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- W3208180069 abstract "Possible formation of G-quadruplex (G4) structures in telomere and mitochondrial DNA (mtDNA) are the subjects of intense current research interest. The telomere, a complex of repetitive nucleotide sequences and binding proteins, is present at the end of chromosomes to safeguard genomic stability. G4, a noncanonical DNA structure, forms in guanine-rich nucleic acid sequences such as immunoglobulin switch regions, telomeres, promoter regions (especially of oncogenes), and 5′-untranslated regions of genes. G4 motifs have been recognized as regulatory structures and are associated with genome instability and gene expression defects in the nuclear genome. The mitochondrial genome is a circular double-stranded DNA with significant asymmetry in strand composition. Mitochondrial DNA, especially the heavy (H) strand, is rich in guanine sequences and hence shows a strong propensity to form G4 structures that have been associated with mtDNA deletion breakpoints. mtDNA deletions are notably observed in various genetic disorders, mitochondrial dysfunction, cancer, and aging. Telomerase, which maintains telomere length, shuttles dynamically between different cellular locations. Under oxidative stress, telomerase localizes to mitochondria; however, little is known about the role of the interaction between the G4 structures in mtDNA and telomerase in determining mitochondrial function and fate. In this review, we cover the recent evidences supporting the potential of G4 structures and telomerase to regulate mitochondrial function and mitochondrial fate." @default.
- W3208180069 created "2021-11-08" @default.
- W3208180069 creator A5038984650 @default.
- W3208180069 creator A5066080920 @default.
- W3208180069 date "2021-01-01" @default.
- W3208180069 modified "2023-09-24" @default.
- W3208180069 title "Impact of Reactive Oxygen Species and G-Quadruplexes in Telomeres and Mitochondria" @default.
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