FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208210631> ?p ?o ?g. }

• W3208210631 endingPage "1544" @default.
• W3208210631 startingPage "1544" @default.
• W3208210631 abstract "In clinical studies, OM-85 Broncho-Vaxom®, a bacterial lysate, reduced viral respiratory tract infection. Infection of epithelial cells by SARS-CoV-2 depends on the interaction of its spike-protein (S-protein) with host cell membrane proteins. In this study, we investigated the effect of OM-85 on the expression of S-protein binding proteins by human bronchial epithelial cells. Human bronchial epithelial cells were treated with OM-85 over 5 days. The expression of SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2), transmembrane protease serine subtype 2 (TMPRSS2), dipeptidyl peptidase-4 (DPP4), and a disintegrin and metalloprotease 17 (ADAM17) were determined by Western blotting and quantitative RT-PCR. Soluble (s)ACE2, heparan sulfate, heparanase, and hyaluronic acid were assessed by ELISA. OM-85 significantly reduced the expression of ACE2 (p < 0.001), TMPRSS2 (p < 0.001), DPP4 (p < 0.005), and cellular heparan sulfate (p < 0.01), while ADAM17 (p < 0.02) expression was significantly upregulated. Furthermore, OM-85 increased the level of sACE2 (p < 0.05), hyaluronic acid (p < 0.002), and hyaluronan synthase 1 (p < 0.01). Consequently, the infection by a SARS-CoV-2 spike protein pseudo-typed lentivirus was reduced in cells pretreated with OM-85. All effects of OM-85 were concentration- and time-dependent. The results suggest that OM-85 might reduce the binding of SARS-CoV-2 S-protein to epithelial cells by modification of host cell membrane proteins and specific glycosaminoglycans. Thus, OM-85 might be considered as an add-on for COVID-19 therapy." @default.
• W3208210631 created "2021-11-08" @default.
• W3208210631 creator A5002684303 @default.
• W3208210631 creator A5054276372 @default.
• W3208210631 creator A5067952145 @default.
• W3208210631 creator A5077426550 @default.
• W3208210631 date "2021-10-26" @default.
• W3208210631 modified "2023-09-27" @default.
• W3208210631 title "OM-85 Broncho-Vaxom®, a Bacterial Lysate, Reduces SARS-CoV-2 Binding Proteins on Human Bronchial Epithelial Cells" @default.
• W3208210631 cites W1999951077 @default.
• W3208210631 cites W2058726633 @default.
• W3208210631 cites W2112240261 @default.
• W3208210631 cites W2112296939 @default.
• W3208210631 cites W2132117442 @default.
• W3208210631 cites W2167448878 @default.
• W3208210631 cites W2344044712 @default.
• W3208210631 cites W2593445491 @default.
• W3208210631 cites W2768273473 @default.
• W3208210631 cites W2777208479 @default.
• W3208210631 cites W2896531727 @default.
• W3208210631 cites W2933811619 @default.
• W3208210631 cites W2948194616 @default.
• W3208210631 cites W2969913502 @default.
• W3208210631 cites W2977713107 @default.
• W3208210631 cites W2995645100 @default.
• W3208210631 cites W3017302293 @default.
• W3208210631 cites W3021640348 @default.
• W3208210631 cites W3032838347 @default.
• W3208210631 cites W3033154423 @default.
• W3208210631 cites W3033171357 @default.
• W3208210631 cites W3035584582 @default.
• W3208210631 cites W3036071663 @default.
• W3208210631 cites W3038622946 @default.
• W3208210631 cites W3039275618 @default.
• W3208210631 cites W3043821401 @default.
• W3208210631 cites W3061118318 @default.
• W3208210631 cites W3085008014 @default.
• W3208210631 cites W3085153423 @default.
• W3208210631 cites W3088544507 @default.
• W3208210631 cites W3089043805 @default.
• W3208210631 cites W3091962185 @default.
• W3208210631 cites W3093015530 @default.
• W3208210631 cites W3093322093 @default.
• W3208210631 cites W3100680010 @default.
• W3208210631 cites W3103061896 @default.
• W3208210631 cites W3103391088 @default.
• W3208210631 cites W3108943871 @default.
• W3208210631 cites W3112077444 @default.
• W3208210631 cites W3113967221 @default.
• W3208210631 cites W3114254168 @default.
• W3208210631 cites W3115315281 @default.
• W3208210631 cites W3118262634 @default.
• W3208210631 cites W3119344443 @default.
• W3208210631 cites W3121446408 @default.
• W3208210631 cites W3123948979 @default.
• W3208210631 cites W3126611040 @default.
• W3208210631 cites W3127354083 @default.
• W3208210631 cites W3129117243 @default.
• W3208210631 cites W3132628130 @default.
• W3208210631 cites W3133289491 @default.
• W3208210631 cites W3134107866 @default.
• W3208210631 cites W3138487919 @default.
• W3208210631 cites W3155582290 @default.
• W3208210631 cites W3158210316 @default.
• W3208210631 cites W3165497143 @default.
• W3208210631 cites W3174037491 @default.
• W3208210631 cites W3175451939 @default.
• W3208210631 cites W3176412535 @default.
• W3208210631 cites W4241350782 @default.
• W3208210631 doi "https://doi.org/10.3390/biomedicines9111544" @default.
• W3208210631 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8615539" @default.
• W3208210631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34829773" @default.
• W3208210631 hasPublicationYear "2021" @default.
• W3208210631 type Work @default.
• W3208210631 sameAs 3208210631 @default.
• W3208210631 citedByCount "11" @default.
• W3208210631 countsByYear W32082106312022 @default.
• W3208210631 countsByYear W32082106312023 @default.
• W3208210631 crossrefType "journal-article" @default.
• W3208210631 hasAuthorship W3208210631A5002684303 @default.
• W3208210631 hasAuthorship W3208210631A5054276372 @default.
• W3208210631 hasAuthorship W3208210631A5067952145 @default.
• W3208210631 hasAuthorship W3208210631A5077426550 @default.
• W3208210631 hasBestOaLocation W32082106311 @default.
• W3208210631 hasConcept C153074725 @default.
• W3208210631 hasConcept C153911025 @default.
• W3208210631 hasConcept C181199279 @default.
• W3208210631 hasConcept C185592680 @default.
• W3208210631 hasConcept C2778041096 @default.
• W3208210631 hasConcept C55493867 @default.
• W3208210631 hasConcept C55728118 @default.
• W3208210631 hasConcept C86803240 @default.
• W3208210631 hasConceptScore W3208210631C153074725 @default.
• W3208210631 hasConceptScore W3208210631C153911025 @default.
• W3208210631 hasConceptScore W3208210631C181199279 @default.
• W3208210631 hasConceptScore W3208210631C185592680 @default.
• W3208210631 hasConceptScore W3208210631C2778041096 @default.
• W3208210631 hasConceptScore W3208210631C55493867 @default.

• next