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- W3208229086 abstract "Biomarkers play a key role in the comprehensive pathologic evaluation of gastrointestinal malignancies. These biomarkers can be predictive, indicating whether a tumor is likely to respond to a particular therapy, or prognostic, providing information about the likely course and outcome of a disease. This review article will discuss available immunohistochemical stains for assessing these markers, including staining rationale, scoring criteria, associated systemic therapies, and pictorial examples. PD-L1, HER2, and mismatch repair status can be evaluated via immunohistochemistry for esophageal, gastric, and colorectal carcinomas. Biomarkers currently play a more limited role in evaluation of pancreatic and small bowel malignancies. Immunohistochemistry can also be used to evaluate biomarker status in gastrointestinal stromal tumors, gastrointestinal malignancies with NTRK gene fusions, and undifferentiated carcinomas with switch-sucrose non-fermentable complex abnormalities." @default.
- W3208229086 created "2021-11-08" @default.
- W3208229086 creator A5007775477 @default.
- W3208229086 creator A5056194192 @default.
- W3208229086 date "2022-01-01" @default.
- W3208229086 modified "2023-10-17" @default.
- W3208229086 title "Immunohistochemistry as predictive and prognostic markers for gastrointestinal malignancies" @default.
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- W3208229086 doi "https://doi.org/10.1053/j.semdp.2021.10.003" @default.
- W3208229086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34740486" @default.
- W3208229086 hasPublicationYear "2022" @default.
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