FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208049013> ?p ?o ?g. }

• W3208049013 endingPage "485" @default.
• W3208049013 startingPage "481" @default.
• W3208049013 abstract "Chronic myelogenous leukemia (CML) is one of prevalent cancer worldwide. In spite of various designed drugs, chemoresistance remains the main obstacle in cancer cure. Therefore, developing novel strategy for treatment of CML is an urgent need. Fragaceatoxin C (FraC) is novel protein toxin from a sea anemone called actinia fragacea with great impacts against cells by pore formation and disturbing cell membrane integrity. The aim of this study was evaluation of FraC toxin toxicity against K562. The bacteria cells harboring expression‌‌‌‌‌‌‌ vector of FraC were induced by IPTG and purified by Ni2+-NTA sepharose affinity chromatography. Then, purified toxin activity was evaluated using RBC hemolytic test. Eventually, evaluation of FraC cytotoxicity and apoptosis were performed using MTT and flow cytometery assays, respectively. Our results revealed that FraC toxin decreased K562 cells viability in a dose- and time-dependent manner with a whole destroy of cancer cells at 35.00 µg mL-1 after 72 hr. Furthermore, flow cytometery analysis indicated that FraC toxin enhanced necrosis along with apoptosis in K562 cells in a dose dependent manner. We speculated that FraC toxin could be considered as a novel candidate for cancer cell researches and treatments provided that it should be turned into a specific agent by engineering and directing to cancer cell membrane." @default.
• W3208049013 created "2021-11-08" @default.
• W3208049013 creator A5030859349 @default.
• W3208049013 creator A5039777197 @default.
• W3208049013 creator A5044158288 @default.
• W3208049013 creator A5054603305 @default.
• W3208049013 creator A5061283605 @default.
• W3208049013 creator A5072285830 @default.
• W3208049013 date "2021-12-01" @default.
• W3208049013 modified "2023-10-18" @default.
• W3208049013 title "Cytotoxic effect of sea anemone pore-forming toxin on K562 chronic myeloid leukemia cells." @default.
• W3208049013 cites W1971042394 @default.
• W3208049013 cites W2038458076 @default.
• W3208049013 cites W2039322360 @default.
• W3208049013 cites W2050742318 @default.
• W3208049013 cites W2087020662 @default.
• W3208049013 cites W2095304931 @default.
• W3208049013 cites W2110125586 @default.
• W3208049013 cites W2134068468 @default.
• W3208049013 cites W2163728667 @default.
• W3208049013 cites W2521816285 @default.
• W3208049013 cites W2522890919 @default.
• W3208049013 cites W2579194171 @default.
• W3208049013 cites W2579317476 @default.
• W3208049013 cites W2590645692 @default.
• W3208049013 cites W2619677448 @default.
• W3208049013 cites W2793038730 @default.
• W3208049013 cites W2795908250 @default.
• W3208049013 cites W2800159963 @default.
• W3208049013 cites W2890572325 @default.
• W3208049013 cites W2894871613 @default.
• W3208049013 cites W2962232340 @default.
• W3208049013 doi "https://doi.org/10.30466/vrf.2020.115033.2737" @default.
• W3208049013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35529825" @default.
• W3208049013 hasPublicationYear "2021" @default.
• W3208049013 type Work @default.
• W3208049013 sameAs 3208049013 @default.
• W3208049013 citedByCount "0" @default.
• W3208049013 crossrefType "journal-article" @default.
• W3208049013 hasAuthorship W3208049013A5030859349 @default.
• W3208049013 hasAuthorship W3208049013A5039777197 @default.
• W3208049013 hasAuthorship W3208049013A5044158288 @default.
• W3208049013 hasAuthorship W3208049013A5054603305 @default.
• W3208049013 hasAuthorship W3208049013A5061283605 @default.
• W3208049013 hasAuthorship W3208049013A5072285830 @default.
• W3208049013 hasConcept C109316439 @default.
• W3208049013 hasConcept C121608353 @default.
• W3208049013 hasConcept C153911025 @default.
• W3208049013 hasConcept C154317977 @default.
• W3208049013 hasConcept C171122931 @default.
• W3208049013 hasConcept C185592680 @default.
• W3208049013 hasConcept C190283241 @default.
• W3208049013 hasConcept C202751555 @default.
• W3208049013 hasConcept C203014093 @default.
• W3208049013 hasConcept C2777367657 @default.
• W3208049013 hasConcept C2778461978 @default.
• W3208049013 hasConcept C2778729363 @default.
• W3208049013 hasConcept C2780783641 @default.
• W3208049013 hasConcept C502942594 @default.
• W3208049013 hasConcept C53227056 @default.
• W3208049013 hasConcept C54355233 @default.
• W3208049013 hasConcept C553184892 @default.
• W3208049013 hasConcept C55493867 @default.
• W3208049013 hasConcept C86803240 @default.
• W3208049013 hasConcept C96232424 @default.
• W3208049013 hasConceptScore W3208049013C109316439 @default.
• W3208049013 hasConceptScore W3208049013C121608353 @default.
• W3208049013 hasConceptScore W3208049013C153911025 @default.
• W3208049013 hasConceptScore W3208049013C154317977 @default.
• W3208049013 hasConceptScore W3208049013C171122931 @default.
• W3208049013 hasConceptScore W3208049013C185592680 @default.
• W3208049013 hasConceptScore W3208049013C190283241 @default.
• W3208049013 hasConceptScore W3208049013C202751555 @default.
• W3208049013 hasConceptScore W3208049013C203014093 @default.
• W3208049013 hasConceptScore W3208049013C2777367657 @default.
• W3208049013 hasConceptScore W3208049013C2778461978 @default.
• W3208049013 hasConceptScore W3208049013C2778729363 @default.
• W3208049013 hasConceptScore W3208049013C2780783641 @default.
• W3208049013 hasConceptScore W3208049013C502942594 @default.
• W3208049013 hasConceptScore W3208049013C53227056 @default.
• W3208049013 hasConceptScore W3208049013C54355233 @default.
• W3208049013 hasConceptScore W3208049013C553184892 @default.
• W3208049013 hasConceptScore W3208049013C55493867 @default.
• W3208049013 hasConceptScore W3208049013C86803240 @default.
• W3208049013 hasConceptScore W3208049013C96232424 @default.
• W3208049013 hasIssue "4" @default.
• W3208049013 hasLocation W32080490131 @default.
• W3208049013 hasOpenAccess W3208049013 @default.
• W3208049013 hasPrimaryLocation W32080490131 @default.
• W3208049013 hasRelatedWork W106949 @default.
• W3208049013 hasRelatedWork W11259670 @default.
• W3208049013 hasRelatedWork W11631600 @default.
• W3208049013 hasRelatedWork W11833714 @default.
• W3208049013 hasRelatedWork W11983721 @default.
• W3208049013 hasRelatedWork W14066777 @default.
• W3208049013 hasRelatedWork W16224270 @default.
• W3208049013 hasRelatedWork W20179192 @default.
• W3208049013 hasRelatedWork W21172931 @default.

• next