FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208081497> ?p ?o ?g. }

• W3208081497 endingPage "118694" @default.
• W3208081497 startingPage "118694" @default.
• W3208081497 abstract "In this paper we provide an overview of the rationale, methods, and preliminary results of the four Connectome Studies Related to Human Disease investigating mood and anxiety disorders. The first study, “Dimensional connectomics of anxious misery” (HCP-DAM), characterizes brain-symptom relations of a transdiagnostic sample of anxious misery disorders. The second study, “Human connectome Project for disordered emotional states” (HCP-DES), tests a hypothesis-driven model of brain circuit dysfunction in a sample of untreated young adults with symptoms of depression and anxiety. The third study, “Perturbation of the treatment resistant depression connectome by fast-acting therapies” (HCP-MDD), quantifies alterations of the structural and functional connectome as a result of three fast-acting interventions: electroconvulsive therapy, serial ketamine therapy, and total sleep deprivation. Finally, the fourth study, “Connectomes related to anxiety and depression in adolescents” (HCP-ADA), investigates developmental trajectories of subtypes of anxiety and depression in adolescence. The four projects use comparable and standardized Human Connectome Project magnetic resonance imaging (MRI) protocols, including structural MRI, diffusion-weighted MRI, and both task and resting state functional MRI. All four projects also conducted comprehensive and convergent clinical and neuropsychological assessments, including (but not limited to) demographic information, clinical diagnoses, symptoms of mood and anxiety disorders, negative and positive affect, cognitive function, and exposure to early life stress. The first round of analyses conducted in the four projects offered novel methods to investigate relations between functional connectomes and self-reports in large datasets, identified new functional correlates of symptoms of mood and anxiety disorders, characterized the trajectory of connectome-symptom profiles over time, and quantified the impact of novel treatments on aberrant connectivity. Taken together, the data obtained and reported by the four Connectome Studies Related to Human Disease investigating mood and anxiety disorders describe a rich constellation of convergent biological, clinical, and behavioral phenotypes that span the peak ages for the onset of emotional disorders. These data are being prepared for open sharing with the scientific community following screens for quality by the Connectome Coordinating Facility (CCF). The CCF also plans to release data from all projects that have been pre-processed using identical state-of-the-art pipelines. The resultant dataset will give researchers the opportunity to pool complementary data across the four projects to study circuit dysfunctions that may underlie mood and anxiety disorders, to map cohesive relations among circuits and symptoms, and to probe how these relations change as a function of age and acute interventions. This large and combined dataset may also be ideal for using data-driven analytic approaches to inform neurobiological targets for future clinical trials and interventions focused on clinical or behavioral outcomes." @default.
• W3208081497 created "2021-11-08" @default.
• W3208081497 creator A5008790623 @default.
• W3208081497 creator A5015485234 @default.
• W3208081497 creator A5016459812 @default.
• W3208081497 creator A5046155146 @default.
• W3208081497 creator A5052087773 @default.
• W3208081497 creator A5055286510 @default.
• W3208081497 creator A5070432869 @default.
• W3208081497 creator A5077054820 @default.
• W3208081497 creator A5083848316 @default.
• W3208081497 creator A5083948964 @default.
• W3208081497 creator A5085440402 @default.
• W3208081497 date "2021-12-01" @default.
• W3208081497 modified "2023-10-16" @default.
• W3208081497 title "Convergence, preliminary findings and future directions across the four human connectome projects investigating mood and anxiety disorders" @default.
• W3208081497 cites W1942495330 @default.
• W3208081497 cites W1952680005 @default.
• W3208081497 cites W1970133878 @default.
• W3208081497 cites W1977465442 @default.
• W3208081497 cites W1983302342 @default.
• W3208081497 cites W2005005859 @default.
• W3208081497 cites W2005900392 @default.
• W3208081497 cites W2007068998 @default.
• W3208081497 cites W2014580286 @default.
• W3208081497 cites W2018013323 @default.
• W3208081497 cites W2020519533 @default.
• W3208081497 cites W2024136406 @default.
• W3208081497 cites W2024729467 @default.
• W3208081497 cites W2025084014 @default.
• W3208081497 cites W2026088841 @default.
• W3208081497 cites W2027570863 @default.
• W3208081497 cites W2071608556 @default.
• W3208081497 cites W2072253935 @default.
• W3208081497 cites W2076299279 @default.
• W3208081497 cites W2077752708 @default.
• W3208081497 cites W2090123983 @default.
• W3208081497 cites W2108040321 @default.
• W3208081497 cites W2109334244 @default.
• W3208081497 cites W2111118992 @default.
• W3208081497 cites W2119314959 @default.
• W3208081497 cites W2126253977 @default.
• W3208081497 cites W2127355972 @default.
• W3208081497 cites W2131398580 @default.
• W3208081497 cites W2134554750 @default.
• W3208081497 cites W2136452491 @default.
• W3208081497 cites W2137202232 @default.
• W3208081497 cites W2140205353 @default.
• W3208081497 cites W2143247032 @default.
• W3208081497 cites W2143443600 @default.
• W3208081497 cites W2146406045 @default.
• W3208081497 cites W2148519294 @default.
• W3208081497 cites W2149402043 @default.
• W3208081497 cites W2153589742 @default.
• W3208081497 cites W2153620456 @default.
• W3208081497 cites W2165020904 @default.
• W3208081497 cites W2169442707 @default.
• W3208081497 cites W2182104458 @default.
• W3208081497 cites W2277120312 @default.
• W3208081497 cites W2341692630 @default.
• W3208081497 cites W2560565629 @default.
• W3208081497 cites W2573340346 @default.
• W3208081497 cites W2583633855 @default.
• W3208081497 cites W2612195800 @default.
• W3208081497 cites W2662725288 @default.
• W3208081497 cites W2763518308 @default.
• W3208081497 cites W2773684004 @default.
• W3208081497 cites W2783788855 @default.
• W3208081497 cites W2789683669 @default.
• W3208081497 cites W2807128602 @default.
• W3208081497 cites W2811386582 @default.
• W3208081497 cites W2888149555 @default.
• W3208081497 cites W2889156786 @default.
• W3208081497 cites W2893411620 @default.
• W3208081497 cites W2896555885 @default.
• W3208081497 cites W2896970273 @default.
• W3208081497 cites W2912654919 @default.
• W3208081497 cites W2921224201 @default.
• W3208081497 cites W2930862415 @default.
• W3208081497 cites W2936613176 @default.
• W3208081497 cites W2950030754 @default.
• W3208081497 cites W2969692821 @default.
• W3208081497 cites W2986842001 @default.
• W3208081497 cites W2995739647 @default.
• W3208081497 cites W3005509104 @default.
• W3208081497 cites W3006626252 @default.
• W3208081497 cites W3009979434 @default.
• W3208081497 cites W3009996296 @default.
• W3208081497 cites W3011145062 @default.
• W3208081497 cites W3012483240 @default.
• W3208081497 cites W3038241450 @default.
• W3208081497 cites W3045558647 @default.
• W3208081497 cites W3047898105 @default.
• W3208081497 cites W3097826373 @default.
• W3208081497 cites W3106654885 @default.
• W3208081497 cites W3122633272 @default.
• W3208081497 cites W3133571193 @default.
• W3208081497 cites W3157917528 @default.

• next