Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207866689> ?p ?o ?g. }
- W3207866689 endingPage "108882" @default.
- W3207866689 startingPage "108882" @default.
- W3207866689 abstract "High dietary carbohydrate intake leads to lipid accumulation in the intestinal tract, but the molecular mechanism remains unknown. In the present study, using yellow catfish (Pelteobagrus fulvidraco) as a model, we found that (1) high carbohydrate diets (HCD) and high glucose (HG) increased lipid deposition, up-regulated lipogenesis and fatty acid β-oxidation, activated autophagy and induced oxidative stress in the intestinal tissues and intestinal epithelial cells (IECs); (2) lipophagy alleviated HG-induced lipid accumulation via the up-regulation of fatty acid β-oxidation; (3) Akt interacted directly with Beclin1; (4) HG suppressed Akt1 phosphorylation, downregulated Akt1-mediated phosphorylation of Beclin1, activated lipophagy and alleviated the increment of TG deposition induced by HG with S87 and S292 being the key phosphorylation residues of Beclin1 in response to HG; (5) ROS generation mediated HG-induced activation of lipophagy and HG-induced suppression of AKT phosphorylation, activated AMPK and alleviated HG-induced increase of TG deposition. Our study provides mechanistic evidence that high carbohydrate- and glucose-induced lipophagy in intestine and IECs is associated with ROS-AKT-Beclin1-dependent activation of autophagy, which alleviates glucose-induced lipid accumulation. Our findings are important since the regulation of autophagy can be used as potential molecular targets for the prevention and treatment of lipotoxicity in the intestine of vertebrates, including humans." @default.
- W3207866689 created "2021-10-25" @default.
- W3207866689 creator A5001572861 @default.
- W3207866689 creator A5039380273 @default.
- W3207866689 creator A5040776965 @default.
- W3207866689 creator A5046959003 @default.
- W3207866689 creator A5054095477 @default.
- W3207866689 creator A5064965243 @default.
- W3207866689 creator A5071037763 @default.
- W3207866689 creator A5085562093 @default.
- W3207866689 date "2022-02-01" @default.
- W3207866689 modified "2023-10-16" @default.
- W3207866689 title "Lipophagy mediated glucose-induced changes of lipid deposition and metabolism via ROS dependent AKT-Beclin1 activation" @default.
- W3207866689 cites W1966174134 @default.
- W3207866689 cites W1972542282 @default.
- W3207866689 cites W1984621921 @default.
- W3207866689 cites W1989548787 @default.
- W3207866689 cites W1991720316 @default.
- W3207866689 cites W1992609426 @default.
- W3207866689 cites W1998487027 @default.
- W3207866689 cites W2007505836 @default.
- W3207866689 cites W2009433550 @default.
- W3207866689 cites W2035310767 @default.
- W3207866689 cites W2037840446 @default.
- W3207866689 cites W2040470178 @default.
- W3207866689 cites W2040595737 @default.
- W3207866689 cites W2051732323 @default.
- W3207866689 cites W2053412247 @default.
- W3207866689 cites W2065634680 @default.
- W3207866689 cites W2077418979 @default.
- W3207866689 cites W2084299658 @default.
- W3207866689 cites W2084620758 @default.
- W3207866689 cites W2085097924 @default.
- W3207866689 cites W2086728216 @default.
- W3207866689 cites W2091647998 @default.
- W3207866689 cites W2095499770 @default.
- W3207866689 cites W2113118283 @default.
- W3207866689 cites W2113533472 @default.
- W3207866689 cites W2118157664 @default.
- W3207866689 cites W2139450675 @default.
- W3207866689 cites W2164999828 @default.
- W3207866689 cites W2174107467 @default.
- W3207866689 cites W2177426766 @default.
- W3207866689 cites W2279709351 @default.
- W3207866689 cites W2301313697 @default.
- W3207866689 cites W2324154766 @default.
- W3207866689 cites W2339020769 @default.
- W3207866689 cites W2339832304 @default.
- W3207866689 cites W2567682468 @default.
- W3207866689 cites W2570675177 @default.
- W3207866689 cites W2606187824 @default.
- W3207866689 cites W2607120474 @default.
- W3207866689 cites W2790965810 @default.
- W3207866689 cites W2807936349 @default.
- W3207866689 cites W2884074573 @default.
- W3207866689 cites W2887885556 @default.
- W3207866689 cites W2940087873 @default.
- W3207866689 cites W2948394063 @default.
- W3207866689 cites W2952582160 @default.
- W3207866689 cites W2965405792 @default.
- W3207866689 cites W2965640803 @default.
- W3207866689 cites W2991278498 @default.
- W3207866689 cites W3004095364 @default.
- W3207866689 cites W3011725683 @default.
- W3207866689 cites W3013482226 @default.
- W3207866689 cites W3097003544 @default.
- W3207866689 cites W4230280576 @default.
- W3207866689 cites W2976946254 @default.
- W3207866689 doi "https://doi.org/10.1016/j.jnutbio.2021.108882" @default.
- W3207866689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34655756" @default.
- W3207866689 hasPublicationYear "2022" @default.
- W3207866689 type Work @default.
- W3207866689 sameAs 3207866689 @default.
- W3207866689 citedByCount "8" @default.
- W3207866689 countsByYear W32078666892022 @default.
- W3207866689 countsByYear W32078666892023 @default.
- W3207866689 crossrefType "journal-article" @default.
- W3207866689 hasAuthorship W3207866689A5001572861 @default.
- W3207866689 hasAuthorship W3207866689A5039380273 @default.
- W3207866689 hasAuthorship W3207866689A5040776965 @default.
- W3207866689 hasAuthorship W3207866689A5046959003 @default.
- W3207866689 hasAuthorship W3207866689A5054095477 @default.
- W3207866689 hasAuthorship W3207866689A5064965243 @default.
- W3207866689 hasAuthorship W3207866689A5071037763 @default.
- W3207866689 hasAuthorship W3207866689A5085562093 @default.
- W3207866689 hasConcept C11960822 @default.
- W3207866689 hasConcept C126322002 @default.
- W3207866689 hasConcept C134018914 @default.
- W3207866689 hasConcept C141359234 @default.
- W3207866689 hasConcept C185592680 @default.
- W3207866689 hasConcept C190283241 @default.
- W3207866689 hasConcept C203522944 @default.
- W3207866689 hasConcept C25095133 @default.
- W3207866689 hasConcept C2777391703 @default.
- W3207866689 hasConcept C2779306644 @default.
- W3207866689 hasConcept C2780124434 @default.
- W3207866689 hasConcept C44353895 @default.
- W3207866689 hasConcept C4733338 @default.