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• W3207780205 endingPage "3884" @default.
• W3207780205 startingPage "3873" @default.
• W3207780205 abstract "Cholesterol is integral to the structure of mammalian cell membranes. Oxidation of cholesterol alters how it behaves in the membrane and influences the membrane biophysical properties. Elevated levels of oxidized cholesterol are associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and Huntington's disease. Previous work has investigated the impact of oxidized cholesterol in the context of simple model membrane systems. However, there is a growing body of literature that shows that complex membranes possessing physiological phospholipid distributions have different properties from those of binary or trinary model membranes. In the current work, the impact of oxidized cholesterol on the biophysical properties of a complex neuronal plasma membrane is investigated using coarse-grained Martini molecular dynamics simulations. Comparison of the native neuronal membrane to neuronal membranes containing 10% tail-oxidized or 10% head-oxidized cholesterol shows that the site of oxidization changes the behavior of the oxidized cholesterol in the membrane. Furthermore, species-specific domain formation is observed between each oxidized cholesterol and minor lipid classes. Although both tail-oxidized and head-oxidized cholesterols modulate the biophysical properties of the membrane, smaller changes are observed in the complex neuronal membrane than seen in the previous work on simple binary or trinary model membranes. This work highlights the presence of compensatory effects of lipid diversity in the complex neuronal membrane. Overall, this study improves our molecular-level understanding of the effects of oxidized cholesterol on the properties of neuronal tissue and emphasizes the importance of studying membranes with realistic lipid compositions." @default.
• W3207780205 created "2021-10-25" @default.
• W3207780205 creator A5070546477 @default.
• W3207780205 creator A5075731186 @default.
• W3207780205 creator A5077543727 @default.
• W3207780205 date "2021-10-11" @default.
• W3207780205 modified "2023-10-16" @default.
• W3207780205 title "Site of Cholesterol Oxidation Impacts Its Localization and Domain Formation in the Neuronal Plasma Membrane" @default.
• W3207780205 cites W1031578623 @default.
• W3207780205 cites W1491197989 @default.
• W3207780205 cites W1624860839 @default.
• W3207780205 cites W1948714265 @default.
• W3207780205 cites W1966078827 @default.
• W3207780205 cites W1967786563 @default.
• W3207780205 cites W1968991816 @default.
• W3207780205 cites W1981021420 @default.
• W3207780205 cites W1993083084 @default.
• W3207780205 cites W2001277908 @default.
• W3207780205 cites W2002233682 @default.
• W3207780205 cites W2007616467 @default.
• W3207780205 cites W2013312860 @default.
• W3207780205 cites W2016386918 @default.
• W3207780205 cites W2019036104 @default.
• W3207780205 cites W2023233072 @default.
• W3207780205 cites W2025625972 @default.
• W3207780205 cites W2032429163 @default.
• W3207780205 cites W2046335519 @default.
• W3207780205 cites W2052602536 @default.
• W3207780205 cites W2054406591 @default.
• W3207780205 cites W2063706408 @default.
• W3207780205 cites W2067361016 @default.
• W3207780205 cites W2071458439 @default.
• W3207780205 cites W2073765675 @default.
• W3207780205 cites W2075749349 @default.
• W3207780205 cites W2080054653 @default.
• W3207780205 cites W2081027077 @default.
• W3207780205 cites W2081693079 @default.
• W3207780205 cites W2081995805 @default.
• W3207780205 cites W2082004319 @default.
• W3207780205 cites W2088426105 @default.
• W3207780205 cites W2090233336 @default.
• W3207780205 cites W2092880628 @default.
• W3207780205 cites W2093459572 @default.
• W3207780205 cites W2096200556 @default.
• W3207780205 cites W2103244155 @default.
• W3207780205 cites W2111724662 @default.
• W3207780205 cites W2113574245 @default.
• W3207780205 cites W2119076737 @default.
• W3207780205 cites W2123768693 @default.
• W3207780205 cites W2128775004 @default.
• W3207780205 cites W2128817061 @default.
• W3207780205 cites W2140381533 @default.
• W3207780205 cites W2155195157 @default.
• W3207780205 cites W2160544821 @default.
• W3207780205 cites W2170507717 @default.
• W3207780205 cites W2171268876 @default.
• W3207780205 cites W2178132894 @default.
• W3207780205 cites W2221824803 @default.
• W3207780205 cites W2234444942 @default.
• W3207780205 cites W2296717509 @default.
• W3207780205 cites W2314292783 @default.
• W3207780205 cites W2327174080 @default.
• W3207780205 cites W2493867456 @default.
• W3207780205 cites W2507723354 @default.
• W3207780205 cites W2510200586 @default.
• W3207780205 cites W2529919426 @default.
• W3207780205 cites W2530061921 @default.
• W3207780205 cites W2548225652 @default.
• W3207780205 cites W2550922779 @default.
• W3207780205 cites W2551932359 @default.
• W3207780205 cites W2557951677 @default.
• W3207780205 cites W2745775385 @default.
• W3207780205 cites W2765252959 @default.
• W3207780205 cites W2768803580 @default.
• W3207780205 cites W2782256676 @default.
• W3207780205 cites W2788875385 @default.
• W3207780205 cites W2789905895 @default.
• W3207780205 cites W2805054592 @default.
• W3207780205 cites W2910356247 @default.
• W3207780205 cites W2921583591 @default.
• W3207780205 cites W2944675494 @default.
• W3207780205 cites W2979305182 @default.
• W3207780205 cites W2991711788 @default.
• W3207780205 cites W2999394050 @default.
• W3207780205 cites W3001908863 @default.
• W3207780205 cites W3011631632 @default.
• W3207780205 cites W3044936370 @default.
• W3207780205 cites W3047891029 @default.
• W3207780205 cites W3048515709 @default.
• W3207780205 cites W3071443930 @default.
• W3207780205 cites W3097847796 @default.
• W3207780205 cites W3135310190 @default.
• W3207780205 cites W3137481963 @default.
• W3207780205 cites W3155828254 @default.
• W3207780205 doi "https://doi.org/10.1021/acschemneuro.1c00395" @default.
• W3207780205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34633798" @default.
• W3207780205 hasPublicationYear "2021" @default.
• W3207780205 type Work @default.

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