FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208184477> ?p ?o ?g. }

• W3208184477 abstract "Abstract The present study was deliberately focused to explore the antivirulence efficacy of a plant allelochemical—catechol against Candida albicans , and attempts were made to elucidate the underlying mechanisms as well. Catechol at its sub-MIC concentrations (2–256 μg/mL) exhibited a dose dependent biofilm as well as hyphal inhibitory efficacies, which were ascertained through both light and fluorescence microscopic analyses. Further, sub-MICs of catechol displayed remarkable antivirulence efficacy, as it substantially inhibited C. albicans’ virulence enzymes i.e. secreted hydrolases. Notably, FTIR analysis divulged the potency of catechol in effective loosening of C. albicans ’ exopolymeric matrix, which was further reinforced using EPS quantification assay. Although, catechol at BIC (256 μg/mL) did not disrupt the mature biofilms of C. albicans , their initial adherence was significantly impeded by reducing their hydrophobic nature. Besides, FTIR analysis also unveiled the ability of catechol in enhancing the production of farnesol—a metabolite of C. albicans , whose accumulation naturally blocks yeast-hyphal transition. The qPCR data showed significant down-regulation of candidate genes viz., RAS1, HWP1 and ALS3 which are the key targets of Ras-cAMP-PKA pathway -the pathway that contribute for C. albicans ’ pathogenesis. Interestingly, the up-regulation of TUP1 (a gene responsible for farnesol-mediated hyphal inhibition) during catechol exposure strengthen the speculation of catechol triggered farnesol-mediated hyphal inhibition. Furthermore, catechol profusely enhanced the fungicidal efficacy of certain known antifungal agent’s viz., azoles (ketoconazole and miconazole) and polyenes (amphotericin-B and nystatin)." @default.
• W3208184477 created "2021-11-08" @default.
• W3208184477 creator A5004435215 @default.
• W3208184477 creator A5006850660 @default.
• W3208184477 creator A5018158090 @default.
• W3208184477 creator A5018781281 @default.
• W3208184477 creator A5069559991 @default.
• W3208184477 date "2021-10-26" @default.
• W3208184477 modified "2023-10-16" @default.
• W3208184477 title "Catechol thwarts virulent dimorphism in Candida albicans and potentiates the antifungal efficacy of azoles and polyenes" @default.
• W3208184477 cites W1494395715 @default.
• W3208184477 cites W1982151856 @default.
• W3208184477 cites W1984264528 @default.
• W3208184477 cites W1993800351 @default.
• W3208184477 cites W1999340863 @default.
• W3208184477 cites W2005871124 @default.
• W3208184477 cites W2006952742 @default.
• W3208184477 cites W2027948548 @default.
• W3208184477 cites W2028042667 @default.
• W3208184477 cites W2035332297 @default.
• W3208184477 cites W2047291387 @default.
• W3208184477 cites W2059140883 @default.
• W3208184477 cites W2070620676 @default.
• W3208184477 cites W2071482962 @default.
• W3208184477 cites W2099473578 @default.
• W3208184477 cites W2108244474 @default.
• W3208184477 cites W2125040423 @default.
• W3208184477 cites W2125848302 @default.
• W3208184477 cites W2133183053 @default.
• W3208184477 cites W2136327514 @default.
• W3208184477 cites W2136753636 @default.
• W3208184477 cites W2145661430 @default.
• W3208184477 cites W2145733903 @default.
• W3208184477 cites W2157594666 @default.
• W3208184477 cites W2158528341 @default.
• W3208184477 cites W2165459255 @default.
• W3208184477 cites W2167167348 @default.
• W3208184477 cites W2419164965 @default.
• W3208184477 cites W2508573798 @default.
• W3208184477 cites W2537474574 @default.
• W3208184477 cites W2562472569 @default.
• W3208184477 cites W2607185996 @default.
• W3208184477 cites W2736121634 @default.
• W3208184477 cites W2792847166 @default.
• W3208184477 cites W2806610516 @default.
• W3208184477 cites W2888886372 @default.
• W3208184477 cites W2891298374 @default.
• W3208184477 cites W2902710038 @default.
• W3208184477 cites W2903234151 @default.
• W3208184477 cites W2909240409 @default.
• W3208184477 cites W2916562017 @default.
• W3208184477 cites W2916829388 @default.
• W3208184477 cites W2920509585 @default.
• W3208184477 cites W2969899047 @default.
• W3208184477 cites W2990940638 @default.
• W3208184477 cites W2991263388 @default.
• W3208184477 cites W2997730179 @default.
• W3208184477 cites W3025895416 @default.
• W3208184477 cites W3091959518 @default.
• W3208184477 cites W3093656238 @default.
• W3208184477 cites W3101282355 @default.
• W3208184477 doi "https://doi.org/10.1038/s41598-021-00485-2" @default.
• W3208184477 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8548306" @default.
• W3208184477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34702898" @default.
• W3208184477 hasPublicationYear "2021" @default.
• W3208184477 type Work @default.
• W3208184477 sameAs 3208184477 @default.
• W3208184477 citedByCount "8" @default.
• W3208184477 countsByYear W32081844772022 @default.
• W3208184477 countsByYear W32081844772023 @default.
• W3208184477 crossrefType "journal-article" @default.
• W3208184477 hasAuthorship W3208184477A5004435215 @default.
• W3208184477 hasAuthorship W3208184477A5006850660 @default.
• W3208184477 hasAuthorship W3208184477A5018158090 @default.
• W3208184477 hasAuthorship W3208184477A5018781281 @default.
• W3208184477 hasAuthorship W3208184477A5069559991 @default.
• W3208184477 hasBestOaLocation W32081844771 @default.
• W3208184477 hasConcept C104317684 @default.
• W3208184477 hasConcept C145081991 @default.
• W3208184477 hasConcept C185592680 @default.
• W3208184477 hasConcept C2777229883 @default.
• W3208184477 hasConcept C2777713698 @default.
• W3208184477 hasConcept C2777910421 @default.
• W3208184477 hasConcept C2779247237 @default.
• W3208184477 hasConcept C2779548794 @default.
• W3208184477 hasConcept C2780917455 @default.
• W3208184477 hasConcept C2781064554 @default.
• W3208184477 hasConcept C523546767 @default.
• W3208184477 hasConcept C54355233 @default.
• W3208184477 hasConcept C55493867 @default.
• W3208184477 hasConcept C58123911 @default.
• W3208184477 hasConcept C60987743 @default.
• W3208184477 hasConcept C86803240 @default.
• W3208184477 hasConcept C89423630 @default.
• W3208184477 hasConcept C90080823 @default.
• W3208184477 hasConcept C98274493 @default.
• W3208184477 hasConceptScore W3208184477C104317684 @default.
• W3208184477 hasConceptScore W3208184477C145081991 @default.
• W3208184477 hasConceptScore W3208184477C185592680 @default.
• W3208184477 hasConceptScore W3208184477C2777229883 @default.

• next