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- W3208176951 abstract "Objectives: To examine the relation of IL-6 levels in the CSF to the severity ofhypoxic-ischemic encephalopathy (HIE) and to the outcome. Methods: Asphyxiatedterm neonates were included. Cerebrospinal fluid (CSF) IL-6 was measured by asensitive ELISA. Results: 20 neonates were studied: 3 had no HIE, 5 had stage 1, 6 hadstage 2, and 6 had stage 3. CSF IL-6 levels (8 to 90 hours of life) were higher inneonates with mE stage 3 (range 65 to 2250 pg/ml) when compared to neonates withHIE stage o to 2 «2 pg/ml in 12 neonates, lO pg/ml in 1)(P<0.01). 5 neonates hadadverse outcome: 4 died, and 1 had cerebral palsy. 13 had normal outcome. CSF IL-6 levels (10.8±6.1 months) were higher in neonates with adverse outcome (range 65 to2250 pg/rnl) compared to neonates with favorable outcome (P<0.05).Conclusion: IL-6 levels in the CSF are related to neonatal neurological manifestationsand to the outcome. Our results suggest that IL-6 is implicated in the pathogenesis ofneonatal hypoxic-ischemic brain damage." @default.
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- W3208176951 date "1996-12-20" @default.
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- W3208176951 title "Inflarnmatory response in the central nervous systern following perinatal asphyxia" @default.
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