Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208211580> ?p ?o ?g. }
- W3208211580 abstract "Abstract This study aimed to investigate the anticancer activity of dried-pericarp water extract of fermented C. japonicus (CJ). The dried-pericarp water extracts of CJ were fermented using Aspergillus oryzae and Saccharomyces cerevisiae at 30 °C and 35 °C. The anticancer activities of both water extracts fermented at 30 °C and 35 °C using A. oryzae against FaDu cells were remarkably changed compared with unfermented dried-pericarp water extract of CJ, which has no anticancer activity. Cleaved-PARP, caspase 3, and apoptotic cells stained with annexin V/PI were significantly increased by treatment with A. oryzae extracts fermented at 30 °C. The insulin-like growth factor-binding protein 2 (IGFBP-2) protein level and mTOR phosphorylation by A. oryzae fermented extracts (AOFE) were dramatically reduced, and the expression levels of IGFBP-2 and phosphorylated mTOR were significantly increased depending on the glucose concentrations in FaDu cells. These results suggested that the cell viabilities in AOFE were restored as the glucose concentrations increased. Furthermore, it was confirmed LC/MS/MS that the content of gallic acid was increased by fermentation of Aspergillus oryzae (5.596 ± 0.1746 μg/mg) compared to the unfermented extract (1.620 ± 0.0432 μg/mg). Based on these results, the anticancer effect of AOFE was achieved through inhibition of the IGFBP-2/mTOR signaling pathway. These results suggest that AOFE may be a potential treatment for head and neck cancer." @default.
- W3208211580 created "2021-11-08" @default.
- W3208211580 creator A5029176930 @default.
- W3208211580 creator A5038890216 @default.
- W3208211580 creator A5067339652 @default.
- W3208211580 creator A5088356091 @default.
- W3208211580 date "2021-11-02" @default.
- W3208211580 modified "2023-09-27" @default.
- W3208211580 title "Anticancer properties of dried-pericarp water extracts of Camellia japonica L. fermented with Aspergillus oryzae through regulation of IGFBP-2/mTOR pathway" @default.
- W3208211580 cites W100082921 @default.
- W3208211580 cites W1491177143 @default.
- W3208211580 cites W1607110680 @default.
- W3208211580 cites W1854592836 @default.
- W3208211580 cites W1903875142 @default.
- W3208211580 cites W1973470588 @default.
- W3208211580 cites W1973839771 @default.
- W3208211580 cites W1979861676 @default.
- W3208211580 cites W1981494298 @default.
- W3208211580 cites W1994998895 @default.
- W3208211580 cites W1995398299 @default.
- W3208211580 cites W1998025500 @default.
- W3208211580 cites W2000622771 @default.
- W3208211580 cites W2005645684 @default.
- W3208211580 cites W2006483529 @default.
- W3208211580 cites W2016996307 @default.
- W3208211580 cites W2019629273 @default.
- W3208211580 cites W2023131696 @default.
- W3208211580 cites W2026816311 @default.
- W3208211580 cites W2028704753 @default.
- W3208211580 cites W2033346155 @default.
- W3208211580 cites W2036382349 @default.
- W3208211580 cites W2037976507 @default.
- W3208211580 cites W2039506610 @default.
- W3208211580 cites W2042619042 @default.
- W3208211580 cites W2043470971 @default.
- W3208211580 cites W2058010905 @default.
- W3208211580 cites W2068434821 @default.
- W3208211580 cites W2103279761 @default.
- W3208211580 cites W2109054428 @default.
- W3208211580 cites W2110946818 @default.
- W3208211580 cites W2112873044 @default.
- W3208211580 cites W2129793908 @default.
- W3208211580 cites W2142125753 @default.
- W3208211580 cites W2167741612 @default.
- W3208211580 cites W2233660557 @default.
- W3208211580 cites W2299652449 @default.
- W3208211580 cites W2568962962 @default.
- W3208211580 cites W2740881335 @default.
- W3208211580 cites W2761843869 @default.
- W3208211580 cites W2801965936 @default.
- W3208211580 cites W2889684687 @default.
- W3208211580 cites W2892425221 @default.
- W3208211580 cites W2901208925 @default.
- W3208211580 cites W2943343942 @default.
- W3208211580 cites W2944533801 @default.
- W3208211580 cites W2948516831 @default.
- W3208211580 cites W2950277538 @default.
- W3208211580 cites W2965731048 @default.
- W3208211580 cites W3013322249 @default.
- W3208211580 cites W3026053802 @default.
- W3208211580 doi "https://doi.org/10.1038/s41598-021-01127-3" @default.
- W3208211580 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8564518" @default.
- W3208211580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34728751" @default.
- W3208211580 hasPublicationYear "2021" @default.
- W3208211580 type Work @default.
- W3208211580 sameAs 3208211580 @default.
- W3208211580 citedByCount "2" @default.
- W3208211580 countsByYear W32082115802022 @default.
- W3208211580 countsByYear W32082115802023 @default.
- W3208211580 crossrefType "journal-article" @default.
- W3208211580 hasAuthorship W3208211580A5029176930 @default.
- W3208211580 hasAuthorship W3208211580A5038890216 @default.
- W3208211580 hasAuthorship W3208211580A5067339652 @default.
- W3208211580 hasAuthorship W3208211580A5088356091 @default.
- W3208211580 hasBestOaLocation W32082115801 @default.
- W3208211580 hasConcept C100544194 @default.
- W3208211580 hasConcept C185592680 @default.
- W3208211580 hasConcept C190283241 @default.
- W3208211580 hasConcept C2781204770 @default.
- W3208211580 hasConcept C31903555 @default.
- W3208211580 hasConcept C55493867 @default.
- W3208211580 hasConcept C86554907 @default.
- W3208211580 hasConceptScore W3208211580C100544194 @default.
- W3208211580 hasConceptScore W3208211580C185592680 @default.
- W3208211580 hasConceptScore W3208211580C190283241 @default.
- W3208211580 hasConceptScore W3208211580C2781204770 @default.
- W3208211580 hasConceptScore W3208211580C31903555 @default.
- W3208211580 hasConceptScore W3208211580C55493867 @default.
- W3208211580 hasConceptScore W3208211580C86554907 @default.
- W3208211580 hasFunder F4320334881 @default.
- W3208211580 hasIssue "1" @default.
- W3208211580 hasLocation W32082115801 @default.
- W3208211580 hasLocation W32082115802 @default.
- W3208211580 hasLocation W32082115803 @default.
- W3208211580 hasLocation W32082115804 @default.
- W3208211580 hasLocation W32082115805 @default.
- W3208211580 hasOpenAccess W3208211580 @default.
- W3208211580 hasPrimaryLocation W32082115801 @default.
- W3208211580 hasRelatedWork W1585643465 @default.
- W3208211580 hasRelatedWork W2029547399 @default.