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- W3208051202 abstract "<h2>Abstract</h2> Recent discovery of new disease-defining molecular alterations and development of novel targeted therapies has dramatically changed the classification and management of uterine mesenchymal neoplasms. This review discusses diagnostic updates in endometrial stromal sarcoma, PEComa, uterine tumor resembling ovarian sex cord tumor (UTROSCT), inflammatory myofibroblastic tumor, <i>NTRK</i> fusion uterine sarcoma, <i>COL1A1-PDGFB</i> fusion sarcoma, and SMARC-deficient uterine sarcoma. Key clinical, morphologic, immunophenotypic, and molecular features are reviewed, with emphasis on common differential diagnoses and pitfalls, and their impact on prognosis or management. Where applicable, the role of novel targeted therapies is discussed. A stepwise approach to uterine mesenchymal neoplasms can achieve a proper diagnosis and guide appropriate clinical management in most cases. Nonetheless, given the rarity of these tumors, their overlapping pathologic features, and rapid evolution in their classification and management, we advocate a low threshold for diagnostic consultation." @default.
- W3208051202 created "2021-11-08" @default.
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- W3208051202 date "2021-12-01" @default.
- W3208051202 modified "2023-09-25" @default.
- W3208051202 title "An update in pathologic diagnosis of uterine mesenchymal tumours" @default.
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- W3208051202 doi "https://doi.org/10.1016/j.mpdhp.2021.09.005" @default.
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