372C2779932011 @default.
- W3207777372 hasConceptScore W3207777372C2780071552 @default.
- W3207777372 hasConceptScore W3207777372C2780512811 @default.
- W3207777372 hasConceptScore W3207777372C2781071285 @default.
- W3207777372 hasConceptScore W3207777372C49039625 @default.