FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208064503> ?p ?o ?g. }

• W3208064503 endingPage "49" @default.
• W3208064503 startingPage "40" @default.
• W3208064503 abstract "Mammalian spermatogenesis is a temperature-sensitive process, and an increase in testicular temperature impairs spermatogenesis. Leptin modulates testicular activity, but the effect of leptin or its synthetic analogue on heat-induced testicular impairment is unclear. We investigated the effects of synthetic leptin peptide (116-130 amides) on testicular activity in heat-stressed mice model. 15 adult mice (25.54 ± 1.43 g) were selected for the study. Ten mice were subjected to a single heat stress treatment (HS) at 43 °C for 15 min by submerging the lower half of the body in a thermostatic water bath. After heat treatment, mice were divided into two groups, the heat-stressed HS group (n = 5) and the second group as HSL, treated with leptin peptide (116-130 amide) for 14 days. The HS group showed a significant (p < 0.05) decline in the GSI (0.25 ± 0.018), Johnsenscore (4.5 ±.19), seminiferous tubule diameter (160.75 ± 10.18 μm), germinal epithelium height, (GEH) (37.5 ± 1.59 μm) compared to the CN (GSI-0.37 ± 0.015; Johnsen score-7.9 ± 0.20; GEH- 73.25 ± 1.29 μm; tubule diameter-230.25 ± 1.39 μm) and the HSL groups (GSI-0.38 ± 0.014; Johnsen' score-8.0 ± 0.32; GEH- 37.5 ± 1.59 μm; tubule diameter-160.75 ± 10.18 μm) groups. Heat treatment significantly (p < 0.05) increased the intra-testicular levels of leptin (HS-20.11 ± 2.1 pg/mg protein; CN-10.50 ± 0.17 pg/mg protein; HSL-12.99 ± 0.52 pg/mg protein) with a reduced level of pStat3, suggesting leptin resistance during testicular hyperthermia. Furthermore, heat treatment was associated with significantly (p < 0.05) decreased germ cell proliferation and reduced circulating testosterone levels (HS-2.69 ± 2.01 ng/mL; CN-7.69 ± 0.32 ng/mL; HSL-5.36 ± 0.73 ng/mL). However, the circulating androstenedione levels showed a significant (p < 0.05) increase in the HS group (0.75 ± 0.03 ng/mL) compared to the CN (0.51 ± 0.02 ng/mL) and HSL (0.57 ± 0.07 ng/mL) groups. Immunolocalisation of 3β-HSD showed moderate to faint staining in the Leydig cells in the HS group compared to the CN and HSL groups. Treatment with leptin peptide resulted in decrease in the intra-testicular leptin levels with increased phosphorylation of Stat3, suggesting improved leptin resistance, which was positively associated with increased germ cell proliferation, elevated testosterone levels, and improved testicular histoarchitecture. Testicular hyperthermia may cause leptin resistance and impaired leptin signalling, decreased testosterone biosynthesis and suppressed spermatogenesis, which could be a manifestation of leptin resistance. Treatment with leptin peptide improves leptin signalling and testicular activity in heat-stressed mice, but the underlying mechanism is still unclear." @default.
• W3208064503 created "2021-11-08" @default.
• W3208064503 creator A5003682130 @default.
• W3208064503 creator A5052511500 @default.
• W3208064503 creator A5059540502 @default.
• W3208064503 date "2022-01-01" @default.
• W3208064503 modified "2023-10-18" @default.
• W3208064503 title "Synthetic leptin c-fragment peptide minimises heat-induced impairment of spermatogenesis in mice via Stat3 signalling" @default.
• W3208064503 cites W1831537768 @default.
• W3208064503 cites W1965142032 @default.
• W3208064503 cites W1978590803 @default.
• W3208064503 cites W1981113781 @default.
• W3208064503 cites W1982100349 @default.
• W3208064503 cites W1996713062 @default.
• W3208064503 cites W2002781251 @default.
• W3208064503 cites W2003004843 @default.
• W3208064503 cites W2010582753 @default.
• W3208064503 cites W2012730414 @default.
• W3208064503 cites W2015479466 @default.
• W3208064503 cites W2020189115 @default.
• W3208064503 cites W2025846514 @default.
• W3208064503 cites W2042535492 @default.
• W3208064503 cites W2073297555 @default.
• W3208064503 cites W2076257950 @default.
• W3208064503 cites W2077115361 @default.
• W3208064503 cites W2078519369 @default.
• W3208064503 cites W2079538912 @default.
• W3208064503 cites W2089542054 @default.
• W3208064503 cites W2094051883 @default.
• W3208064503 cites W2096374348 @default.
• W3208064503 cites W2101746873 @default.
• W3208064503 cites W2103581424 @default.
• W3208064503 cites W2104404441 @default.
• W3208064503 cites W2108158119 @default.
• W3208064503 cites W2108556423 @default.
• W3208064503 cites W2115005228 @default.
• W3208064503 cites W2115967293 @default.
• W3208064503 cites W2121590326 @default.
• W3208064503 cites W2122611826 @default.
• W3208064503 cites W2124283209 @default.
• W3208064503 cites W2130614519 @default.
• W3208064503 cites W2136964546 @default.
• W3208064503 cites W2145282105 @default.
• W3208064503 cites W2149427568 @default.
• W3208064503 cites W2157708868 @default.
• W3208064503 cites W2158574701 @default.
• W3208064503 cites W2160413910 @default.
• W3208064503 cites W2173421874 @default.
• W3208064503 cites W2314628601 @default.
• W3208064503 cites W2340262527 @default.
• W3208064503 cites W2559844102 @default.
• W3208064503 cites W2572749866 @default.
• W3208064503 cites W2577473992 @default.
• W3208064503 cites W2584840157 @default.
• W3208064503 cites W2590195388 @default.
• W3208064503 cites W2608591750 @default.
• W3208064503 cites W2613645688 @default.
• W3208064503 cites W2613816910 @default.
• W3208064503 cites W2768497762 @default.
• W3208064503 cites W2810515525 @default.
• W3208064503 cites W2892850313 @default.
• W3208064503 cites W2904327344 @default.
• W3208064503 cites W2922419178 @default.
• W3208064503 cites W2978086783 @default.
• W3208064503 cites W2995298233 @default.
• W3208064503 cites W3024418549 @default.
• W3208064503 cites W3024991800 @default.
• W3208064503 cites W3036129568 @default.
• W3208064503 cites W3048749865 @default.
• W3208064503 cites W3081275638 @default.
• W3208064503 cites W3083858121 @default.
• W3208064503 cites W3089703358 @default.
• W3208064503 cites W3126144571 @default.
• W3208064503 cites W3131566211 @default.
• W3208064503 cites W3158143775 @default.
• W3208064503 cites W4293247451 @default.
• W3208064503 doi "https://doi.org/10.1016/j.theriogenology.2021.10.028" @default.
• W3208064503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34763177" @default.
• W3208064503 hasPublicationYear "2022" @default.
• W3208064503 type Work @default.
• W3208064503 sameAs 3208064503 @default.
• W3208064503 citedByCount "3" @default.
• W3208064503 countsByYear W32080645032022 @default.
• W3208064503 countsByYear W32080645032023 @default.
• W3208064503 crossrefType "journal-article" @default.
• W3208064503 hasAuthorship W3208064503A5003682130 @default.
• W3208064503 hasAuthorship W3208064503A5052511500 @default.
• W3208064503 hasAuthorship W3208064503A5059540502 @default.
• W3208064503 hasConcept C123765429 @default.
• W3208064503 hasConcept C126322002 @default.
• W3208064503 hasConcept C134018914 @default.
• W3208064503 hasConcept C16685009 @default.
• W3208064503 hasConcept C185592680 @default.
• W3208064503 hasConcept C2778054371 @default.
• W3208064503 hasConcept C2778466210 @default.
• W3208064503 hasConcept C2779281246 @default.
• W3208064503 hasConcept C2780091579 @default.
• W3208064503 hasConcept C2780498532 @default.

• next