Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208032015> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3208032015 abstract "Abstract Peripheral vascular disease (PVD) is a common clinical manifestation of atherosclerosis. Vascular endothelial growth factor (VEGF) gene therapy is a promising approach for PVD treatment. However, due to single-gene therapy limitations and high H 2 O 2 pathological microenvironment, VEGF gene therapy are not as expectations and its clinical application are limited. Synergistic effects of Nerve factors and vascular factors in angiogenesis have attracted attention in recent years. In this study, VEGF and nerve growth factor (NGF) genes co-delivery nanoparticles (VEGF/NGF-NPs) were prepared by using H 2 O 2 responsive 6s-PLGA-Po-PEG as a carrier. 6s-PLGA-Po-PEG could react with H 2 O 2 specifically due to the internal peroxalate bond. Angiogenic effects of VEGF/NGF-NPs has been evaluated in cells and hindlimb ischemia mice model. Results showed that VEGF/NGF-NPs promoted VEGF and NGF co-expression simultaneously, eliminated excessive H 2 O 2 , strengthened reactions between SH-SY5Ys and HUVECs, and finally enhanced migration, tube formation, proliferation and H 2 O 2 damage resistance of HUVECs. VEGF/NGF-NPs also recovered blood perfusion, promoted the expression of VEGF, NGF, eNOS and NO, and enhanced vascular coverage of pericytes. Treatment effects of VEGF/NGF-NPs may related to VEGF/eNOS/NO pathway. Altogether, VEGF/NGF-NPs eliminated excessive H 2 O 2 while achieving gene co-delivery, and promoted stable angiogenesis. It’s a promising way for PVD treatment by using VEGF/NGF-NPs." @default.
- W3208032015 created "2021-11-08" @default.
- W3208032015 creator A5000935397 @default.
- W3208032015 creator A5024070173 @default.
- W3208032015 creator A5036640081 @default.
- W3208032015 creator A5047201427 @default.
- W3208032015 creator A5048419841 @default.
- W3208032015 creator A5054949515 @default.
- W3208032015 creator A5064377514 @default.
- W3208032015 creator A5077833737 @default.
- W3208032015 creator A5081345065 @default.
- W3208032015 creator A5085152562 @default.
- W3208032015 date "2021-11-01" @default.
- W3208032015 modified "2023-10-14" @default.
- W3208032015 title "H2O2-responsive VEGF/NGF gene co-delivery nano-system achieves stable vascularization in ischemic hindlimbs" @default.
- W3208032015 doi "https://doi.org/10.21203/rs.3.rs-994399/v1" @default.
- W3208032015 hasPublicationYear "2021" @default.
- W3208032015 type Work @default.
- W3208032015 sameAs 3208032015 @default.
- W3208032015 citedByCount "0" @default.
- W3208032015 crossrefType "posted-content" @default.
- W3208032015 hasAuthorship W3208032015A5000935397 @default.
- W3208032015 hasAuthorship W3208032015A5024070173 @default.
- W3208032015 hasAuthorship W3208032015A5036640081 @default.
- W3208032015 hasAuthorship W3208032015A5047201427 @default.
- W3208032015 hasAuthorship W3208032015A5048419841 @default.
- W3208032015 hasAuthorship W3208032015A5054949515 @default.
- W3208032015 hasAuthorship W3208032015A5064377514 @default.
- W3208032015 hasAuthorship W3208032015A5077833737 @default.
- W3208032015 hasAuthorship W3208032015A5081345065 @default.
- W3208032015 hasAuthorship W3208032015A5085152562 @default.
- W3208032015 hasBestOaLocation W32080320151 @default.
- W3208032015 hasConcept C104317684 @default.
- W3208032015 hasConcept C111599444 @default.
- W3208032015 hasConcept C126322002 @default.
- W3208032015 hasConcept C134018914 @default.
- W3208032015 hasConcept C135983454 @default.
- W3208032015 hasConcept C146285616 @default.
- W3208032015 hasConcept C167734588 @default.
- W3208032015 hasConcept C170493617 @default.
- W3208032015 hasConcept C185592680 @default.
- W3208032015 hasConcept C2775960820 @default.
- W3208032015 hasConcept C2777025900 @default.
- W3208032015 hasConcept C2777622882 @default.
- W3208032015 hasConcept C2778271429 @default.
- W3208032015 hasConcept C2778326061 @default.
- W3208032015 hasConcept C2778423431 @default.
- W3208032015 hasConcept C2780394083 @default.
- W3208032015 hasConcept C2781188250 @default.
- W3208032015 hasConcept C502942594 @default.
- W3208032015 hasConcept C519581460 @default.
- W3208032015 hasConcept C55493867 @default.
- W3208032015 hasConcept C71924100 @default.
- W3208032015 hasConcept C86803240 @default.
- W3208032015 hasConcept C95444343 @default.
- W3208032015 hasConceptScore W3208032015C104317684 @default.
- W3208032015 hasConceptScore W3208032015C111599444 @default.
- W3208032015 hasConceptScore W3208032015C126322002 @default.
- W3208032015 hasConceptScore W3208032015C134018914 @default.
- W3208032015 hasConceptScore W3208032015C135983454 @default.
- W3208032015 hasConceptScore W3208032015C146285616 @default.
- W3208032015 hasConceptScore W3208032015C167734588 @default.
- W3208032015 hasConceptScore W3208032015C170493617 @default.
- W3208032015 hasConceptScore W3208032015C185592680 @default.
- W3208032015 hasConceptScore W3208032015C2775960820 @default.
- W3208032015 hasConceptScore W3208032015C2777025900 @default.
- W3208032015 hasConceptScore W3208032015C2777622882 @default.
- W3208032015 hasConceptScore W3208032015C2778271429 @default.
- W3208032015 hasConceptScore W3208032015C2778326061 @default.
- W3208032015 hasConceptScore W3208032015C2778423431 @default.
- W3208032015 hasConceptScore W3208032015C2780394083 @default.
- W3208032015 hasConceptScore W3208032015C2781188250 @default.
- W3208032015 hasConceptScore W3208032015C502942594 @default.
- W3208032015 hasConceptScore W3208032015C519581460 @default.
- W3208032015 hasConceptScore W3208032015C55493867 @default.
- W3208032015 hasConceptScore W3208032015C71924100 @default.
- W3208032015 hasConceptScore W3208032015C86803240 @default.
- W3208032015 hasConceptScore W3208032015C95444343 @default.
- W3208032015 hasLocation W32080320151 @default.
- W3208032015 hasLocation W32080320152 @default.
- W3208032015 hasOpenAccess W3208032015 @default.
- W3208032015 hasPrimaryLocation W32080320151 @default.
- W3208032015 hasRelatedWork W1992473983 @default.
- W3208032015 hasRelatedWork W2028797142 @default.
- W3208032015 hasRelatedWork W2035395950 @default.
- W3208032015 hasRelatedWork W2112359061 @default.
- W3208032015 hasRelatedWork W2349324426 @default.
- W3208032015 hasRelatedWork W2417314551 @default.
- W3208032015 hasRelatedWork W2473663846 @default.
- W3208032015 hasRelatedWork W3208032015 @default.
- W3208032015 hasRelatedWork W4220663615 @default.
- W3208032015 hasRelatedWork W73112114 @default.
- W3208032015 isParatext "false" @default.
- W3208032015 isRetracted "false" @default.
- W3208032015 magId "3208032015" @default.
- W3208032015 workType "article" @default.