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- W3207971985 abstract "•Paraneoplastic cerebellar degenerations (PCDs) associated to Hodgkin's Lymphoma (HL) often show liquoral or serologic detection of antibodies against DNER antigen. •Unlike what might be thought, ectopic expression of onco-neural DNER antigen by Reed-Sternberg cells has always played a marginal role in pathogenesis of these syndromes, according to previous literature. •Here we report a case of HL with clinico-radiological evidence of PCD, serologic detection of anti–DNER antibodies, and ectopic cytoplasmatic expression of DNER antigen at level of Reed-Sternberg cells. •This exceptionality could provide the basis for further investigation aimed at deepen the pathogenesis of these particular paraneoplastic neurologic syndromes considering the complex HL-related microenvironment. •Paraneoplastic cerebellar degenerations (PCDs) associated to Hodgkin's Lymphoma (HL) often show liquoral or serologic detection of antibodies against DNER antigen. •Unlike what might be thought, ectopic expression of onco-neural DNER antigen by Reed-Sternberg cells has always played a marginal role in pathogenesis of these syndromes, according to previous literature. •Here we report a case of HL with clinico-radiological evidence of PCD, serologic detection of anti–DNER antibodies, and ectopic cytoplasmatic expression of DNER antigen at level of Reed-Sternberg cells. •This exceptionality could provide the basis for further investigation aimed at deepen the pathogenesis of these particular paraneoplastic neurologic syndromes considering the complex HL-related microenvironment." @default.
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- W3207971985 date "2022-02-01" @default.
- W3207971985 modified "2023-10-14" @default.
- W3207971985 title "Hodgkin Lymphoma With Diplopia and Nystagmus: A Paraneoplastic Cerebellar Degeneration With Ectopic Expression of DNER Antigen on Reed-Sternberg Cells" @default.
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- W3207971985 doi "https://doi.org/10.1016/j.clml.2021.09.023" @default.
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