FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208006160> ?p ?o ?g. }

• W3208006160 endingPage "2100905" @default.
• W3208006160 startingPage "2100905" @default.
• W3208006160 abstract "Biomarkers of unfavourable tuberculosis (TB) treatment outcomes are needed to accelerate new drug and regimen development. Whether plasma cytokine levels can predict unfavourable TB treatment outcomes is unclear.We identified and internally validated the association between 20 a priori selected plasma inflammatory markers and unfavourable treatment outcomes of failure, recurrence and all-cause mortality among adults with drug-sensitive pulmonary TB in India. We externally validated these findings in two independent cohorts of predominantly diabetic and HIV co-infected TB patients in India and South Africa, respectively.Pre-treatment interferon-γ, interleukin (IL)-13 and IL-6 were associated with treatment failure in the discovery analysis. Internal validation confirmed higher pre-treatment IL-6 concentrations among failure cases compared with controls. External validation among predominantly diabetic TB patients found an association between pre-treatment IL-6 concentrations and subsequent recurrence and death. Similarly, external validation among predominantly HIV co-infected TB patients found an association between pre-treatment IL-6 concentrations and subsequent treatment failure and death. In a pooled analysis of 363 TB cases from the Indian and South African validation cohorts, high pre-treatment IL-6 concentrations were associated with higher risk of failure (adjusted OR (aOR) 2.16, 95% CI 1.08-4.33; p=0.02), recurrence (aOR 5.36, 95% CI 2.48-11.57; p<0.001) and death (aOR 4.62, 95% CI 1.95-10.95; p<0.001). Adding baseline IL-6 to a risk prediction model comprised of low body mass index, high smear grade and cavitation improved model performance by 15% (C-statistic 0.66 versus 0.76; p=0.02).Pre-treatment IL-6 is a biomarker for unfavourable TB treatment outcomes. Future studies should identify optimal IL-6 concentrations for point-of-care risk prediction." @default.
• W3208006160 created "2021-11-08" @default.
• W3208006160 creator A5005879554 @default.
• W3208006160 creator A5006779284 @default.
• W3208006160 creator A5011791222 @default.
• W3208006160 creator A5012931164 @default.
• W3208006160 creator A5013968607 @default.
• W3208006160 creator A5022857923 @default.
• W3208006160 creator A5024841283 @default.
• W3208006160 creator A5029089921 @default.
• W3208006160 creator A5030705731 @default.
• W3208006160 creator A5041913334 @default.
• W3208006160 creator A5043005301 @default.
• W3208006160 creator A5043489848 @default.
• W3208006160 creator A5049241758 @default.
• W3208006160 creator A5050158854 @default.
• W3208006160 creator A5051048965 @default.
• W3208006160 creator A5053483302 @default.
• W3208006160 creator A5061419637 @default.
• W3208006160 creator A5065549341 @default.
• W3208006160 creator A5071163040 @default.
• W3208006160 creator A5077213465 @default.
• W3208006160 creator A5079784465 @default.
• W3208006160 creator A5087312973 @default.
• W3208006160 creator A5087559411 @default.
• W3208006160 creator A5088850943 @default.
• W3208006160 date "2021-10-28" @default.
• W3208006160 modified "2023-10-16" @default.
• W3208006160 title "Baseline IL-6 is a biomarker for unfavourable tuberculosis treatment outcomes: a multisite discovery and validation study" @default.
• W3208006160 cites W1968264171 @default.
• W3208006160 cites W1979732039 @default.
• W3208006160 cites W1990823840 @default.
• W3208006160 cites W2011321825 @default.
• W3208006160 cites W2039487466 @default.
• W3208006160 cites W2040520058 @default.
• W3208006160 cites W2045152401 @default.
• W3208006160 cites W2064736441 @default.
• W3208006160 cites W2065059030 @default.
• W3208006160 cites W2073763357 @default.
• W3208006160 cites W2089874034 @default.
• W3208006160 cites W2097147259 @default.
• W3208006160 cites W2146510644 @default.
• W3208006160 cites W2164309428 @default.
• W3208006160 cites W2165951067 @default.
• W3208006160 cites W2296213281 @default.
• W3208006160 cites W2341745603 @default.
• W3208006160 cites W2499731113 @default.
• W3208006160 cites W2612423378 @default.
• W3208006160 cites W2613180822 @default.
• W3208006160 cites W2725423358 @default.
• W3208006160 cites W2738516636 @default.
• W3208006160 cites W2766331800 @default.
• W3208006160 cites W2895784427 @default.
• W3208006160 cites W2991109269 @default.
• W3208006160 cites W3037768701 @default.
• W3208006160 cites W3048182777 @default.
• W3208006160 cites W3093261446 @default.
• W3208006160 cites W3109412101 @default.
• W3208006160 doi "https://doi.org/10.1183/13993003.00905-2021" @default.
• W3208006160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34711538" @default.
• W3208006160 hasPublicationYear "2021" @default.
• W3208006160 type Work @default.
• W3208006160 sameAs 3208006160 @default.
• W3208006160 citedByCount "4" @default.
• W3208006160 countsByYear W32080061602022 @default.
• W3208006160 countsByYear W32080061602023 @default.
• W3208006160 crossrefType "journal-article" @default.
• W3208006160 hasAuthorship W3208006160A5005879554 @default.
• W3208006160 hasAuthorship W3208006160A5006779284 @default.
• W3208006160 hasAuthorship W3208006160A5011791222 @default.
• W3208006160 hasAuthorship W3208006160A5012931164 @default.
• W3208006160 hasAuthorship W3208006160A5013968607 @default.
• W3208006160 hasAuthorship W3208006160A5022857923 @default.
• W3208006160 hasAuthorship W3208006160A5024841283 @default.
• W3208006160 hasAuthorship W3208006160A5029089921 @default.
• W3208006160 hasAuthorship W3208006160A5030705731 @default.
• W3208006160 hasAuthorship W3208006160A5041913334 @default.
• W3208006160 hasAuthorship W3208006160A5043005301 @default.
• W3208006160 hasAuthorship W3208006160A5043489848 @default.
• W3208006160 hasAuthorship W3208006160A5049241758 @default.
• W3208006160 hasAuthorship W3208006160A5050158854 @default.
• W3208006160 hasAuthorship W3208006160A5051048965 @default.
• W3208006160 hasAuthorship W3208006160A5053483302 @default.
• W3208006160 hasAuthorship W3208006160A5061419637 @default.
• W3208006160 hasAuthorship W3208006160A5065549341 @default.
• W3208006160 hasAuthorship W3208006160A5071163040 @default.
• W3208006160 hasAuthorship W3208006160A5077213465 @default.
• W3208006160 hasAuthorship W3208006160A5079784465 @default.
• W3208006160 hasAuthorship W3208006160A5087312973 @default.
• W3208006160 hasAuthorship W3208006160A5087559411 @default.
• W3208006160 hasAuthorship W3208006160A5088850943 @default.
• W3208006160 hasBestOaLocation W32080061602 @default.
• W3208006160 hasConcept C126322002 @default.
• W3208006160 hasConcept C142724271 @default.
• W3208006160 hasConcept C185592680 @default.
• W3208006160 hasConcept C2781069245 @default.
• W3208006160 hasConcept C2781197716 @default.
• W3208006160 hasConcept C2781413609 @default.

• next