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• W3208175059 abstract "Platelet-rich fibrin (PRF) has been utilized as a substitute for resorbable membranes during guided bone regeneration therapy as it is a more bioactive biomaterial with living cells and growth factors than resorbable membranes. Nevertheless, PRF poses obvious disadvantages in its mechanical strength since its rapid degradability has been shown to typically resorb within a 2-week time period. In the present study, the barrier function and biological and mechanical properties of PRF were investigated both as standard therapy and after thermal processing. Two heating processes were applied: both single-side heating and double-side heating at 90°C for 10 s using a metal plate heater. The appearance and weight of PRF membranes were documented after heating, along with their morphological and mechanical properties evaluated by scanning electron microscope and tensile strength tests. The viability of cells found within PRF membranes was also evaluated using live/dead cell viability and CCK-8 (cell counting kit-8) assays. To comprehensively evaluate the barrier function of PRF membranes, Hoechst staining of human gingival fibroblasts, which can be distinguished from cells within the PRF membrane by emitting blue light at an excitation wavelength of 488 nm, was seeded onto the surface of PRF membranes. Furthermore, osteoblasts were cultured with extracts from different PRF groups to evaluate the biocompatibility of PRF membranes. The degradation rate of PRF membranes was examined by digestion assay. Compared with the nonheated PRF control, the size and weight of PRF membranes led to a significant decrease with a denser PRF microstructure following heating. In summary, the double-sided heating of PRF membranes not only demonstrated an improvement in mechanical and degradation properties but also led to a decrease in cell viability and proliferation. Platelet-rich fibrin (PRF) is getting more and more attention in the field of guided bone regeneration, especially used as the barrier membrane. However, the rapid degradation property restricts its usage. It has been found that heating, as a nonadditive treatment method, can prolong the degradation time of PRF in vivo and in vitro, but most of the current research on PRF heating treatment is limited to research about the degradation time of PRF membrane. Our work herein systematically and comprehensively evaluated the structure, mechanical properties, barrier function, and bioactivity of the PRF membrane after heating treatment." @default.
• W3208175059 created "2021-11-08" @default.
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• W3208175059 date "2021-11-01" @default.
• W3208175059 modified "2023-09-24" @default.
• W3208175059 title "Structure, Barrier Function, and Bioactivity of Platelet-Rich Fibrin Following Thermal Processing" @default.
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• W3208175059 doi "https://doi.org/10.1089/ten.tec.2021.0177" @default.
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