FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208041483> ?p ?o ?g. }

• W3208041483 abstract "The rck open reading frame (ORF) on the pefI-srgC operon encodes an outer membrane protein responsible for invasion of nonphagocytic cell lines and resistance to complement-mediated killing. Until now, the rck ORF was only detected on the virulence plasmids of three serovars of Salmonella subsp. enterica (i.e., Bovismorbificans, Enteritidis, and Typhimurium). The increasing number of Salmonella genome sequences allowed us to use a combination of reference sequences and whole-genome multilocus sequence typing (wgMLST) data analysis to probe the presence of the operon and of rck in a wide array of isolates belonging to all Salmonella species and subspecies. We established the presence of partial or complete operons in 61 subsp. enterica serovars as well as in 4 other subspecies with various syntenies and frequencies. The rck ORF itself was retrieved in 36 subsp. enterica serovars and in two subspecies with either chromosomal or plasmid-borne localization. It displays high conservation of its sequence within the genus, and we demonstrated that most of the allelic variations identified did not alter the virulence properties of the protein. However, we demonstrated the importance of the residue at position 38 (at the level of the first extracellular loop of the protein) in the invasin function of Rck. Altogether, our results highlight that rck is not restricted to the three formerly identified serovars and could therefore have a more important role in virulence than previously expected. Moreover, this work raises questions about the mechanisms involved in rck acquisition and about virulence plasmid distribution and evolution. IMPORTANCE The foodborne pathogen Salmonella is responsible for a wide variety of pathologies depending on the infected host, the infecting serovars, and its set of virulence factors. However, the implication of each of these virulence factors and their role in the specific host-pathogen interplay are not fully understood. The significance of our research is in determining the distribution of one of these factors, the virulence plasmid-encoded invasin and resistance to complement killing protein Rck. In addition to providing elements of reflection concerning the mechanisms of acquisition of specific virulence genes in certain serotypes, this work will help to understand the role of Rck in the pathogenesis of Salmonella." @default.
• W3208041483 created "2021-11-08" @default.
• W3208041483 creator A5034077442 @default.
• W3208041483 creator A5041730049 @default.
• W3208041483 creator A5066226436 @default.
• W3208041483 creator A5067246274 @default.
• W3208041483 creator A5077118930 @default.
• W3208041483 creator A5077216158 @default.
• W3208041483 creator A5089756557 @default.
• W3208041483 date "2021-10-31" @default.
• W3208041483 modified "2023-10-18" @default.
• W3208041483 title "The Invasin and Complement-Resistance Protein Rck of Salmonella is More Widely Distributed than Previously Expected" @default.
• W3208041483 cites W1569110942 @default.
• W3208041483 cites W1782158986 @default.
• W3208041483 cites W1850124138 @default.
• W3208041483 cites W1870972790 @default.
• W3208041483 cites W1922086601 @default.
• W3208041483 cites W1966267207 @default.
• W3208041483 cites W1978210588 @default.
• W3208041483 cites W1984640298 @default.
• W3208041483 cites W1987436161 @default.
• W3208041483 cites W1994073020 @default.
• W3208041483 cites W2008435446 @default.
• W3208041483 cites W2009703894 @default.
• W3208041483 cites W2015642465 @default.
• W3208041483 cites W2027229485 @default.
• W3208041483 cites W2032520208 @default.
• W3208041483 cites W2033428826 @default.
• W3208041483 cites W2033714947 @default.
• W3208041483 cites W2038662968 @default.
• W3208041483 cites W2040375746 @default.
• W3208041483 cites W2041263597 @default.
• W3208041483 cites W2043274412 @default.
• W3208041483 cites W2047708153 @default.
• W3208041483 cites W2055043387 @default.
• W3208041483 cites W2062477097 @default.
• W3208041483 cites W2068034539 @default.
• W3208041483 cites W2080476814 @default.
• W3208041483 cites W2083739951 @default.
• W3208041483 cites W2114853012 @default.
• W3208041483 cites W2119098877 @default.
• W3208041483 cites W2122030543 @default.
• W3208041483 cites W2139391134 @default.
• W3208041483 cites W2150512732 @default.
• W3208041483 cites W2151574920 @default.
• W3208041483 cites W2153723818 @default.
• W3208041483 cites W2156732879 @default.
• W3208041483 cites W2163949252 @default.
• W3208041483 cites W2164383866 @default.
• W3208041483 cites W2256746807 @default.
• W3208041483 cites W2516240234 @default.
• W3208041483 cites W2693650708 @default.
• W3208041483 cites W2765176074 @default.
• W3208041483 cites W2766946295 @default.
• W3208041483 cites W2770266393 @default.
• W3208041483 cites W2796241996 @default.
• W3208041483 cites W2804822363 @default.
• W3208041483 cites W2898852345 @default.
• W3208041483 cites W2903394252 @default.
• W3208041483 cites W2963349276 @default.
• W3208041483 cites W2964519345 @default.
• W3208041483 cites W2990127928 @default.
• W3208041483 cites W3013709303 @default.
• W3208041483 cites W3097824790 @default.
• W3208041483 cites W3106674620 @default.
• W3208041483 cites W4210985903 @default.
• W3208041483 cites W4243730337 @default.
• W3208041483 doi "https://doi.org/10.1128/spectrum.01457-21" @default.
• W3208041483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8549739" @default.
• W3208041483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34704781" @default.
• W3208041483 hasPublicationYear "2021" @default.
• W3208041483 type Work @default.
• W3208041483 sameAs 3208041483 @default.
• W3208041483 citedByCount "4" @default.
• W3208041483 countsByYear W32080414832022 @default.
• W3208041483 countsByYear W32080414832023 @default.
• W3208041483 crossrefType "journal-article" @default.
• W3208041483 hasAuthorship W3208041483A5034077442 @default.
• W3208041483 hasAuthorship W3208041483A5041730049 @default.
• W3208041483 hasAuthorship W3208041483A5066226436 @default.
• W3208041483 hasAuthorship W3208041483A5067246274 @default.
• W3208041483 hasAuthorship W3208041483A5077118930 @default.
• W3208041483 hasAuthorship W3208041483A5077216158 @default.
• W3208041483 hasAuthorship W3208041483A5089756557 @default.
• W3208041483 hasBestOaLocation W32080414832 @default.
• W3208041483 hasConcept C10389963 @default.
• W3208041483 hasConcept C104317684 @default.
• W3208041483 hasConcept C135763542 @default.
• W3208041483 hasConcept C151730666 @default.
• W3208041483 hasConcept C167625842 @default.
• W3208041483 hasConcept C17966761 @default.
• W3208041483 hasConcept C203075996 @default.
• W3208041483 hasConcept C22744801 @default.
• W3208041483 hasConcept C2779607309 @default.
• W3208041483 hasConcept C2781065037 @default.
• W3208041483 hasConcept C47289529 @default.
• W3208041483 hasConcept C523546767 @default.
• W3208041483 hasConcept C54355233 @default.
• W3208041483 hasConcept C547475151 @default.
• W3208041483 hasConcept C60987743 @default.

• next