FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208233670> ?p ?o ?g. }

• W3208233670 abstract "Obesity is a major health concern that has reached epidemic proportions globally.Malaysia has the highest obesity rate at 14% in the Southeast Asia region. The costand side effects of synthetic anti-obesity drugs necessitate the finding of suitableherbal alternatives. The current study investigated the antiobesity effects ofClinacanthus nutanus crude leaf extract in 80 % methanol (MECN). The sub-acuteoral toxicity of MECN was evaluated in 6-week- old ICR mice (21 males, 21 females).The mice were randomly divided into six treatment groups of seven animals each,comprising of untreated control, mice treated with 1000 and 2000 mg/kg MECN, formales and females. Animals were gavaged with the treatment agents once daily for 28days. Despite the incidental lesions noted for the livers and kidneys, there nodifference (P>0.05) between the histolopathological changes seen among mice treatedwith MECN, and that of the untreated controls in both sexes. No significant changeswere also noted for the physical, hematological and serum biochemical parametersbetween the control and treatment groups for both sexes. However, the serum sodiumlevel in mice treated with 2000 mg/kg MECN was lower than the controls (P<0.05).In the ensuing experiment, MECN was used at 2000 mg/kg as a potential anti-obesityagent in obese mice. Fifty (4-weeks-old) male mice were randomly assigned into 2groups: (1) a normal diet group (NC, n=10); and (2) treatment group (fed a high-fatdiet for 16 weeks, n=40). At 20 weeks of age, the mice fed high-fat diet were randomlyassigned into 4 sub-groups comprising of, high-fat diet only (HFDC); MECN at 500mg/kg (HFD+CN500); 1000 mg/kg (HFD+CN1000) and 1500 mg/kg(HFD+CN1500). All mice were then subjected to 21 days of treatment. The currentstudy showed that MECN treatment at 1000 and 1500 mg/kg reduced body weight,relative visceral fat, serum lipid profile, malondialdehyde (MDA) levels in muscle,cholesterol and saturated fatty acid composition (P<0.05). Visceral fat among MECNtreatedmice showed significant decrease (P<0.05) in hypertrophic adipocyte cell sizecompared to the HFDC group after treatment. The PPARγ and SCD1 genes expression were down-regulated, especially in mice fed with 1000 and 1500 mg/kg of MECNcompared to the HFDC group. Mice treated with MECN at 1500 mg/kg showed adecreased PPARα expression, and an increased expression of HSL mRNA. In termsof adipocytokines, mice treated with MECN at 1000 and 1500 mg/kg showed asignificantly (P<0.05) elevated level of adiponectin, and reduced levels (P<0.05) ofleptin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNFα) compared to theHFDC. In summary, the results suggested that MECN could ameliorate diet-inducedobesity via the regulation of gene expressions and adipocytokines involved in lipidmetabolism. However, future clinical trials are necessary to ascertain its clinicalefficacy." @default.
• W3208233670 created "2021-11-08" @default.
• W3208233670 creator A5032761300 @default.
• W3208233670 date "2019-09-01" @default.
• W3208233670 modified "2023-09-23" @default.
• W3208233670 title "Effects of crude methanolic leaf extract of Clinacanthus nutans (Burm.f.) lindau on high-fat diet-induced obese mice" @default.
• W3208233670 hasPublicationYear "2019" @default.
• W3208233670 type Work @default.
• W3208233670 sameAs 3208233670 @default.
• W3208233670 citedByCount "0" @default.
• W3208233670 crossrefType "dissertation" @default.
• W3208233670 hasAuthorship W3208233670A5032761300 @default.
• W3208233670 hasConcept C126322002 @default.
• W3208233670 hasConcept C140793950 @default.
• W3208233670 hasConcept C29730261 @default.
• W3208233670 hasConcept C511355011 @default.
• W3208233670 hasConcept C556039675 @default.
• W3208233670 hasConcept C71924100 @default.
• W3208233670 hasConcept C86803240 @default.
• W3208233670 hasConceptScore W3208233670C126322002 @default.
• W3208233670 hasConceptScore W3208233670C140793950 @default.
• W3208233670 hasConceptScore W3208233670C29730261 @default.
• W3208233670 hasConceptScore W3208233670C511355011 @default.
• W3208233670 hasConceptScore W3208233670C556039675 @default.
• W3208233670 hasConceptScore W3208233670C71924100 @default.
• W3208233670 hasConceptScore W3208233670C86803240 @default.
• W3208233670 hasLocation W32082336701 @default.
• W3208233670 hasOpenAccess W3208233670 @default.
• W3208233670 hasPrimaryLocation W32082336701 @default.
• W3208233670 hasRelatedWork W1566656514 @default.
• W3208233670 hasRelatedWork W2004514254 @default.
• W3208233670 hasRelatedWork W2118625693 @default.
• W3208233670 hasRelatedWork W2171797203 @default.
• W3208233670 hasRelatedWork W2185977993 @default.
• W3208233670 hasRelatedWork W2188633662 @default.
• W3208233670 hasRelatedWork W2357537792 @default.
• W3208233670 hasRelatedWork W2511327090 @default.
• W3208233670 hasRelatedWork W2555084200 @default.
• W3208233670 hasRelatedWork W2566288994 @default.
• W3208233670 hasRelatedWork W2619889543 @default.
• W3208233670 hasRelatedWork W2786773627 @default.
• W3208233670 hasRelatedWork W2811109366 @default.
• W3208233670 hasRelatedWork W2911431753 @default.
• W3208233670 hasRelatedWork W2913604659 @default.
• W3208233670 hasRelatedWork W2942157806 @default.
• W3208233670 hasRelatedWork W3010989011 @default.
• W3208233670 hasRelatedWork W3143441781 @default.
• W3208233670 hasRelatedWork W2183407095 @default.
• W3208233670 hasRelatedWork W2184029981 @default.
• W3208233670 isParatext "false" @default.
• W3208233670 isRetracted "false" @default.
• W3208233670 magId "3208233670" @default.
• W3208233670 workType "dissertation" @default.