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- W3207794909 endingPage "5176" @default.
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- W3207794909 abstract "Photodynamic Therapy (PDT) relies on local or systemic administration of a light-sensitive dye, called photosensitizer, to accumulate into the target site followed by excitation with light of appropriate wavelength and fluence. This photo-activated molecule reacts with the intracellular oxygen to induce selective cytotoxicity of targeted cells by the generation of reactive oxygen species. Hepatocellular carcinoma (HCC), one of the leading causes of cancer-associated mortality worldwide, has insufficient treatment options available. In this review, we discuss the mechanism and merits of PDT along with its recent developments as an anti-cancerous therapy. We also highlight the application of this novel therapy for diagnosis, visualization, and treatment of HCC. We examine the underlying challenges, some pre-clinical and clinical studies, and possibilities of future studies associated with PDT. Finally, we discuss the mechanism of an active immune response by PDT and thereafter explored the role of PDT in the generation of anti-tumor immune response in the context of HCC, with an emphasis on checkpoint inhibitor-based immunotherapy. The objective of this review is to propose PDT as a plausible adjuvant to existing therapies for HCC, highlighting a feasible combinatorial approach for HCC treatment." @default.
- W3207794909 created "2021-10-25" @default.
- W3207794909 creator A5004892216 @default.
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- W3207794909 creator A5068165371 @default.
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- W3207794909 date "2021-10-15" @default.
- W3207794909 modified "2023-10-18" @default.
- W3207794909 title "Could Photodynamic Therapy Be a Promising Therapeutic Modality in Hepatocellular Carcinoma Patients? A Critical Review of Experimental and Clinical Studies" @default.
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- W3207794909 doi "https://doi.org/10.3390/cancers13205176" @default.
- W3207794909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8534013" @default.
- W3207794909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34680325" @default.
- W3207794909 hasPublicationYear "2021" @default.
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