Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208056128> ?p ?o ?g. }
- W3208056128 endingPage "103331" @default.
- W3208056128 startingPage "103331" @default.
- W3208056128 abstract "The 2019 coronavirus disease (COVID-19) became a worldwide pandemic with currently no approved effective antiviral drug. Flux balance analysis (FBA) is an efficient method to analyze metabolic networks. Here, FBA was applied on human lung cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to reposition metabolic drugs and drug combinations against the virus replication within the host tissue. Making use of expression data sets of infected lung tissue, genome-scale COVID-19-specific metabolic models were reconstructed. Then, host-specific essential genes and gene-pairs were determined through in silico knockouts that permit reducing the viral biomass production without affecting the host biomass. Key pathways that are associated with COVID-19 severity in lung tissue are related to oxidative stress, ferroptosis and pyrimidine metabolism. By in silico screening of FDA-approved drugs on the putative disease-specific essential genes and gene-pairs, 85 drugs and 52 drug combinations were predicted as promising candidates for COVID-19 (https://github.com/sysbiolux/DCcov)." @default.
- W3208056128 created "2021-11-08" @default.
- W3208056128 creator A5022936776 @default.
- W3208056128 creator A5050871083 @default.
- W3208056128 creator A5057750170 @default.
- W3208056128 date "2021-11-01" @default.
- W3208056128 modified "2023-10-06" @default.
- W3208056128 title "DCcov: Repositioning of drugs and drug combinations for SARS-CoV-2 infected lung through constraint-based modeling" @default.
- W3208056128 cites W1592232168 @default.
- W3208056128 cites W1823460074 @default.
- W3208056128 cites W1969067437 @default.
- W3208056128 cites W1988136571 @default.
- W3208056128 cites W2009282793 @default.
- W3208056128 cites W2044243244 @default.
- W3208056128 cites W2051118371 @default.
- W3208056128 cites W2066918275 @default.
- W3208056128 cites W2078355959 @default.
- W3208056128 cites W2096245011 @default.
- W3208056128 cites W2099291727 @default.
- W3208056128 cites W2099529347 @default.
- W3208056128 cites W2114104545 @default.
- W3208056128 cites W2119523842 @default.
- W3208056128 cites W2122638857 @default.
- W3208056128 cites W2132218677 @default.
- W3208056128 cites W2144589197 @default.
- W3208056128 cites W2146976725 @default.
- W3208056128 cites W2147472054 @default.
- W3208056128 cites W2179438025 @default.
- W3208056128 cites W2315116755 @default.
- W3208056128 cites W2319116535 @default.
- W3208056128 cites W2341128841 @default.
- W3208056128 cites W2345356016 @default.
- W3208056128 cites W2418056440 @default.
- W3208056128 cites W2604527271 @default.
- W3208056128 cites W2762019694 @default.
- W3208056128 cites W2767891136 @default.
- W3208056128 cites W2789128799 @default.
- W3208056128 cites W2890996509 @default.
- W3208056128 cites W2944993265 @default.
- W3208056128 cites W2993258975 @default.
- W3208056128 cites W3001118548 @default.
- W3208056128 cites W3011127849 @default.
- W3208056128 cites W3013365852 @default.
- W3208056128 cites W3013554928 @default.
- W3208056128 cites W3013967177 @default.
- W3208056128 cites W3016207602 @default.
- W3208056128 cites W3016489853 @default.
- W3208056128 cites W3017005382 @default.
- W3208056128 cites W3020412915 @default.
- W3208056128 cites W3021219695 @default.
- W3208056128 cites W3022285953 @default.
- W3208056128 cites W3023787531 @default.
- W3208056128 cites W3023822056 @default.
- W3208056128 cites W3024177957 @default.
- W3208056128 cites W3024458986 @default.
- W3208056128 cites W3025295924 @default.
- W3208056128 cites W3025305522 @default.
- W3208056128 cites W3035586023 @default.
- W3208056128 cites W3036255694 @default.
- W3208056128 cites W3036891376 @default.
- W3208056128 cites W3037899818 @default.
- W3208056128 cites W3038198963 @default.
- W3208056128 cites W3041072511 @default.
- W3208056128 cites W3041886785 @default.
- W3208056128 cites W3045277594 @default.
- W3208056128 cites W3045525233 @default.
- W3208056128 cites W3046483604 @default.
- W3208056128 cites W3046806318 @default.
- W3208056128 cites W3047125225 @default.
- W3208056128 cites W3049657557 @default.
- W3208056128 cites W3072079143 @default.
- W3208056128 cites W3087409770 @default.
- W3208056128 cites W3134078202 @default.
- W3208056128 cites W3136390341 @default.
- W3208056128 cites W3158868742 @default.
- W3208056128 cites W3161160131 @default.
- W3208056128 cites W3164646585 @default.
- W3208056128 cites W4294216483 @default.
- W3208056128 doi "https://doi.org/10.1016/j.isci.2021.103331" @default.
- W3208056128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8536485" @default.
- W3208056128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34723158" @default.
- W3208056128 hasPublicationYear "2021" @default.
- W3208056128 type Work @default.
- W3208056128 sameAs 3208056128 @default.
- W3208056128 citedByCount "14" @default.
- W3208056128 countsByYear W32080561282022 @default.
- W3208056128 countsByYear W32080561282023 @default.
- W3208056128 crossrefType "journal-article" @default.
- W3208056128 hasAuthorship W3208056128A5022936776 @default.
- W3208056128 hasAuthorship W3208056128A5050871083 @default.
- W3208056128 hasAuthorship W3208056128A5057750170 @default.
- W3208056128 hasBestOaLocation W32080561281 @default.
- W3208056128 hasConcept C103637391 @default.
- W3208056128 hasConcept C104317684 @default.
- W3208056128 hasConcept C140704245 @default.
- W3208056128 hasConcept C141231307 @default.
- W3208056128 hasConcept C142724271 @default.
- W3208056128 hasConcept C159047783 @default.