Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208123695> ?p ?o ?g. }
- W3208123695 abstract "Abstract SMC protein complexes structure genomes by extruding DNA loops, but the molecular mechanism that underlies their activity has remained unknown. We show that the active condensin complex entraps the bases of a DNA loop in two separate chambers. Single-molecule and cryo-electron microscopy provide evidence for a power-stroke movement at the first chamber that feeds DNA into the SMC-kleisin ring upon ATP binding, while the second chamber holds on upstream of the same DNA double helix. Unlocking the strict separation of ‘motor’ and ‘anchor’ chambers turns condensin from a one-sided into a bidirectional DNA loop extruder. We conclude that the orientation of two topologically bound DNA segments during the course of the SMC reaction cycle determines the directionality of DNA loop extrusion." @default.
- W3208123695 created "2021-11-08" @default.
- W3208123695 creator A5005058214 @default.
- W3208123695 creator A5006304452 @default.
- W3208123695 creator A5008002629 @default.
- W3208123695 creator A5009196400 @default.
- W3208123695 creator A5028459134 @default.
- W3208123695 creator A5029515997 @default.
- W3208123695 creator A5055219923 @default.
- W3208123695 creator A5075240495 @default.
- W3208123695 creator A5080683252 @default.
- W3208123695 date "2021-10-29" @default.
- W3208123695 modified "2023-10-14" @default.
- W3208123695 title "A hold-and-feed mechanism drives directional DNA loop extrusion by condensin" @default.
- W3208123695 cites W1967696814 @default.
- W3208123695 cites W1971754542 @default.
- W3208123695 cites W2019077723 @default.
- W3208123695 cites W2026920658 @default.
- W3208123695 cites W2028492648 @default.
- W3208123695 cites W2061467829 @default.
- W3208123695 cites W2089736577 @default.
- W3208123695 cites W2107554748 @default.
- W3208123695 cites W2124026197 @default.
- W3208123695 cites W2152562710 @default.
- W3208123695 cites W2153597220 @default.
- W3208123695 cites W2167279371 @default.
- W3208123695 cites W2273733179 @default.
- W3208123695 cites W2390421705 @default.
- W3208123695 cites W2587625522 @default.
- W3208123695 cites W2593511418 @default.
- W3208123695 cites W2612434226 @default.
- W3208123695 cites W2700512636 @default.
- W3208123695 cites W2760449144 @default.
- W3208123695 cites W2761651210 @default.
- W3208123695 cites W2782774915 @default.
- W3208123695 cites W2786390877 @default.
- W3208123695 cites W2788376770 @default.
- W3208123695 cites W2801376357 @default.
- W3208123695 cites W2885656579 @default.
- W3208123695 cites W2894880237 @default.
- W3208123695 cites W2899714098 @default.
- W3208123695 cites W2899721502 @default.
- W3208123695 cites W2900190809 @default.
- W3208123695 cites W2951726997 @default.
- W3208123695 cites W2952236080 @default.
- W3208123695 cites W2953320394 @default.
- W3208123695 cites W2963275370 @default.
- W3208123695 cites W2972120139 @default.
- W3208123695 cites W2977744221 @default.
- W3208123695 cites W2977933365 @default.
- W3208123695 cites W2989713781 @default.
- W3208123695 cites W2991248607 @default.
- W3208123695 cites W2998399076 @default.
- W3208123695 cites W3009665504 @default.
- W3208123695 cites W3024121050 @default.
- W3208123695 cites W3025316148 @default.
- W3208123695 cites W3041943142 @default.
- W3208123695 cites W3046933533 @default.
- W3208123695 cites W3083406432 @default.
- W3208123695 cites W3086608978 @default.
- W3208123695 cites W3103292928 @default.
- W3208123695 cites W3126733217 @default.
- W3208123695 cites W3136389052 @default.
- W3208123695 cites W3177828909 @default.
- W3208123695 cites W3182356517 @default.
- W3208123695 cites W3184281134 @default.
- W3208123695 cites W4210503035 @default.
- W3208123695 doi "https://doi.org/10.1101/2021.10.29.466147" @default.
- W3208123695 hasPublicationYear "2021" @default.
- W3208123695 type Work @default.
- W3208123695 sameAs 3208123695 @default.
- W3208123695 citedByCount "7" @default.
- W3208123695 countsByYear W32081236952021 @default.
- W3208123695 countsByYear W32081236952022 @default.
- W3208123695 crossrefType "posted-content" @default.
- W3208123695 hasAuthorship W3208123695A5005058214 @default.
- W3208123695 hasAuthorship W3208123695A5006304452 @default.
- W3208123695 hasAuthorship W3208123695A5008002629 @default.
- W3208123695 hasAuthorship W3208123695A5009196400 @default.
- W3208123695 hasAuthorship W3208123695A5028459134 @default.
- W3208123695 hasAuthorship W3208123695A5029515997 @default.
- W3208123695 hasAuthorship W3208123695A5055219923 @default.
- W3208123695 hasAuthorship W3208123695A5075240495 @default.
- W3208123695 hasAuthorship W3208123695A5080683252 @default.
- W3208123695 hasBestOaLocation W32081236951 @default.
- W3208123695 hasConcept C114614502 @default.
- W3208123695 hasConcept C115821613 @default.
- W3208123695 hasConcept C121332964 @default.
- W3208123695 hasConcept C12554922 @default.
- W3208123695 hasConcept C155790170 @default.
- W3208123695 hasConcept C160408235 @default.
- W3208123695 hasConcept C184670325 @default.
- W3208123695 hasConcept C185592680 @default.
- W3208123695 hasConcept C18903297 @default.
- W3208123695 hasConcept C191961535 @default.
- W3208123695 hasConcept C2778530040 @default.
- W3208123695 hasConcept C2779965526 @default.
- W3208123695 hasConcept C33923547 @default.
- W3208123695 hasConcept C552990157 @default.
- W3208123695 hasConcept C55493867 @default.