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• W3208197345 endingPage "109943" @default.
• W3208197345 startingPage "109943" @default.
• W3208197345 abstract "The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at thousands of loci where ARID1A acts to generate accessible minidomains of nucleosomes. Loss of ARID1A also results in the redistribution of the coactivator EP300. Co-incident EP300 dissociation and lost chromatin accessibility at enhancer elements are highly enriched adjacent to rapidly downregulated genes. In contrast, sites of gained EP300 occupancy are linked to genes that are transcriptionally upregulated. These chromatin changes are associated with a small number of genes that are differentially expressed in the first hours following loss of ARID1A. Indirect or adaptive changes dominate the transcriptome following growth for days after loss of ARID1A and result in strong engagement with cancer pathways. The identification of this hierarchy suggests sites for intervention in ARID1A-driven diseases." @default.
• W3208197345 created "2021-11-08" @default.
• W3208197345 creator A5007965740 @default.
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• W3208197345 creator A5089929533 @default.
• W3208197345 date "2021-11-01" @default.
• W3208197345 modified "2023-10-16" @default.
• W3208197345 title "Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription" @default.
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