FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207848283> ?p ?o ?g. }

• W3207848283 endingPage "2100997" @default.
• W3207848283 startingPage "2100997" @default.
• W3207848283 abstract "Ferroptosis is a new form of regulated cell death, which is characterized by the iron-dependent accumulation of lethal lipid peroxides and involved in many critical diseases. Recent reports revealed that cellular energy metabolism activities such as glycolysis, pentose phosphate pathway (PPP), and tricarboxylic acid cycle are involved in the regulation of key ferroptosis markers such as reduced nicotinamide adenine dinucleotide phosphate (NADPH), glutathione (GSH), and reactive oxygen species (ROS), therefore imposing potential regulatory roles in ferroptosis. Remarkably, tumor cells can activate adaptive metabolic responses to inhibit ferroptosis for self-preservation such as the upregulation of glycolysis and PPP. Due to the rapid proliferation of tumor cells and the intensified metabolic rate, tumor energy metabolism has become a target for disrupting the redox homeostasis and induce ferroptosis. Based on these emerging insights, regulatory impact of those-tumor specific metabolic aberrations is systematically characterized, such as rewired glucose metabolism and metabolic compensation through glutamine utilization on ferroptosis and analyzed the underlying molecular mechanisms. Additionally, those ferroptosis-based therapeutic strategies are also discussed by exploiting those metabolic vulnerabilities, which may open up new avenues for tumor treatment in a clinical context." @default.
• W3207848283 created "2021-10-25" @default.
• W3207848283 creator A5016340724 @default.
• W3207848283 creator A5032997576 @default.
• W3207848283 creator A5042502072 @default.
• W3207848283 creator A5056070630 @default.
• W3207848283 creator A5061897617 @default.
• W3207848283 creator A5072675499 @default.
• W3207848283 creator A5078475480 @default.
• W3207848283 date "2021-10-10" @default.
• W3207848283 modified "2023-10-14" @default.
• W3207848283 title "Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells" @default.
• W3207848283 cites W1513392008 @default.
• W3207848283 cites W1589007430 @default.
• W3207848283 cites W1673751863 @default.
• W3207848283 cites W1975617209 @default.
• W3207848283 cites W1980840552 @default.
• W3207848283 cites W1985197354 @default.
• W3207848283 cites W1987695736 @default.
• W3207848283 cites W1988006764 @default.
• W3207848283 cites W1997183854 @default.
• W3207848283 cites W2002490399 @default.
• W3207848283 cites W2017007251 @default.
• W3207848283 cites W2021793290 @default.
• W3207848283 cites W2023947368 @default.
• W3207848283 cites W2024903578 @default.
• W3207848283 cites W2034530633 @default.
• W3207848283 cites W2035898183 @default.
• W3207848283 cites W2041851797 @default.
• W3207848283 cites W2046100445 @default.
• W3207848283 cites W2054129051 @default.
• W3207848283 cites W2057632732 @default.
• W3207848283 cites W2062459035 @default.
• W3207848283 cites W2067107606 @default.
• W3207848283 cites W2072451938 @default.
• W3207848283 cites W2079854321 @default.
• W3207848283 cites W2080031293 @default.
• W3207848283 cites W2086516047 @default.
• W3207848283 cites W2096982692 @default.
• W3207848283 cites W2097259163 @default.
• W3207848283 cites W2102472842 @default.
• W3207848283 cites W2112912738 @default.
• W3207848283 cites W2114138419 @default.
• W3207848283 cites W2124709834 @default.
• W3207848283 cites W2125258716 @default.
• W3207848283 cites W2125628477 @default.
• W3207848283 cites W2138532680 @default.
• W3207848283 cites W2162420845 @default.
• W3207848283 cites W2163294546 @default.
• W3207848283 cites W2164355096 @default.
• W3207848283 cites W2168024298 @default.
• W3207848283 cites W2239158335 @default.
• W3207848283 cites W2286515888 @default.
• W3207848283 cites W2292613448 @default.
• W3207848283 cites W2345350059 @default.
• W3207848283 cites W2345381093 @default.
• W3207848283 cites W2346316685 @default.
• W3207848283 cites W2470644820 @default.
• W3207848283 cites W2504361340 @default.
• W3207848283 cites W2519942994 @default.
• W3207848283 cites W2549188196 @default.
• W3207848283 cites W2587769401 @default.
• W3207848283 cites W2606811642 @default.
• W3207848283 cites W2606901660 @default.
• W3207848283 cites W2610405998 @default.
• W3207848283 cites W2625887862 @default.
• W3207848283 cites W2738647095 @default.
• W3207848283 cites W2740884150 @default.
• W3207848283 cites W2762087180 @default.
• W3207848283 cites W2762178811 @default.
• W3207848283 cites W2767055857 @default.
• W3207848283 cites W2767281692 @default.
• W3207848283 cites W2769632036 @default.
• W3207848283 cites W2778262854 @default.
• W3207848283 cites W2783764907 @default.
• W3207848283 cites W2789476362 @default.
• W3207848283 cites W2790448745 @default.
• W3207848283 cites W2791235391 @default.
• W3207848283 cites W2794021749 @default.
• W3207848283 cites W2801000404 @default.
• W3207848283 cites W2803912979 @default.
• W3207848283 cites W2804040141 @default.
• W3207848283 cites W2804102163 @default.
• W3207848283 cites W2807803570 @default.
• W3207848283 cites W2884392492 @default.
• W3207848283 cites W2884605745 @default.
• W3207848283 cites W2889646458 @default.
• W3207848283 cites W2890682889 @default.
• W3207848283 cites W2892039303 @default.
• W3207848283 cites W2893234597 @default.
• W3207848283 cites W2906319220 @default.
• W3207848283 cites W2907108901 @default.
• W3207848283 cites W2908456822 @default.
• W3207848283 cites W2912580313 @default.
• W3207848283 cites W2912904788 @default.
• W3207848283 cites W2918245010 @default.
• W3207848283 cites W2918907308 @default.
• W3207848283 cites W2924970449 @default.

• next