FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208183446> ?p ?o ?g. }

• W3208183446 endingPage "1875" @default.
• W3208183446 startingPage "1858" @default.
• W3208183446 abstract "Cell cycle progression requires control of the abundance of several proteins and RNAs over space and time to properly transit from one phase to the next and to ensure faithful genomic inheritance in daughter cells. The proteasome, the main protein degradation system of the cell, facilitates the establishment of a proteome specific to each phase of the cell cycle. Its activity also strongly influences transcription. Here, we detected the upregulation of repetitive RNAs upon proteasome inhibition in human cancer cells using RNA-seq. The effect of proteasome inhibition on centromeres was remarkable, especially on α-Satellite RNAs. We showed that α-Satellite RNAs fluctuate along the cell cycle and interact with members of the cohesin ring, suggesting that these transcripts may take part in the regulation of mitotic progression. Next, we forced exogenous overexpression and used gapmer oligonucleotide targeting to demonstrate that α-Sat RNAs have regulatory roles in mitosis. Finally, we explored the transcriptional regulation of α-Satellite DNA. Through in silico analyses, we detected the presence of CCAAT transcription factor-binding motifs within α-Satellite centromeric arrays. Using high-resolution three-dimensional immuno-FISH and ChIP-qPCR, we showed an association between the α-Satellite upregulation and the recruitment of the transcription factor NFY-A to the centromere upon MG132-induced proteasome inhibition. Together, our results show that the proteasome controls α-Satellite RNAs associated with the regulation of mitosis." @default.
• W3208183446 created "2021-11-08" @default.
• W3208183446 creator A5001440043 @default.
• W3208183446 creator A5004647444 @default.
• W3208183446 creator A5006271450 @default.
• W3208183446 creator A5020982259 @default.
• W3208183446 creator A5024332177 @default.
• W3208183446 creator A5026984171 @default.
• W3208183446 creator A5027722273 @default.
• W3208183446 creator A5041061250 @default.
• W3208183446 creator A5042419272 @default.
• W3208183446 creator A5044153523 @default.
• W3208183446 creator A5044308432 @default.
• W3208183446 creator A5046741732 @default.
• W3208183446 creator A5047535602 @default.
• W3208183446 creator A5055112670 @default.
• W3208183446 creator A5058171940 @default.
• W3208183446 creator A5060564308 @default.
• W3208183446 creator A5072439371 @default.
• W3208183446 creator A5073018357 @default.
• W3208183446 creator A5074721055 @default.
• W3208183446 creator A5079812095 @default.
• W3208183446 creator A5080437142 @default.
• W3208183446 creator A5084541770 @default.
• W3208183446 creator A5084875232 @default.
• W3208183446 creator A5086844448 @default.
• W3208183446 date "2021-11-18" @default.
• W3208183446 modified "2023-10-16" @default.
• W3208183446 title "Proteasome inhibition alters mitotic progression through the upregulation of centromeric α‐Satellite RNAs" @default.
• W3208183446 cites W1949152416 @default.
• W3208183446 cites W1969772407 @default.
• W3208183446 cites W1973638003 @default.
• W3208183446 cites W1983642572 @default.
• W3208183446 cites W1992127633 @default.
• W3208183446 cites W1992788889 @default.
• W3208183446 cites W1998004003 @default.
• W3208183446 cites W1999966058 @default.
• W3208183446 cites W2013237763 @default.
• W3208183446 cites W2014270114 @default.
• W3208183446 cites W2015761297 @default.
• W3208183446 cites W2020714026 @default.
• W3208183446 cites W2035618305 @default.
• W3208183446 cites W2047828925 @default.
• W3208183446 cites W2048938594 @default.
• W3208183446 cites W2051875167 @default.
• W3208183446 cites W2058831580 @default.
• W3208183446 cites W2065629914 @default.
• W3208183446 cites W2079806411 @default.
• W3208183446 cites W2091925442 @default.
• W3208183446 cites W2092697706 @default.
• W3208183446 cites W2096652998 @default.
• W3208183446 cites W2096884102 @default.
• W3208183446 cites W2108575282 @default.
• W3208183446 cites W2127540003 @default.
• W3208183446 cites W2144256548 @default.
• W3208183446 cites W2146341019 @default.
• W3208183446 cites W2147408555 @default.
• W3208183446 cites W2148114118 @default.
• W3208183446 cites W2150304956 @default.
• W3208183446 cites W2151526425 @default.
• W3208183446 cites W2155080972 @default.
• W3208183446 cites W2157083470 @default.
• W3208183446 cites W2167759582 @default.
• W3208183446 cites W2169456326 @default.
• W3208183446 cites W2179438025 @default.
• W3208183446 cites W2196899564 @default.
• W3208183446 cites W2473340875 @default.
• W3208183446 cites W2548949880 @default.
• W3208183446 cites W2586629822 @default.
• W3208183446 cites W2740520136 @default.
• W3208183446 cites W2742299924 @default.
• W3208183446 cites W2770935577 @default.
• W3208183446 cites W2815423913 @default.
• W3208183446 cites W2900569176 @default.
• W3208183446 cites W2952527196 @default.
• W3208183446 cites W2952660586 @default.
• W3208183446 cites W2971941127 @default.
• W3208183446 cites W2994103509 @default.
• W3208183446 cites W3014479432 @default.
• W3208183446 cites W3023617318 @default.
• W3208183446 cites W3090490686 @default.
• W3208183446 cites W3098866200 @default.
• W3208183446 cites W3155510922 @default.
• W3208183446 cites W4237153647 @default.
• W3208183446 cites W4250359879 @default.
• W3208183446 doi "https://doi.org/10.1111/febs.16261" @default.
• W3208183446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34739170" @default.
• W3208183446 hasPublicationYear "2021" @default.
• W3208183446 type Work @default.
• W3208183446 sameAs 3208183446 @default.
• W3208183446 citedByCount "3" @default.
• W3208183446 countsByYear W32081834462022 @default.
• W3208183446 countsByYear W32081834462023 @default.
• W3208183446 crossrefType "journal-article" @default.
• W3208183446 hasAuthorship W3208183446A5001440043 @default.
• W3208183446 hasAuthorship W3208183446A5004647444 @default.
• W3208183446 hasAuthorship W3208183446A5006271450 @default.
• W3208183446 hasAuthorship W3208183446A5020982259 @default.

• next