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- W3208170213 abstract "We aimed to determine whether Alemtuzumab-induced immune reconstitution affects immunoglobulin and complement levels in the serum of Relapsing-Remitting Multiple Sclerosis (RRMS) patients. IgG4-levels were increased 24-months after treatment initiation compared to baseline levels in twenty-nine patients. Alemtuzumab-treated patients with the highest IgG4-levels were more prone to thyroid-related autoimmune manifestations and specific autoimmune adverse events such as Crohn's disease, Graves' disease, and hemolytic anemia. Compared to baseline, total IgG-levels showed a trend towards reduced levels following two-courses of Alemtuzumab, but no significant change of C3 and/or C4-levels was observed. In conclusion, monitoring of IgG4-levels can serve as a marker for secondary autoimmunity risk in multiple sclerosis patients treated with Alemtuzumab." @default.
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- W3208170213 date "2021-12-01" @default.
- W3208170213 modified "2023-10-01" @default.
- W3208170213 title "IgG4-related autoimmune manifestations in Alemtuzumab-treated multiple sclerosis patients" @default.
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- W3208170213 doi "https://doi.org/10.1016/j.jneuroim.2021.577759" @default.
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