FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208011206> ?p ?o ?g. }

• W3208011206 endingPage "1875" @default.
• W3208011206 startingPage "1859" @default.
• W3208011206 abstract "Type 2 DM (T2D) results from the interaction of the genetic and environmental risk factors. Vascular endothelial growth factor (VEGF), angiotensin I-converting enzyme (ACE), and MicroRNAs (MiRNAs) are involved in important physiological processes. Gene variations in VEGF, ACE and MiRNA genes are associated with diseases. In this study we investigated the associations of the VEGF-2578 C/A (rs699947), VEGF-2549 insertion/deletion (I/D), and ACE I/D rs4646994 and Mir128a (rs11888095) gene variations with T2D using the amplification refractory mutation system PCR (ARMS-PCR) and mutation specific PCR (MSP). We screened 122 T2D cases and 126 healthy controls (HCs) for the rs699947, and 133 T2D cases and 133 HCs for the VEGF I/D polymorphism. For the ACE I/D we screened 152 cases and 150 HCs, and we screened 129 cases and 112 HCs for the Mir128a (rs11888095). The results showed that the CA genotype of the VEGF rs699947 and D allele of the VEGF I/D polymorphisms were associated with T2D with OR =2.01, p-value = 0.011, and OR = 2.42, p-value = 0.010, respectively. The result indicated the D allele of the ACE ID was protective against T2D with OR = 0.10, p-value = 0.0001, whereas the TC genotype and the T allele of the Mir128a (rs11888095) were associated with increased risk to T2D with OR = 3.16, p-value = 0.0001, and OR = 1.68, p-value = 0.01, respectively. We conclude that the VEGF (rs699947), VEGF I/D and Mir128a (rs11888095) are potential risk loci for T2D, and that the D allele of the ACE ID polymorphism may be protective against T2D. These results help in identification and stratification for the individuals that at risk for T2D. However, future well-designed studies in different populations and with larger sample sizes are required. Moreover, studies to examine the effects of these polymorphisms on VEGF and ACE proteins are recommended." @default.
• W3208011206 created "2021-11-08" @default.
• W3208011206 creator A5000638849 @default.
• W3208011206 creator A5002456016 @default.
• W3208011206 creator A5005929964 @default.
• W3208011206 creator A5032705974 @default.
• W3208011206 creator A5035667962 @default.
• W3208011206 creator A5049704171 @default.
• W3208011206 creator A5051938978 @default.
• W3208011206 creator A5058703161 @default.
• W3208011206 creator A5060733023 @default.
• W3208011206 creator A5064852873 @default.
• W3208011206 creator A5078514240 @default.
• W3208011206 date "2021-11-02" @default.
• W3208011206 modified "2023-09-30" @default.
• W3208011206 title "Clinical Implications of MiR128, Angiotensin I Converting Enzyme and Vascular Endothelial Growth Factor Gene Abnormalities and Their Association with T2D" @default.
• W3208011206 cites W1971378926 @default.
• W3208011206 cites W1976971215 @default.
• W3208011206 cites W2019874389 @default.
• W3208011206 cites W2024623214 @default.
• W3208011206 cites W2032777249 @default.
• W3208011206 cites W2032982899 @default.
• W3208011206 cites W2038613657 @default.
• W3208011206 cites W2058826795 @default.
• W3208011206 cites W2067049305 @default.
• W3208011206 cites W2088795206 @default.
• W3208011206 cites W2091685401 @default.
• W3208011206 cites W2098828702 @default.
• W3208011206 cites W2103490803 @default.
• W3208011206 cites W2113514532 @default.
• W3208011206 cites W2124780894 @default.
• W3208011206 cites W2126949664 @default.
• W3208011206 cites W2140694423 @default.
• W3208011206 cites W2140961336 @default.
• W3208011206 cites W2147245925 @default.
• W3208011206 cites W2147823235 @default.
• W3208011206 cites W2151612350 @default.
• W3208011206 cites W2340126373 @default.
• W3208011206 cites W2344676185 @default.
• W3208011206 cites W2483176502 @default.
• W3208011206 cites W2544885768 @default.
• W3208011206 cites W2561015265 @default.
• W3208011206 cites W2581652183 @default.
• W3208011206 cites W2590492884 @default.
• W3208011206 cites W2598893736 @default.
• W3208011206 cites W2605245600 @default.
• W3208011206 cites W2625471130 @default.
• W3208011206 cites W2766531428 @default.
• W3208011206 cites W2781716920 @default.
• W3208011206 cites W2791576088 @default.
• W3208011206 cites W2804384059 @default.
• W3208011206 cites W2811212358 @default.
• W3208011206 cites W2884886432 @default.
• W3208011206 cites W2886380990 @default.
• W3208011206 cites W2946853224 @default.
• W3208011206 cites W2948755286 @default.
• W3208011206 cites W2951268956 @default.
• W3208011206 cites W2967393366 @default.
• W3208011206 cites W2970382517 @default.
• W3208011206 cites W2972869264 @default.
• W3208011206 cites W2974058060 @default.
• W3208011206 cites W2981136759 @default.
• W3208011206 cites W2991609417 @default.
• W3208011206 cites W3004520417 @default.
• W3208011206 cites W3004683659 @default.
• W3208011206 cites W3004821841 @default.
• W3208011206 cites W3005021992 @default.
• W3208011206 cites W3017148673 @default.
• W3208011206 cites W3081655479 @default.
• W3208011206 cites W3095518791 @default.
• W3208011206 cites W3113369914 @default.
• W3208011206 cites W3119226380 @default.
• W3208011206 cites W3130888427 @default.
• W3208011206 cites W3153504866 @default.
• W3208011206 cites W3198328734 @default.
• W3208011206 doi "https://doi.org/10.3390/cimb43030130" @default.
• W3208011206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34889890" @default.
• W3208011206 hasPublicationYear "2021" @default.
• W3208011206 type Work @default.
• W3208011206 sameAs 3208011206 @default.
• W3208011206 citedByCount "9" @default.
• W3208011206 countsByYear W32080112062021 @default.
• W3208011206 countsByYear W32080112062022 @default.
• W3208011206 countsByYear W32080112062023 @default.
• W3208011206 crossrefType "journal-article" @default.
• W3208011206 hasAuthorship W3208011206A5000638849 @default.
• W3208011206 hasAuthorship W3208011206A5002456016 @default.
• W3208011206 hasAuthorship W3208011206A5005929964 @default.
• W3208011206 hasAuthorship W3208011206A5032705974 @default.
• W3208011206 hasAuthorship W3208011206A5035667962 @default.
• W3208011206 hasAuthorship W3208011206A5049704171 @default.
• W3208011206 hasAuthorship W3208011206A5051938978 @default.
• W3208011206 hasAuthorship W3208011206A5058703161 @default.
• W3208011206 hasAuthorship W3208011206A5060733023 @default.
• W3208011206 hasAuthorship W3208011206A5064852873 @default.
• W3208011206 hasAuthorship W3208011206A5078514240 @default.
• W3208011206 hasBestOaLocation W32080112061 @default.
• W3208011206 hasConcept C104317684 @default.

• next