Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207816476> ?p ?o ?g. }
- W3207816476 endingPage "27077" @default.
- W3207816476 startingPage "27070" @default.
- W3207816476 abstract "The engagement of unactivated alkyl halides in copper-catalyzed cross-coupling reactions has been historically challenging, due to their low reduction potential and the slow oxidative addition of copper(I) catalysts. In this work, we report a novel strategy that leverages the halogen abstraction ability of aryl radicals, thereby engaging a diverse range of alkyl iodides in copper-catalyzed Negishi-type cross-coupling reactions at room temperature. Specifically, aryl radicals generated via copper catalysis efficiently initiate the cleavage of the carbon-iodide bonds of alkyl iodides. The alkyl radicals thus generated enter the copper catalytic cycles to couple with a difluoromethyl zinc reagent, thus furnishing the alkyl difluoromethane products. This unprecedented Negishi-type difluoromethylation approach has been applied to the late-stage modification of densely functionalized pharmaceutical agents and natural products." @default.
- W3207816476 created "2021-10-25" @default.
- W3207816476 creator A5005469626 @default.
- W3207816476 creator A5045053686 @default.
- W3207816476 creator A5055838753 @default.
- W3207816476 creator A5069368834 @default.
- W3207816476 date "2021-11-17" @default.
- W3207816476 modified "2023-10-05" @default.
- W3207816476 title "Copper‐Catalyzed Difluoromethylation of Alkyl Iodides Enabled by Aryl Radical Activation of Carbon–Iodine Bonds" @default.
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