FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207836178> ?p ?o ?g. }

• W3207836178 endingPage "113626" @default.
• W3207836178 startingPage "113626" @default.
• W3207836178 abstract "In addition to the antidepressant properties of ketamine at subanesthetic doses, studies have revealed ketamine's influence on memory acquisition, consolidation, and reconsolidation. The effects of acute low-dose ketamine administration on conditioned memory have been investigated extensively in rodents through conditioned fear memory and morphine-induced conditioned place preference. In contrast to conditioned memory, the novel object recognition (NOR) task assesses the natural format of memory by exploiting the rodents' natural preference for novelty. Acute low-dose ketamine administration impairs NOR acquisition and consolidation, but its influence on reconsolidation remains unclear. We investigated the issue as well as the involvement of BDNF/TrkB pathway in this process by administering ketamine (i.p., 10 mg/kg, immediately or 6 h after reactivation, or without reactivation) and ANA-12 (i.p., 0.5 mg/kg, 5 min after ketamine/vehicle administration). ANA-12 is a selective antagonist for the BDNF TrkB receptor. Ketamine administration, immediately after (rather than without) reactivation, significantly increased the NOR preference index, thus suggesting an enhanced memory reconsolidation rather than consolidation. Ketamine exerted no significant effect when administered 6 h after reactivation, thereby suggesting 6 h to be an effective time window. ANA-12 administration significantly reduced the ketamine-induced NOR preference index increase, thus suggesting that the blockage of ketamine improves NOR reconsolidation. However, this blockage had no significant effect on the ketamine-induced hippocampal BDNF level increase. In conclusion, acute low-dose ketamine administration improves NOR memory reconsolidation by increasing hippocampal BDNF levels and subsequent BDNF binding to the TrkB receptor." @default.
• W3207836178 created "2021-10-25" @default.
• W3207836178 creator A5001258787 @default.
• W3207836178 creator A5008232261 @default.
• W3207836178 creator A5011877804 @default.
• W3207836178 creator A5018607197 @default.
• W3207836178 creator A5043242031 @default.
• W3207836178 creator A5087028608 @default.
• W3207836178 date "2021-12-01" @default.
• W3207836178 modified "2023-10-17" @default.
• W3207836178 title "Ketamine enhances novel object recognition memory reconsolidation via the BDNF/TrkB pathway in mice" @default.
• W3207836178 cites W1430627820 @default.
• W3207836178 cites W1951169821 @default.
• W3207836178 cites W1981097208 @default.
• W3207836178 cites W2003966687 @default.
• W3207836178 cites W2018457415 @default.
• W3207836178 cites W2023081218 @default.
• W3207836178 cites W2024636695 @default.
• W3207836178 cites W2027844417 @default.
• W3207836178 cites W2050941182 @default.
• W3207836178 cites W2061818436 @default.
• W3207836178 cites W2067047257 @default.
• W3207836178 cites W2076818546 @default.
• W3207836178 cites W2079306370 @default.
• W3207836178 cites W2087336261 @default.
• W3207836178 cites W2089351762 @default.
• W3207836178 cites W2091194550 @default.
• W3207836178 cites W2103218986 @default.
• W3207836178 cites W2162667490 @default.
• W3207836178 cites W2215299382 @default.
• W3207836178 cites W2311108699 @default.
• W3207836178 cites W2336977282 @default.
• W3207836178 cites W2464298446 @default.
• W3207836178 cites W2546531144 @default.
• W3207836178 cites W2593018607 @default.
• W3207836178 cites W2749325587 @default.
• W3207836178 cites W2790275773 @default.
• W3207836178 cites W2803573847 @default.
• W3207836178 cites W2810237872 @default.
• W3207836178 cites W2898929520 @default.
• W3207836178 cites W2902504548 @default.
• W3207836178 cites W2909954110 @default.
• W3207836178 cites W2966375184 @default.
• W3207836178 cites W2988140114 @default.
• W3207836178 cites W3027334221 @default.
• W3207836178 cites W3046435367 @default.
• W3207836178 cites W3088889177 @default.
• W3207836178 cites W3114879417 @default.
• W3207836178 cites W3132500005 @default.
• W3207836178 doi "https://doi.org/10.1016/j.physbeh.2021.113626" @default.
• W3207836178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34673052" @default.
• W3207836178 hasPublicationYear "2021" @default.
• W3207836178 type Work @default.
• W3207836178 sameAs 3207836178 @default.
• W3207836178 citedByCount "4" @default.
• W3207836178 countsByYear W32078361782022 @default.
• W3207836178 countsByYear W32078361782023 @default.
• W3207836178 crossrefType "journal-article" @default.
• W3207836178 hasAuthorship W3207836178A5001258787 @default.
• W3207836178 hasAuthorship W3207836178A5008232261 @default.
• W3207836178 hasAuthorship W3207836178A5011877804 @default.
• W3207836178 hasAuthorship W3207836178A5018607197 @default.
• W3207836178 hasAuthorship W3207836178A5043242031 @default.
• W3207836178 hasAuthorship W3207836178A5087028608 @default.
• W3207836178 hasConcept C126322002 @default.
• W3207836178 hasConcept C148762608 @default.
• W3207836178 hasConcept C15744967 @default.
• W3207836178 hasConcept C160539049 @default.
• W3207836178 hasConcept C169760540 @default.
• W3207836178 hasConcept C170493617 @default.
• W3207836178 hasConcept C2780795376 @default.
• W3207836178 hasConcept C2781161787 @default.
• W3207836178 hasConcept C35124327 @default.
• W3207836178 hasConcept C48455012 @default.
• W3207836178 hasConcept C48856860 @default.
• W3207836178 hasConcept C67018056 @default.
• W3207836178 hasConcept C71924100 @default.
• W3207836178 hasConcept C97124661 @default.
• W3207836178 hasConcept C98274493 @default.
• W3207836178 hasConceptScore W3207836178C126322002 @default.
• W3207836178 hasConceptScore W3207836178C148762608 @default.
• W3207836178 hasConceptScore W3207836178C15744967 @default.
• W3207836178 hasConceptScore W3207836178C160539049 @default.
• W3207836178 hasConceptScore W3207836178C169760540 @default.
• W3207836178 hasConceptScore W3207836178C170493617 @default.
• W3207836178 hasConceptScore W3207836178C2780795376 @default.
• W3207836178 hasConceptScore W3207836178C2781161787 @default.
• W3207836178 hasConceptScore W3207836178C35124327 @default.
• W3207836178 hasConceptScore W3207836178C48455012 @default.
• W3207836178 hasConceptScore W3207836178C48856860 @default.
• W3207836178 hasConceptScore W3207836178C67018056 @default.
• W3207836178 hasConceptScore W3207836178C71924100 @default.
• W3207836178 hasConceptScore W3207836178C97124661 @default.
• W3207836178 hasConceptScore W3207836178C98274493 @default.
• W3207836178 hasLocation W32078361781 @default.
• W3207836178 hasLocation W32078361782 @default.
• W3207836178 hasOpenAccess W3207836178 @default.
• W3207836178 hasPrimaryLocation W32078361781 @default.

• next