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• W3207977157 abstract "Abstract The transcription factor cyclic-AMP response element-binding protein 1 (CREB1) responds to cAMP level and controls the expression of target genes, which regulates nutrition partitioning. The promoters of CREB1-targeted genes responsive to cAMP have been extensively investigated and characterized with the presence of both cAMP response element and TATA box. Compelling evidence demonstrates that CREB1 also plays an essential role in promoting tumor development. However, only very few genes required for cell survival, proliferation and migration are known to be constitutively regulated by CREB1 in tumors. Their promoters mostly do not harbor any cAMP response element. Thus, it is very likely that CREB1 regulates the expressions of distinct sets of target genes in normal tissues and tumors. The whole gene network constitutively regulated by CREB1 in tumors has remained unrevealed. Here, we employ a systematical and integrative approach to decipher this gene network in the context of both tissue cultured cancer cells and patient samples. We combine transcriptomic, Rank-Rank Hypergeometric Overlap, and Chipseq analysis, to define and characterize CREB1-regulated genes in a multidimensional fashion. A strong cancer relevance of those top-ranked targets, which meet the most stringent criteria, is eventually verified by overall survival analysis of cancer patients. These findings strongly suggest the importance of genes constitutively regulated by CREB1 for their implicative involvement in promoting tumorigenesis." @default.
• W3207977157 created "2021-10-25" @default.
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• W3207977157 date "2021-10-12" @default.
• W3207977157 modified "2023-10-14" @default.
• W3207977157 title "Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes" @default.
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• W3207977157 cites W2008134578 @default.
• W3207977157 cites W2009679953 @default.
• W3207977157 cites W2015198866 @default.
• W3207977157 cites W2021449942 @default.
• W3207977157 cites W2028242823 @default.
• W3207977157 cites W2040945369 @default.
• W3207977157 cites W2045435533 @default.
• W3207977157 cites W2047367363 @default.
• W3207977157 cites W2060104845 @default.
• W3207977157 cites W2066662062 @default.
• W3207977157 cites W2083630984 @default.
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• W3207977157 cites W2130091830 @default.
• W3207977157 cites W2136902656 @default.
• W3207977157 cites W2151842875 @default.
• W3207977157 cites W2170551349 @default.
• W3207977157 cites W2171192085 @default.
• W3207977157 cites W2179438025 @default.
• W3207977157 cites W2213239053 @default.
• W3207977157 cites W2224037795 @default.
• W3207977157 cites W2237542949 @default.
• W3207977157 cites W2292747024 @default.
• W3207977157 cites W2313277012 @default.
• W3207977157 cites W2330920071 @default.
• W3207977157 cites W2463587629 @default.
• W3207977157 cites W2554660074 @default.
• W3207977157 cites W2608679299 @default.
• W3207977157 cites W2612584077 @default.
• W3207977157 cites W2619620886 @default.
• W3207977157 cites W2752072744 @default.
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• W3207977157 cites W2808722470 @default.
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• W3207977157 cites W2947030229 @default.
• W3207977157 cites W2952401220 @default.
• W3207977157 cites W2956612201 @default.
• W3207977157 cites W2957388330 @default.
• W3207977157 cites W2963836170 @default.
• W3207977157 cites W2972497510 @default.
• W3207977157 cites W2974920202 @default.
• W3207977157 cites W2985437329 @default.
• W3207977157 cites W2995984143 @default.
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• W3207977157 doi "https://doi.org/10.1186/s12935-021-02224-z" @default.
• W3207977157 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8507136" @default.
• W3207977157 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34641874" @default.
• W3207977157 hasPublicationYear "2021" @default.
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