FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208001768> ?p ?o ?g. }

• W3208001768 endingPage "S806" @default.
• W3208001768 startingPage "S806" @default.
• W3208001768 abstract "Introduction: Colorectal (CR) metastases are an uncommon, though underdiagnosed manifestation of malignancy. There remains a paucity of data to help clinicians understand and identify this clinical entity. Case Description/Methods: A 39-year-old female presented with new onset seizure and was found to have widely metastatic carcinoma of unknown primary (CUP). A PET scan showed diffuse FDG-avid lymphadenopathy and innumerable osseous lesions. An LP showed leptomeningeal disease. EGD was unremarkable. Colonoscopy identified two 2-3mm sessile polyps as well as a 3mm mucosal nodule in the ascending colon which were biopsied with cold forceps. There was also a 12mm sessile polyp in the transverse colon that was incompletely resected using a lift and cut technique with a hot snare. Pathology from all four samples showed high-grade adenocarcinoma with focal signet-ring cells, extensively infiltrating the lamina propria. IHC was undiagnostic for a tissue of origin but was thought to be most consistent with a gynecologic malignancy. She underwent 7 cycles of carbo/taxol before deferring further treatment for palliative care. Discussion: Metastatic lesions to the colon have been estimated to comprise just 1% of total colorectal cancers (1). However, postmortem studies and improved radiographic techniques have suggested that the incidence is higher (2). Multiple malignancies can metastasize to the colon including lung, ovarian, breast, prostate, renal cell carcinoma, and melanoma (1,3,4). Up to 30% of patients with CR metastases are asymptomatic (1) and metastases can spread diffusely below the epithelial layer as was the case with our patient. The development of metastases is a much more stochastic process compared to the stepwise progression from polyp to adenocarcinoma in primary colorectal cancer, and CR metastases may develop rapidly in the interval between screening colonoscopies. Prompt diagnosis of CR metastases provides information on disease extent which can inform prognoses and dictate optimal treatment strategies. Early detection of CR metastases can also help prevent complications such as obstruction, perforation, and bleeding. This case highlights the importance of maintaining a high degree of suspicion for CR metastases even in patients with atypical presentations of malignancy as well as the need for further research to identify tumor and pre-metastatic niche specific factors that predispose to CR metastases.Figure 1.: Colonoscopy pictures. a) Mucosal nodule found in the ascending colon (yellow arrow). b) Sessile polyp found in the ascending colon. c-d) Multiple views of the 12 mm sessile polyp found in transverse colon. e) Lift of the ascending colon polyp was done with Eleview. f) Transverse colon polyp status post polypectomy." @default.
• W3208001768 created "2021-11-08" @default.
• W3208001768 creator A5048048504 @default.
• W3208001768 creator A5059607973 @default.
• W3208001768 creator A5080987118 @default.
• W3208001768 date "2021-10-01" @default.
• W3208001768 modified "2023-10-14" @default.
• W3208001768 title "S1829 Cancer of Unknown Primary Presenting With Colorectal Metastases" @default.
• W3208001768 doi "https://doi.org/10.14309/01.ajg.0000780848.53904.fb" @default.
• W3208001768 hasPublicationYear "2021" @default.
• W3208001768 type Work @default.
• W3208001768 sameAs 3208001768 @default.
• W3208001768 citedByCount "0" @default.
• W3208001768 crossrefType "journal-article" @default.
• W3208001768 hasAuthorship W3208001768A5048048504 @default.
• W3208001768 hasAuthorship W3208001768A5059607973 @default.
• W3208001768 hasAuthorship W3208001768A5080987118 @default.
• W3208001768 hasBestOaLocation W32080017681 @default.
• W3208001768 hasConcept C121332964 @default.
• W3208001768 hasConcept C121608353 @default.
• W3208001768 hasConcept C126322002 @default.
• W3208001768 hasConcept C1276947 @default.
• W3208001768 hasConcept C143998085 @default.
• W3208001768 hasConcept C2777977315 @default.
• W3208001768 hasConcept C3018341830 @default.
• W3208001768 hasConcept C526805850 @default.
• W3208001768 hasConcept C71924100 @default.
• W3208001768 hasConceptScore W3208001768C121332964 @default.
• W3208001768 hasConceptScore W3208001768C121608353 @default.
• W3208001768 hasConceptScore W3208001768C126322002 @default.
• W3208001768 hasConceptScore W3208001768C1276947 @default.
• W3208001768 hasConceptScore W3208001768C143998085 @default.
• W3208001768 hasConceptScore W3208001768C2777977315 @default.
• W3208001768 hasConceptScore W3208001768C3018341830 @default.
• W3208001768 hasConceptScore W3208001768C526805850 @default.
• W3208001768 hasConceptScore W3208001768C71924100 @default.
• W3208001768 hasIssue "1" @default.
• W3208001768 hasLocation W32080017681 @default.
• W3208001768 hasLocation W32080017682 @default.
• W3208001768 hasOpenAccess W3208001768 @default.
• W3208001768 hasPrimaryLocation W32080017681 @default.
• W3208001768 hasRelatedWork W1984432242 @default.
• W3208001768 hasRelatedWork W2004416171 @default.
• W3208001768 hasRelatedWork W2123763668 @default.
• W3208001768 hasRelatedWork W2313837741 @default.
• W3208001768 hasRelatedWork W2388808113 @default.
• W3208001768 hasRelatedWork W2392730113 @default.
• W3208001768 hasRelatedWork W2407964166 @default.
• W3208001768 hasRelatedWork W2416699593 @default.
• W3208001768 hasRelatedWork W3004259476 @default.
• W3208001768 hasRelatedWork W2184744455 @default.
• W3208001768 hasVolume "116" @default.
• W3208001768 isParatext "false" @default.
• W3208001768 isRetracted "false" @default.
• W3208001768 magId "3208001768" @default.
• W3208001768 workType "article" @default.