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• W3207965988 abstract "The striatum represents the major hub of the basal ganglia, receiving projections from the entire cerebral cortex and it is assumed to play a key role in a wide array of complex behavioral tasks. Despite being extensively investigated during the last decades, the topographical organization of the striatum is not well understood yet. Ongoing efforts in neuroscience are focused on analyzing striatal anatomy at different spatial scales, to understand how structure relates to function and how derangements of this organization are involved in various neuropsychiatric diseases. While being subdivided at the macroscale level into dorsal and ventral divisions, at a mesoscale level the striatum represents an anatomical continuum sharing the same cellular makeup. At the same time, it is now increasingly ascertained that different striatal compartments show subtle histochemical differences, and their neurons exhibit peculiar patterns of gene expression, supporting functional diversity across the whole basal ganglia circuitry. Such diversity is further supported by afferent connections which are heterogenous both anatomically, as they originate from distributed cortical areas and subcortical structures, and biochemically, as they involve a variety of neurotransmitters. Specifically, the cortico-striatal projection system is topographically organized delineating a functional organization which is maintained throughout the basal ganglia, subserving motor, cognitive and affective behavioral functions. While such functional heterogeneity has been firstly conceptualized as a tripartite organization, with sharply defined limbic, associative and sensorimotor territories within the striatum, it has been proposed that such territories are more likely to fade into one another, delineating a gradient-like organization along medio-lateral and ventro-dorsal axes. However, the molecular and cellular underpinnings of such organization are less understood, and their relations to behavior remains an open question, especially in humans. In this review we aimed at summarizing the available knowledge on striatal organization, especially focusing on how it links structure to function and its alterations in neuropsychiatric diseases. We examined studies conducted on different species, covering a wide array of different methodologies: from tract-tracing and immunohistochemistry to neuroimaging and transcriptomic experiments, aimed at bridging the gap between macroscopic and molecular levels." @default.
• W3207965988 created "2021-10-25" @default.
• W3207965988 creator A5038081258 @default.
• W3207965988 creator A5051182896 @default.
• W3207965988 creator A5059351193 @default.
• W3207965988 creator A5062391924 @default.
• W3207965988 creator A5069889196 @default.
• W3207965988 creator A5074670800 @default.
• W3207965988 creator A5076852145 @default.
• W3207965988 date "2021-10-13" @default.
• W3207965988 modified "2023-10-13" @default.
• W3207965988 title "Striatal topographical organization: Bridging the gap between molecules, connectivity and behavior" @default.
• W3207965988 cites W1513126258 @default.
• W3207965988 cites W1553317920 @default.
• W3207965988 cites W1556167233 @default.
• W3207965988 cites W1760829075 @default.
• W3207965988 cites W1806855318 @default.
• W3207965988 cites W1906118694 @default.
• W3207965988 cites W1910298002 @default.
• W3207965988 cites W1929205930 @default.
• W3207965988 cites W1960561004 @default.
• W3207965988 cites W1964795016 @default.
• W3207965988 cites W1967823110 @default.
• W3207965988 cites W1974557531 @default.
• W3207965988 cites W1974878974 @default.
• W3207965988 cites W1975401347 @default.
• W3207965988 cites W1977343782 @default.
• W3207965988 cites W1978122571 @default.
• W3207965988 cites W1978178248 @default.
• W3207965988 cites W1979040150 @default.
• W3207965988 cites W1979887998 @default.
• W3207965988 cites W1979906070 @default.
• W3207965988 cites W1980208993 @default.
• W3207965988 cites W1983033662 @default.
• W3207965988 cites W1983083967 @default.
• W3207965988 cites W1985001303 @default.
• W3207965988 cites W1985367358 @default.
• W3207965988 cites W1988829918 @default.
• W3207965988 cites W1991304179 @default.
• W3207965988 cites W1991600003 @default.
• W3207965988 cites W1991603311 @default.
• W3207965988 cites W1992522654 @default.
• W3207965988 cites W1992587213 @default.
• W3207965988 cites W1993264807 @default.
• W3207965988 cites W1995978685 @default.
• W3207965988 cites W2001586906 @default.
• W3207965988 cites W2002515081 @default.
• W3207965988 cites W2005112198 @default.
• W3207965988 cites W2005590459 @default.
• W3207965988 cites W2005698271 @default.
• W3207965988 cites W2009676531 @default.
• W3207965988 cites W2011154084 @default.
• W3207965988 cites W2011477540 @default.
• W3207965988 cites W2012187737 @default.
• W3207965988 cites W2014481026 @default.
• W3207965988 cites W2015465857 @default.
• W3207965988 cites W2016217177 @default.
• W3207965988 cites W2016754165 @default.
• W3207965988 cites W2018567924 @default.
• W3207965988 cites W2019062369 @default.
• W3207965988 cites W2020415214 @default.
• W3207965988 cites W2022104671 @default.
• W3207965988 cites W2022764592 @default.
• W3207965988 cites W2029942338 @default.
• W3207965988 cites W2032378574 @default.
• W3207965988 cites W2033579584 @default.
• W3207965988 cites W2035171463 @default.
• W3207965988 cites W2037767456 @default.
• W3207965988 cites W2040087600 @default.
• W3207965988 cites W2041507837 @default.
• W3207965988 cites W2043105055 @default.
• W3207965988 cites W2043207588 @default.
• W3207965988 cites W2049547155 @default.
• W3207965988 cites W2054548833 @default.
• W3207965988 cites W2055655674 @default.
• W3207965988 cites W2057001461 @default.
• W3207965988 cites W2057029832 @default.
• W3207965988 cites W2060588252 @default.
• W3207965988 cites W2065885725 @default.
• W3207965988 cites W2066675696 @default.
• W3207965988 cites W2066976690 @default.
• W3207965988 cites W2067456724 @default.
• W3207965988 cites W2067637201 @default.
• W3207965988 cites W2069640850 @default.
• W3207965988 cites W2070895732 @default.
• W3207965988 cites W2071189762 @default.
• W3207965988 cites W2072347227 @default.
• W3207965988 cites W2075021671 @default.
• W3207965988 cites W2075119726 @default.
• W3207965988 cites W2076792446 @default.
• W3207965988 cites W2077823633 @default.
• W3207965988 cites W2081102141 @default.
• W3207965988 cites W2081837126 @default.
• W3207965988 cites W2083383135 @default.
• W3207965988 cites W2084462975 @default.
• W3207965988 cites W2085553767 @default.
• W3207965988 cites W2087251764 @default.
• W3207965988 cites W2091606982 @default.
• W3207965988 cites W2093103458 @default.
• W3207965988 cites W2099652807 @default.

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