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- W3207788598 endingPage "1756.e5" @default.
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- W3207788598 abstract "Interactions between the microbiota and mammalian host are essential for defense against infection, but the microbial-derived cues that mediate this relationship remain unclear. Here, we find that intestinal epithelial cell (IEC)-associated commensal bacteria, segmented filamentous bacteria (SFB), promote early protection against the pathogen Citrobacter rodentium, independent of CD4+ T cells. SFB induced histone modifications in IECs at sites enriched for retinoic acid receptor motifs, suggesting that SFB may enhance defense through retinoic acid (RA). Consistent with this, inhibiting RA signaling suppressed SFB-induced protection. Intestinal RA levels were elevated in SFB mice, despite the inhibition of mammalian RA production, indicating that SFB directly modulate RA. Interestingly, RA was produced by intestinal bacteria, and the loss of bacterial-intrinsic aldehyde dehydrogenase activity decreased the RA levels and increased infection. These data reveal RA as an unexpected microbiota-derived metabolite that primes innate defense and suggests that pre- and probiotic approaches to elevate RA could prevent or combat infections." @default.
- W3207788598 created "2021-10-25" @default.
- W3207788598 creator A5016419362 @default.
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- W3207788598 creator A5087388570 @default.
- W3207788598 date "2021-12-01" @default.
- W3207788598 modified "2023-09-30" @default.
- W3207788598 title "Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection" @default.
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