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- W3208199893 abstract "Li-Fraumeni syndrome (LFS) is an inherited autosomal-dominant tumor-predisposition disorder caused by germline mutations in the TP53 tumor suppressor gene. Since patients with LFS are likely to develop therapy-related cancers, radiation therapy should be avoided if breast cancer is found in these individuals. Herein, we present a case of secondary breast cancer in an LFS patient after radiation and chemotherapy for the first diagnosed breast sarcoma.Li-Fraumeni 증후군(이하 LFS)은 TP53 종양 억제 유전자의 생식세포 돌연변이로 인한 상염색체 우성 종양 유발 유전 질환이다. LFS 환자에서는 치료 후 치료와 관련된 암이 발생하기 때문에 LFS 환자에서 발생한 유방암의 치료에 있어 방사선 요법을 피해야 한다. 저자들은 LFS 환자에서 발생한 유방 육종의 방사선 및 화학 요법 치료 후 발생한 유방암 증례를 보고한다." @default.
- W3208199893 created "2021-11-08" @default.
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- W3208199893 date "2021-01-01" @default.
- W3208199893 modified "2023-09-23" @default.
- W3208199893 title "Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report" @default.
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- W3208199893 doi "https://doi.org/10.3348/jksr.2021.0045" @default.
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