Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207780892> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3207780892 endingPage "S1163" @default.
- W3207780892 startingPage "S1162" @default.
- W3207780892 abstract "Patients with NSCLC harboring EGFR mutations have good tumor responses with EGFR TKI, however approximately 10% of patients show no disease control. Survival in patients receiving EGFR-TKI is associated with the number of genomic alterations and TMB also been associated with worse clinical outcomes. The importance of co-current genomic alterations detected by foundation one remains to be determined. We decide to explore the importance of co-current alterations in our NSCLC patients with EGFR mutations. In a single center from March 2018 to February 2020 we analyzed prospectively 23 tumor tissue of NSCLC patients with EGFR mutations. Patients were diagnosed with RT PCR, and underwent genotyping using Next generation sequencing platform, Foundation One assay. Kaplan Meier curves were used to evaluate median progression-free survival (PFS) and Overall survival (OS). Twenty three patients were evaluated in this cohort. Mean age was 57. 56.5% patients were never smoker. 13 (56.5%) patients had >3 co-current genomic alterations in the foundation one assay. Adenocarcinoma was the only histological type (100%) and solid pattern the most common subtype (34.8%). Exon 19 del and L858R were the most common mutations. 11 patients received EGFR- TKI as first-line treatment. The most common co- current alteration was TP53 mutation in 12 patients (48%). A ROC curve was done and 3 mutations was related with a difference in survival ( AUC 0.67 sensitivity: 90.3 %, specificity: 71.2%). Median PFS was 36.1 vs 5.1 months in patients with <3 vs >3 mutations (p= 0.013). OS was higher in the <3 mutations group, with median OS of 47 months vs 22 months but this was not significant. (p=0.53) (Figure 1) In NSCLC patients with EGFR mutations treated with EGFR-TKI the presence of three or more genomic alterations evaluated by the Foundation one assay was associated with worse survival." @default.
- W3207780892 created "2021-10-25" @default.
- W3207780892 creator A5002638927 @default.
- W3207780892 creator A5019722638 @default.
- W3207780892 creator A5020080512 @default.
- W3207780892 creator A5029741791 @default.
- W3207780892 creator A5030215194 @default.
- W3207780892 creator A5030772147 @default.
- W3207780892 creator A5035063101 @default.
- W3207780892 creator A5036513860 @default.
- W3207780892 creator A5036788496 @default.
- W3207780892 creator A5067795749 @default.
- W3207780892 creator A5088794873 @default.
- W3207780892 date "2021-10-01" @default.
- W3207780892 modified "2023-10-16" @default.
- W3207780892 title "P59.31 A High Number of Co-Current Genetic Alterations Is Associated With Poor Survival in EGFR Mutated Metastatic NSCLC Patients" @default.
- W3207780892 doi "https://doi.org/10.1016/j.jtho.2021.08.620" @default.
- W3207780892 hasPublicationYear "2021" @default.
- W3207780892 type Work @default.
- W3207780892 sameAs 3207780892 @default.
- W3207780892 citedByCount "0" @default.
- W3207780892 crossrefType "journal-article" @default.
- W3207780892 hasAuthorship W3207780892A5002638927 @default.
- W3207780892 hasAuthorship W3207780892A5019722638 @default.
- W3207780892 hasAuthorship W3207780892A5020080512 @default.
- W3207780892 hasAuthorship W3207780892A5029741791 @default.
- W3207780892 hasAuthorship W3207780892A5030215194 @default.
- W3207780892 hasAuthorship W3207780892A5030772147 @default.
- W3207780892 hasAuthorship W3207780892A5035063101 @default.
- W3207780892 hasAuthorship W3207780892A5036513860 @default.
- W3207780892 hasAuthorship W3207780892A5036788496 @default.
- W3207780892 hasAuthorship W3207780892A5067795749 @default.
- W3207780892 hasAuthorship W3207780892A5088794873 @default.
- W3207780892 hasBestOaLocation W32077808921 @default.
- W3207780892 hasConcept C104317684 @default.
- W3207780892 hasConcept C10515644 @default.
- W3207780892 hasConcept C121608353 @default.
- W3207780892 hasConcept C126322002 @default.
- W3207780892 hasConcept C135763542 @default.
- W3207780892 hasConcept C143998085 @default.
- W3207780892 hasConcept C2781182431 @default.
- W3207780892 hasConcept C31467283 @default.
- W3207780892 hasConcept C501734568 @default.
- W3207780892 hasConcept C54355233 @default.
- W3207780892 hasConcept C71924100 @default.
- W3207780892 hasConcept C72563966 @default.
- W3207780892 hasConcept C86803240 @default.
- W3207780892 hasConceptScore W3207780892C104317684 @default.
- W3207780892 hasConceptScore W3207780892C10515644 @default.
- W3207780892 hasConceptScore W3207780892C121608353 @default.
- W3207780892 hasConceptScore W3207780892C126322002 @default.
- W3207780892 hasConceptScore W3207780892C135763542 @default.
- W3207780892 hasConceptScore W3207780892C143998085 @default.
- W3207780892 hasConceptScore W3207780892C2781182431 @default.
- W3207780892 hasConceptScore W3207780892C31467283 @default.
- W3207780892 hasConceptScore W3207780892C501734568 @default.
- W3207780892 hasConceptScore W3207780892C54355233 @default.
- W3207780892 hasConceptScore W3207780892C71924100 @default.
- W3207780892 hasConceptScore W3207780892C72563966 @default.
- W3207780892 hasConceptScore W3207780892C86803240 @default.
- W3207780892 hasIssue "10" @default.
- W3207780892 hasLocation W32077808921 @default.
- W3207780892 hasOpenAccess W3207780892 @default.
- W3207780892 hasPrimaryLocation W32077808921 @default.
- W3207780892 hasRelatedWork W2080671488 @default.
- W3207780892 hasRelatedWork W2733695800 @default.
- W3207780892 hasRelatedWork W3074585435 @default.
- W3207780892 hasRelatedWork W3128509935 @default.
- W3207780892 hasRelatedWork W3170888641 @default.
- W3207780892 hasRelatedWork W4200188553 @default.
- W3207780892 hasRelatedWork W4250463366 @default.
- W3207780892 hasRelatedWork W4292448967 @default.
- W3207780892 hasRelatedWork W4297961929 @default.
- W3207780892 hasRelatedWork W4362393418 @default.
- W3207780892 hasVolume "16" @default.
- W3207780892 isParatext "false" @default.
- W3207780892 isRetracted "false" @default.
- W3207780892 magId "3207780892" @default.
- W3207780892 workType "article" @default.