Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208163551> ?p ?o ?g. }
Showing items 1 to 43 of
43
with 100 items per page.
- W3208163551 abstract "目的观察木犀草素对MDA-MB-231乳腺癌细胞增殖以及对OPCML基因表达的影响。 方法体外培养MDA-MB-231细胞，加入终浓度为0（对照组）以及5、10和20 μmol/L的木犀草素处理孵育24 h或48 h后，MTT法检测细胞的增殖，流式细胞术检测细胞凋亡；并提取胞内总mRNA和蛋白，以实时定量PCR和Western blot检测OPCML的mRNA及蛋白变化；同时采用甲基化特异性PCR（MSP）检测OPCML启动子区域的甲基化水平，并分析细胞内甲基化酶的活性。 结果MTT结果显示，MDA-MB-231细胞经5、10以及20 μmol/L木犀草素孵育24 h后，随着浓度的递增，细胞活性逐渐降低（P 结论木犀草素可抑制MDA-MB-231乳腺癌细胞的增殖，其机制可能与影响OPCML基因的表达以及甲基化水平有关。" @default.
- W3208163551 created "2021-11-08" @default.
- W3208163551 creator A5006819347 @default.
- W3208163551 creator A5007036695 @default.
- W3208163551 creator A5007425101 @default.
- W3208163551 creator A5015112116 @default.
- W3208163551 creator A5017521861 @default.
- W3208163551 creator A5029254474 @default.
- W3208163551 creator A5029839968 @default.
- W3208163551 creator A5057209439 @default.
- W3208163551 creator A5069973844 @default.
- W3208163551 creator A5078737066 @default.
- W3208163551 creator A5081093152 @default.
- W3208163551 creator A5081402612 @default.
- W3208163551 date "2020-04-20" @default.
- W3208163551 modified "2023-09-23" @default.
- W3208163551 title "木犀草素通过逆转OPCML基因甲基化抑制乳腺癌MDA-MB-231细胞增殖" @default.
- W3208163551 hasPublicationYear "2020" @default.
- W3208163551 type Work @default.
- W3208163551 sameAs 3208163551 @default.
- W3208163551 citedByCount "0" @default.
- W3208163551 crossrefType "journal-article" @default.
- W3208163551 hasAuthorship W3208163551A5006819347 @default.
- W3208163551 hasAuthorship W3208163551A5007036695 @default.
- W3208163551 hasAuthorship W3208163551A5007425101 @default.
- W3208163551 hasAuthorship W3208163551A5015112116 @default.
- W3208163551 hasAuthorship W3208163551A5017521861 @default.
- W3208163551 hasAuthorship W3208163551A5029254474 @default.
- W3208163551 hasAuthorship W3208163551A5029839968 @default.
- W3208163551 hasAuthorship W3208163551A5057209439 @default.
- W3208163551 hasAuthorship W3208163551A5069973844 @default.
- W3208163551 hasAuthorship W3208163551A5078737066 @default.
- W3208163551 hasAuthorship W3208163551A5081093152 @default.
- W3208163551 hasAuthorship W3208163551A5081402612 @default.
- W3208163551 hasConcept C41008148 @default.
- W3208163551 hasConceptScore W3208163551C41008148 @default.
- W3208163551 hasLocation W32081635511 @default.
- W3208163551 hasOpenAccess W3208163551 @default.
- W3208163551 hasPrimaryLocation W32081635511 @default.
- W3208163551 isParatext "false" @default.
- W3208163551 isRetracted "false" @default.
- W3208163551 magId "3208163551" @default.
- W3208163551 workType "article" @default.