FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208163188> ?p ?o ?g. }

• W3208163188 endingPage "2976" @default.
• W3208163188 startingPage "2976" @default.
• W3208163188 abstract "High-density lipoprotein (HDL) cholesterol levels are closely associated with human health and diseases. To identify genes modulating plasma HDL levels, we integrated HDL measurements and multi-omics data collected from diverse mouse cohorts and combined a list of systems genetics methods, including quantitative trait loci (QTL) mapping analysis, mediation analysis, transcriptome-wide association analysis (TWAS), and correlation analysis. We confirmed a significant and conserved QTL for plasma HDL on chromosome 1 and identified that Tstd1 liver transcript correlates with plasma HDL in several independent mouse cohorts, suggesting Tstd1 may be a potential modulator of plasma HDL levels. Correlation analysis using over 70 transcriptomics datasets in humans and mice revealed consistent correlations between Tstd1 and genes known to be involved in cholesterol and HDL regulation. Consistent with strong enrichment in gene sets related to cholesterol and lipoproteins in the liver, mouse strains with high Tstd1 exhibited higher plasma levels of HDL, total cholesterol and other lipid markers. GeneBridge using large-scale expression datasets identified conserved and positive associations between TSTD1/Tstd1 and mitochondrial pathways, as well as cholesterol and lipid pathways in human, mouse and rat. In summary, we identified Tstd1 as a new modulator of plasma HDL and mitochondrial function through integrative systems analyses, and proposed a new mechanism of HDL modulation and a potential therapeutic target for relevant diseases. This study highlights the value of such integrative approaches in revealing molecular mechanisms of complex traits or diseases." @default.
• W3208163188 created "2021-11-08" @default.
• W3208163188 creator A5019560977 @default.
• W3208163188 creator A5020977961 @default.
• W3208163188 creator A5022920235 @default.
• W3208163188 creator A5085349414 @default.
• W3208163188 date "2021-11-01" @default.
• W3208163188 modified "2023-10-15" @default.
• W3208163188 title "Integrative Analyses Reveal Tstd1 as a Potential Modulator of HDL Cholesterol and Mitochondrial Function in Mice" @default.
• W3208163188 cites W1496411751 @default.
• W3208163188 cites W1964256485 @default.
• W3208163188 cites W1965715040 @default.
• W3208163188 cites W1966327575 @default.
• W3208163188 cites W1969219820 @default.
• W3208163188 cites W1970726947 @default.
• W3208163188 cites W1979080082 @default.
• W3208163188 cites W1982981124 @default.
• W3208163188 cites W1985870224 @default.
• W3208163188 cites W1989277387 @default.
• W3208163188 cites W1993616000 @default.
• W3208163188 cites W2005203528 @default.
• W3208163188 cites W2007991295 @default.
• W3208163188 cites W2013196115 @default.
• W3208163188 cites W2015450538 @default.
• W3208163188 cites W2017685968 @default.
• W3208163188 cites W2017968038 @default.
• W3208163188 cites W2018145766 @default.
• W3208163188 cites W2038607614 @default.
• W3208163188 cites W2043842514 @default.
• W3208163188 cites W2047940046 @default.
• W3208163188 cites W2055729264 @default.
• W3208163188 cites W2059032482 @default.
• W3208163188 cites W2079076614 @default.
• W3208163188 cites W2090217381 @default.
• W3208163188 cites W2110731042 @default.
• W3208163188 cites W2120244696 @default.
• W3208163188 cites W2121296657 @default.
• W3208163188 cites W2122538288 @default.
• W3208163188 cites W2123168196 @default.
• W3208163188 cites W2130410032 @default.
• W3208163188 cites W2134199375 @default.
• W3208163188 cites W2145312132 @default.
• W3208163188 cites W2158534900 @default.
• W3208163188 cites W2158612065 @default.
• W3208163188 cites W2164314951 @default.
• W3208163188 cites W2168548026 @default.
• W3208163188 cites W2169013314 @default.
• W3208163188 cites W2175680864 @default.
• W3208163188 cites W2227149020 @default.
• W3208163188 cites W2252671082 @default.
• W3208163188 cites W2299598005 @default.
• W3208163188 cites W2342116893 @default.
• W3208163188 cites W2434017435 @default.
• W3208163188 cites W2587032172 @default.
• W3208163188 cites W2619392341 @default.
• W3208163188 cites W2744658081 @default.
• W3208163188 cites W2899241243 @default.
• W3208163188 cites W2901507440 @default.
• W3208163188 cites W2903563748 @default.
• W3208163188 cites W2938688210 @default.
• W3208163188 cites W2945581051 @default.
• W3208163188 cites W2950395494 @default.
• W3208163188 cites W2988982548 @default.
• W3208163188 cites W2990465161 @default.
• W3208163188 cites W3004528631 @default.
• W3208163188 cites W3099862724 @default.
• W3208163188 cites W4210476933 @default.
• W3208163188 cites W4231254854 @default.
• W3208163188 doi "https://doi.org/10.3390/cells10112976" @default.
• W3208163188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8616306" @default.
• W3208163188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34831199" @default.
• W3208163188 hasPublicationYear "2021" @default.
• W3208163188 type Work @default.
• W3208163188 sameAs 3208163188 @default.
• W3208163188 citedByCount "1" @default.
• W3208163188 countsByYear W32081631882022 @default.
• W3208163188 crossrefType "journal-article" @default.
• W3208163188 hasAuthorship W3208163188A5019560977 @default.
• W3208163188 hasAuthorship W3208163188A5020977961 @default.
• W3208163188 hasAuthorship W3208163188A5022920235 @default.
• W3208163188 hasAuthorship W3208163188A5085349414 @default.
• W3208163188 hasBestOaLocation W32081631881 @default.
• W3208163188 hasConcept C104317684 @default.
• W3208163188 hasConcept C134018914 @default.
• W3208163188 hasConcept C14036430 @default.
• W3208163188 hasConcept C150194340 @default.
• W3208163188 hasConcept C162317418 @default.
• W3208163188 hasConcept C21565614 @default.
• W3208163188 hasConcept C2778163477 @default.
• W3208163188 hasConcept C54355233 @default.
• W3208163188 hasConcept C60644358 @default.
• W3208163188 hasConcept C70721500 @default.
• W3208163188 hasConcept C81941488 @default.
• W3208163188 hasConcept C86803240 @default.
• W3208163188 hasConceptScore W3208163188C104317684 @default.
• W3208163188 hasConceptScore W3208163188C134018914 @default.
• W3208163188 hasConceptScore W3208163188C14036430 @default.
• W3208163188 hasConceptScore W3208163188C150194340 @default.

• next