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- W3208117633 abstract "Plasma membrane protein trafficking is of fundamental importance for cell function and cell integrity of neurons and includes regulated protein recycling. In this work, we report a novel role of the endoplasmic reticulum (ER) for protein recycling as discovered in trafficking studies of the ion channel TRPL in photoreceptor cells of Drosophila. TRPL is located within the rhabdomeric membrane from where it is endocytosed upon light stimulation and stored in the cell body. Conventional immunohistochemistry as well as stimulated emission depletion super-resolution microscopy revealed TRPL storage at the ER after illumination, suggesting an unusual recycling route of TRPL. Our results also imply that both phospholipase D (PLD) and retromer complex are required for correct recycling of TRPL to the rhabdomeric membrane. Loss of PLD activity in PLD3.1 mutants results in enhanced degradation of TRPL. In the retromer mutant vps35MH20 , TRPL is trapped in a Rab5-positive compartment. Evidenced by epistatic analysis in the double mutant PLD3.1 vps35MH20 , PLD activity precedes retromer function. We propose a model in which PLD and retromer function play key roles in the transport of TRPL to an ER enriched compartment." @default.
- W3208117633 created "2021-11-08" @default.
- W3208117633 creator A5018199043 @default.
- W3208117633 creator A5043004881 @default.
- W3208117633 creator A5044413337 @default.
- W3208117633 creator A5046443377 @default.
- W3208117633 creator A5091270208 @default.
- W3208117633 date "2021-11-10" @default.
- W3208117633 modified "2023-09-24" @default.
- W3208117633 title "Phospholipase D and retromer promote recycling of <scp>TRPL</scp> ion channel via the endoplasmic reticulum" @default.
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