FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208103404> ?p ?o ?g. }

• W3208103404 endingPage "20" @default.
• W3208103404 startingPage "13" @default.
• W3208103404 abstract "Nucleic acid therapeutics have been attracting attention as novel drug discovery modalities for intractable diseases, including amyotrophic lateral sclerosis. This review provides an overview of the current status and prospects of antisense oligonucleotide treatment for amyotrophic lateral sclerosis. Recently, the results of a phase I/II study using the antisense oligonucleotides Tofersen to treat familial amyotrophic lateral sclerosis with superoxide dismutase 1 mutation have been reported. Intrathecal Tofersen administration resulted in a 36% reduction in superoxide dismutase 1 level in the cerebrospinal fluid. Another report described 2 patients with mutant superoxide dismutase 1 treated with an adeno-associated virus encoding a microRNA targeting superoxide dismutase 1. The first patient, who possessed the fast progressive mutant A5V, received a single intrathecal infusion. Although the patient died of respiratory arrest 16 months after treatment, autopsy findings showed a reduction of >90% in superoxide dismutase 1 level in the spinal cord. Clinical trials on antisense oligonucleotide therapies targeting other major amyotrophic lateral sclerosis-causative genes, fused in sarcoma and chromosome 9 open reading frame 72, are ongoing. To attenuate the pathology of TDP-43, strategies targeting regulators of TDP-43 (ataxin 2) and proteins downstream of TDP-43 (stathmin 2) by antisense oligonucleotides are being developed. The advent of nucleic acid therapeutics has enabled to specifically attack the molecules in the amyotrophic lateral sclerosis pathological cascade, expanding the options for therapeutic targets. ANN NEUROL 2022;91:13-20." @default.
• W3208103404 created "2021-11-08" @default.
• W3208103404 creator A5072267178 @default.
• W3208103404 date "2021-11-20" @default.
• W3208103404 modified "2023-10-06" @default.
• W3208103404 title "Promise of Nucleic Acid Therapeutics for Amyotrophic Lateral Sclerosis" @default.
• W3208103404 cites W1137678651 @default.
• W3208103404 cites W1796096082 @default.
• W3208103404 cites W1797572428 @default.
• W3208103404 cites W1904847174 @default.
• W3208103404 cites W1965286266 @default.
• W3208103404 cites W1971047357 @default.
• W3208103404 cites W1978569326 @default.
• W3208103404 cites W1980477780 @default.
• W3208103404 cites W1984496263 @default.
• W3208103404 cites W1984538960 @default.
• W3208103404 cites W2000370819 @default.
• W3208103404 cites W2001436176 @default.
• W3208103404 cites W2004185979 @default.
• W3208103404 cites W2008213051 @default.
• W3208103404 cites W2011396520 @default.
• W3208103404 cites W2016332933 @default.
• W3208103404 cites W2032107666 @default.
• W3208103404 cites W2036532133 @default.
• W3208103404 cites W2038735530 @default.
• W3208103404 cites W2045291659 @default.
• W3208103404 cites W2055270946 @default.
• W3208103404 cites W2062618223 @default.
• W3208103404 cites W2069171272 @default.
• W3208103404 cites W2069350252 @default.
• W3208103404 cites W2073073462 @default.
• W3208103404 cites W2074726646 @default.
• W3208103404 cites W2080964315 @default.
• W3208103404 cites W2083031173 @default.
• W3208103404 cites W2084561728 @default.
• W3208103404 cites W2096386031 @default.
• W3208103404 cites W2101042581 @default.
• W3208103404 cites W2106150419 @default.
• W3208103404 cites W2133759450 @default.
• W3208103404 cites W2135607950 @default.
• W3208103404 cites W2136930242 @default.
• W3208103404 cites W2140595389 @default.
• W3208103404 cites W2149414920 @default.
• W3208103404 cites W2150523249 @default.
• W3208103404 cites W2154945114 @default.
• W3208103404 cites W2155683527 @default.
• W3208103404 cites W2167256464 @default.
• W3208103404 cites W2296809607 @default.
• W3208103404 cites W2308742329 @default.
• W3208103404 cites W2336552245 @default.
• W3208103404 cites W2336601452 @default.
• W3208103404 cites W2338545563 @default.
• W3208103404 cites W2548654043 @default.
• W3208103404 cites W2569718086 @default.
• W3208103404 cites W2606848380 @default.
• W3208103404 cites W2765253110 @default.
• W3208103404 cites W2765483614 @default.
• W3208103404 cites W2767229911 @default.
• W3208103404 cites W2787027993 @default.
• W3208103404 cites W2809989268 @default.
• W3208103404 cites W2885306088 @default.
• W3208103404 cites W2885679472 @default.
• W3208103404 cites W2910480975 @default.
• W3208103404 cites W2947449763 @default.
• W3208103404 cites W2964002636 @default.
• W3208103404 cites W3031070702 @default.
• W3208103404 cites W3035790625 @default.
• W3208103404 cites W3040840440 @default.
• W3208103404 cites W3041917243 @default.
• W3208103404 cites W3049616059 @default.
• W3208103404 cites W3065917483 @default.
• W3208103404 cites W3081311131 @default.
• W3208103404 cites W3126625669 @default.
• W3208103404 cites W3152692563 @default.
• W3208103404 doi "https://doi.org/10.1002/ana.26259" @default.
• W3208103404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34704267" @default.
• W3208103404 hasPublicationYear "2021" @default.
• W3208103404 type Work @default.
• W3208103404 sameAs 3208103404 @default.
• W3208103404 citedByCount "11" @default.
• W3208103404 countsByYear W32081034042021 @default.
• W3208103404 countsByYear W32081034042022 @default.
• W3208103404 countsByYear W32081034042023 @default.
• W3208103404 crossrefType "journal-article" @default.
• W3208103404 hasAuthorship W3208103404A5072267178 @default.
• W3208103404 hasConcept C104317684 @default.
• W3208103404 hasConcept C126322002 @default.
• W3208103404 hasConcept C129312508 @default.
• W3208103404 hasConcept C142724271 @default.
• W3208103404 hasConcept C2775838275 @default.
• W3208103404 hasConcept C2776151105 @default.
• W3208103404 hasConcept C2779134260 @default.
• W3208103404 hasConcept C2780596555 @default.
• W3208103404 hasConcept C502942594 @default.
• W3208103404 hasConcept C55493867 @default.
• W3208103404 hasConcept C71924100 @default.
• W3208103404 hasConcept C86803240 @default.
• W3208103404 hasConceptScore W3208103404C104317684 @default.

• next