FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207788181> ?p ?o ?g. }

• W3207788181 endingPage "A1185" @default.
• W3207788181 startingPage "A1185" @default.
• W3207788181 abstract "TOPIC: Diffuse Lung Disease TYPE: Fellow Case Reports INTRODUCTION: Cigarette smoking is associated with several interstitial lung diseases including desquamative interstitial pneumonia (DIP), respiratory bronchiolitis interstitial lung disease and Pulmonary Langerhan's Cell Histiocytosis. These diseases are known as smoking-related interstitial lung diseases (SR-ILD). Vaping introduced an additional category of SR-ILD known as E-cigarette or vaping associated lung injury (EVALI). We present a case that raised suspicion for concurrent DIP and EVALI in a patient who smoked and vaped. CASE PRESENTATION: A 56 years-old female smoker with a 40-pack-year smoking history presented to the ER with dyspnea and dry cough for two weeks. She had smoked 15 unfiltered self-rolled cigarettes daily but recently switched to packaged cigarettes and vaping in an effort to quit smoking. CT Chest showed ground-glass opacities (GGO) bilaterally (Fig 1). Infectious workup, including sputum culture, was negative. Symptoms improved with antibiotics, steroids, and smoking cessation; repeat CT Chest two months later showed resolution of infiltrates (Fig 2). As symptoms improved, she continued to smoke and vape, presenting with similar symptoms three more times over the following four months requiring hospitalization. Her symptoms responded to steroid treatment and periods of smoking cessation. On her fourth admission, CT chest re-demonstrated bilateral GGO, worse compared to initial imaging (Fig 3). BAL fluid had neutrophilic predominance, pigmented macrophages, and negative cultures. In the setting of recurrent episodes of acute hypoxemic respiratory failure and radiological worsening with re-exposure to smoking and vaping, she was treated for EVALI and DIP with 40 mg of methylprednisolone every eight hours. Her oxygen requirements improved from high flow nasal cannula at FiO2 80% to room air over three days and she was discharged home on a prednisone taper. DISCUSSION: Mortality from DIP ranges from 6-28% while EVALI has independently been associated with nearly 2800 hospitalizations or deaths in a single outbreak. Most cases of EVALI are in smokers and a recent study showed 9.7% of current smokers also vape. Smoking creates an altered pro-inflammatory state of the lung and a secondary insult from toxic aerosolized particles, i.e. vaping, may cause a profound secondary inflammatory response. This case illustrates the importance of screening for a history of vaping in a patient with CT findings suggestive of SR-ILD. As in the present case, DIP and EVALI may be considered steroid-responsive ILDs as well as SR-ILD. CONCLUSIONS: Smokers presenting with respiratory failure and interstitial lung changes should be screened for a history of vaping use. Cessation of both smoking and vaping is crucial in these patients as either may lead to worsening lung injury. Further investigation into dual cases is needed to understand the interplay between smoking-related ILD and EVALI. REFERENCE #1: Carrington, CB et al. Natural history and treated course of usual and desquamative interstitial pneumonia. N Engl J Med. 1978;298:801–809 REFERENCE #2: Villarroel MA, Cha AE, Vahratian A. Electronic cigarette use among U.S. adults, 2018. NCHS Data Brief, no 365. Hyattsville, MD: National Center for Health Statistics. 2020. REFERENCE #3: Kumar, A et al. Current Concepts in Pathogenesis, Diagnosis, and Management of Smoking-Related Interstitial Lung Diseases. Chest. 2018 Aug;154(2):394-408 DISCLOSURES: No relevant relationships by Marilyn Glassberg, source=Web Response No relevant relationships by Nehan Sher, source=Web Response No relevant relationships by Aysha Tandon, source=Web Response" @default.
• W3207788181 created "2021-10-25" @default.
• W3207788181 creator A5046648924 @default.
• W3207788181 creator A5057310012 @default.
• W3207788181 creator A5087322552 @default.
• W3207788181 date "2021-10-01" @default.
• W3207788181 modified "2023-09-25" @default.
• W3207788181 title "ADDING INSULT TO INJURY: E-CIGARETTE OR VAPING PRODUCT USE-ASSOCIATED LUNG INJURY COMBINED WITH SMOKING-RELATED INTERSTITIAL LUNG DISEASE" @default.
• W3207788181 doi "https://doi.org/10.1016/j.chest.2021.07.1088" @default.
• W3207788181 hasPublicationYear "2021" @default.
• W3207788181 type Work @default.
• W3207788181 sameAs 3207788181 @default.
• W3207788181 citedByCount "0" @default.
• W3207788181 crossrefType "journal-article" @default.
• W3207788181 hasAuthorship W3207788181A5046648924 @default.
• W3207788181 hasAuthorship W3207788181A5057310012 @default.
• W3207788181 hasAuthorship W3207788181A5087322552 @default.
• W3207788181 hasBestOaLocation W32077881811 @default.
• W3207788181 hasConcept C126322002 @default.
• W3207788181 hasConcept C141071460 @default.
• W3207788181 hasConcept C142724271 @default.
• W3207788181 hasConcept C2776301714 @default.
• W3207788181 hasConcept C2777543607 @default.
• W3207788181 hasConcept C2777714996 @default.
• W3207788181 hasConcept C2781069245 @default.
• W3207788181 hasConcept C2909011058 @default.
• W3207788181 hasConcept C2909621147 @default.
• W3207788181 hasConcept C71924100 @default.
• W3207788181 hasConcept C9418649 @default.
• W3207788181 hasConceptScore W3207788181C126322002 @default.
• W3207788181 hasConceptScore W3207788181C141071460 @default.
• W3207788181 hasConceptScore W3207788181C142724271 @default.
• W3207788181 hasConceptScore W3207788181C2776301714 @default.
• W3207788181 hasConceptScore W3207788181C2777543607 @default.
• W3207788181 hasConceptScore W3207788181C2777714996 @default.
• W3207788181 hasConceptScore W3207788181C2781069245 @default.
• W3207788181 hasConceptScore W3207788181C2909011058 @default.
• W3207788181 hasConceptScore W3207788181C2909621147 @default.
• W3207788181 hasConceptScore W3207788181C71924100 @default.
• W3207788181 hasConceptScore W3207788181C9418649 @default.
• W3207788181 hasIssue "4" @default.
• W3207788181 hasLocation W32077881811 @default.
• W3207788181 hasOpenAccess W3207788181 @default.
• W3207788181 hasPrimaryLocation W32077881811 @default.
• W3207788181 hasRelatedWork W1966326152 @default.
• W3207788181 hasRelatedWork W2000544067 @default.
• W3207788181 hasRelatedWork W2049179217 @default.
• W3207788181 hasRelatedWork W2057109039 @default.
• W3207788181 hasRelatedWork W2184626375 @default.
• W3207788181 hasRelatedWork W2320667912 @default.
• W3207788181 hasRelatedWork W2906770608 @default.
• W3207788181 hasRelatedWork W3018858604 @default.
• W3207788181 hasRelatedWork W3124847188 @default.
• W3207788181 hasRelatedWork W3166350493 @default.
• W3207788181 hasVolume "160" @default.
• W3207788181 isParatext "false" @default.
• W3207788181 isRetracted "false" @default.
• W3207788181 magId "3207788181" @default.
• W3207788181 workType "article" @default.