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• W3208035519 endingPage "2983" @default.
• W3208035519 startingPage "2983" @default.
• W3208035519 abstract "It is recognized that a large proportion of eukaryotic RNAs and proteins is not produced from conventional genes but from short and alternative (alt) open reading frames (ORFs) that are not captured by gene prediction programs. Here we present an in silico prediction of altORFs by applying several selecting filters based on evolutionary conservation and annotations of previously characterized altORF peptides. Our work was performed in the Bithorax-complex (BX-C), which was one of the first genomic regions described to contain long non-coding RNAs in Drosophila. We showed that several altORFs could be predicted from coding and non-coding sequences of BX-C. In addition, the selected altORFs encode for proteins that contain several interesting molecular features, such as the presence of transmembrane helices or a general propensity to be rich in short interaction motifs. Of particular interest, one altORF encodes for a protein that contains a peptide sequence found in specific isoforms of two Drosophila Hox proteins. Our work thus suggests that several altORF proteins could be produced from a particular genomic region known for its critical role during Drosophila embryonic development. The molecular signatures of these altORF proteins further suggests that several of them could make numerous protein-protein interactions and be of functional importance in vivo." @default.
• W3208035519 created "2021-11-08" @default.
• W3208035519 creator A5018979016 @default.
• W3208035519 creator A5075249611 @default.
• W3208035519 date "2021-11-02" @default.
• W3208035519 modified "2023-09-27" @default.
• W3208035519 title "In-Depth Annotation of the Drosophila Bithorax-Complex Reveals the Presence of Several Alternative ORFs That Could Encode for Motif-Rich Peptides" @default.
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• W3208035519 doi "https://doi.org/10.3390/cells10112983" @default.
• W3208035519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8616405" @default.
• W3208035519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34831206" @default.
• W3208035519 hasPublicationYear "2021" @default.
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