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- W3207940703 abstract "Human immunodeficiency virus-1 (HIV-1) can be latent in quiescent CD4+ T cells, in which the viral DNA is silent in transcription and undetectable by the immune system. HIV-1 proviral DNA survives in the latent form primarily in quiescent CD4+ T cells. Although the current antiretroviral therapy (ART) can effectively inhibit the virus replication in HIV-1 infected people and suppress HIV to an undetectable level, ART does not work on latent HIV-1. Therefore, current ART cannot completely cure HIV-1 infected people, and HIV-1 infected people must use life-long ART to inhibit virus replication. Therefore, developing drugs that can act directly on latent HIV-1 is the biggest obstacle to the treatment of HIV-1 infection." @default.
- W3207940703 created "2021-10-25" @default.
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- W3207940703 date "2021-09-24" @default.
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- W3207940703 title "Explore the Future Direction of HIV-1 Latent Virus" @default.
- W3207940703 doi "https://doi.org/10.23977/medsc.2021.020201" @default.
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