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- W3208211160 abstract "A key regulator of collective cell migrations, which drive development and cancer metastasis, is substrate stiffness. Increased substrate stiffness promotes migration and is controlled by Myosin. Using Drosophila border cell migration as a model of collective cell migration, we identify, for the first time, that the actin bundling protein Fascin limits Myosin activity in vivo. Loss of Fascin results in: increased activated Myosin on the border cells and their substrate, the nurse cells; decreased border cell Myosin dynamics; and increased nurse cell stiffness as measured by atomic force microscopy. Reducing Myosin restores on-time border cell migration in fascin mutant follicles. Further, Fascin’s actin bundling activity is required to limit Myosin activation. Surprisingly, we find that Fascin regulates Myosin activity in the border cells to control nurse cell stiffness to promote migration. Thus, these data shift the paradigm from a substrate stiffness-centric model of regulating migration, to uncover that collectively migrating cells play a critical role in controlling the mechanical properties of their substrate in order to promote their own migration. This understudied means of mechanical regulation of migration is likely conserved across contexts and organisms, as Fascin and Myosin are common regulators of cell migration." @default.
- W3208211160 created "2021-11-08" @default.
- W3208211160 creator A5017028389 @default.
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- W3208211160 date "2021-10-26" @default.
- W3208211160 modified "2023-10-16" @default.
- W3208211160 title "Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration" @default.
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- W3208211160 doi "https://doi.org/10.7554/elife.69836" @default.
- W3208211160 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8547955" @default.